IndraLab

Statements


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reach
"This cooperation involves recruitment of PRC2, which trimethylates H3K27 at the E-cadherin and CDKN2A gene promoters 67."

reach
"These observations suggest that, in the absence of JDP2, H3K27 is methylated by PRC2, and the p16 Ink4a / Arf locus is silenced by PRC1, whereas the increased expression of JDP2 helps to release PRC1 and PRC2 from the p16 Ink4a / Arf locus, thereby reducing H3K27 methylation."