IndraLab

Statements

DNMT1 methylates CDKN2A. 10 / 10
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"In consistent with this hypothesis, we found that P16 methylation by P16-Dnmt directly increased the paclitaxel IC50 value of BGC823 cells, whereas reactivation of P16 demethylation by P16-TET directly decreased the IC50 in H1299 cells."
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"DNMT1 has been shown to be specifically over-expressed in NSCLC lung tumours compared to normal cells where DNMT1 over-expression resulted in increased methylation of the TSGs, FHIT, p16 INK4a and RARbeta 21."
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"DNMT1 siRNA induces demethylation of the tumor suppressor genes SOCS1 and p16."
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"Notably, P16 -specific methylation by P16-Dnmt directly increased the sensitivity of lung cancer cells to palbociclib in vitro and in vivo ."
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"Uropathogenic E. coli infection induces de novo methyltransferase activity and DNMT1 expression causing increased methylation of CDKN2A exon 1 and downregulation of this tumor suppressor gene in uroepithelial cells, which may increase the risk of bladder cancer."
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"In a multivariate analysis, CIMP and MLH1 and CIMP and p16 INK4a methylation statuses were predictive of prognosis, and the OS was longer for patients with tumors CIMP- and MLH1-M, as well as CIMP- and p16 INK4a -M. Furthermore, DNMT1 is significantly overexpressed in tumors than in normal tissues as well as in CIMP+ than CIMP- tumors."
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"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
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"Regulation of DNMT1 and DNMT3A by HBx promoted hypermethylation of p16 (INK4A) promoter region."
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"Based on multiple gene expression analysis (MGEA) using type 1, type 2, and pancreatic intraductal papillary mucinous neoplasms (n=4, 6, and 5, respectively), immunohistochemistry of DNMT1 and methylation-specific PCR for p16, APC, BRCA1, hMLH1, TIMP3, and SOX17 were performed on type 1 and 2 IPNBs (n=14, each)."
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"In contrast, P16 -specific methylation by P16-Dnmt significantly increased paclitaxel resistance of lung cancer HCC827 cells and gastric cancer BGC823 cells (IC50 values increased from 18.2 to 24.0 ng/ml and 0.18 to 0.81 µg/ml, respectively; P =0.049 and <0.001, respectively)."
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