IndraLab

Statements

TRAP leads to the methylation of CDKN2A. 3 / 3
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"These findings suggest that rapid TRAP exposure may not be sufficient to increase p16 CDKN2A gene promoter methylation, which could be associated with the powerful clearance ability of the respiratory system."
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"In contrast, prolonged TRAP exposure could effectively induce p16 CDKN2A gene hypermethylation, thus reduce p16 CDKN2A gene expression, affect cell cycle, and finally play an important role in the development of multiple pulmonary diseases."
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"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
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