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Modified DNMT3B leads to the methylation of CDKN2A. 2 / 2
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"These results may support our present data showing that a high prevalence of p16INK4a promoter hypermethylation in lung tumors with HPV infection was more favorably associated with DNMT3b than with DN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This indicates that the hypermethylation of the P16INK4A promoter caused by DNMT3b expression strongly demonstrated the cancerization mechanism for female non smokers diagnosed with lung cancer and infected with HPV.65 Genome instabilityScholars have investigated fragile histidine triad protein (FHIT) located on chromosome 3p14.2 to understand the correlation between genome instability and HPV."
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