IndraLab

Statements

USP36 is modified
68 | 5
USP36 is phosphorylated.
68 |
USP36 is phosphorylated on S742. 8 / 8
8 |
hprd
No evidence text available
19691289
hprd
No evidence text available
16565220
hprd
No evidence text available
19664995
hprd
No evidence text available
18691976
hprd
No evidence text available
20068231
hprd
No evidence text available
17924679
hprd
No evidence text available
19007248
hprd
No evidence text available
19651622
USP36 is phosphorylated on S464. 6 / 6
6 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19007248
hprd
No evidence text available
19664995
hprd
No evidence text available
18669648
hprd
No evidence text available
19691289
hprd
No evidence text available
19413330
USP36 is phosphorylated on S682. 5 / 5
5 |
hprd
No evidence text available
19413330
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
18669648
hprd
No evidence text available
19664995
USP36 is phosphorylated on S667. 4 / 4
4 |
hprd
No evidence text available
19691289
hprd
No evidence text available
19007248
hprd
No evidence text available
20068231
hprd
No evidence text available
18669648
USP36 is phosphorylated on T680. 4 / 4
4 |
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
hprd
No evidence text available
19664995
hprd
No evidence text available
19413330
USP36 is phosphorylated on T581. 3 / 3
3 |
hprd
No evidence text available
19691289
hprd
No evidence text available
17081983
hprd
No evidence text available
20068231
USP36 is phosphorylated on S952. 3 / 3
3 |
hprd
No evidence text available
17081983
hprd
No evidence text available
20068231
hprd
No evidence text available
19664995
USP36 is phosphorylated on S580. 3 / 3
3 |
hprd
No evidence text available
19691289
hprd
No evidence text available
18691976
hprd
No evidence text available
20068231
USP36 is phosphorylated on S582. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
18669648
USP36 is phosphorylated on S713. 3 / 3
3 |
hprd
No evidence text available
19691289
hprd
No evidence text available
20068231
hprd
No evidence text available
19007248
USP36 is phosphorylated on S679. 2 / 2
2 |
hprd
No evidence text available
19664995
hprd
No evidence text available
18669648
USP36 is phosphorylated on S513. 2 / 2
2 |
hprd
No evidence text available
19691289
hprd
No evidence text available
19413330
USP36 is phosphorylated on S515. 2 / 2
2 |
hprd
No evidence text available
19691289
hprd
No evidence text available
19413330
USP36 is phosphorylated on S871. 1 / 1
1 |
hprd
No evidence text available
19691289
USP36 is phosphorylated on Y1121. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S1050. 1 / 1
1 |
hprd
No evidence text available
19007248
USP36 is phosphorylated on T675. 1 / 1
1 |
hprd
No evidence text available
18669648
USP36 is phosphorylated on S692. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S494. 1 / 1
1 |
hprd
No evidence text available
19007248
USP36 is phosphorylated on S1053. 1 / 1
1 |
hprd
No evidence text available
18077418
USP36 is phosphorylated on S546. 1 / 1
1 |
hprd
No evidence text available
18669648
USP36 is phosphorylated on T653. 1 / 1
1 |
hprd
No evidence text available
19413330
USP36 is phosphorylated on T325. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S614. 1 / 1
1 |
hprd
No evidence text available
19413330
USP36 is phosphorylated on T673. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S612. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S321. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on T467. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S1120. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on Y874. 1 / 1
1 |
hprd
No evidence text available
17081983
USP36 is phosphorylated on S429. 1 / 1
1 |
hprd
No evidence text available
19691289
USP36 is phosphorylated on S671. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is phosphorylated on S613. 1 / 1
1 |
hprd
No evidence text available
19413330
USP36 is ubiquitinated.
| 5
USP36 is ubiquitinated. 5 / 5
| 5
sparser
"Studies have confirmed the ubiquitylation of USP7 [ xref ], USP36 [ xref ], DUB-1 [ xref ] and DUB-1A [ xref ], but limited data are available regarding the significance of these modifications."
28659380
sparser
"Ubiquitination of USP7 (K869), USP24 (K421, K656) and USP36 (K338) were down-regulated."
33865438
sparser
"We first studied how USP36 ubiquitination is regulated upon replication stress, and found decreased USP36 polyubiquitination following HU treatment (Figure xref )."
33237263
sparser
"USP7 ( xref ), USP36 ( xref ) and DUB-1 ( xref , xref ) are also ubiquitinated, although the importance of these modifications is unknown."
19489724
sparser
"In order to confirm the ubiquitination of USP36, co-immunoprecipitation was also performed with an anti-HA antibody (Roche Applied Science, Mannheim, Germany) and Western blot analysis was performed w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15809067
USP36 affects MYC
4 1 | 1 7 1
USP36 binds MYC.
4 | 1 1
USP36 binds MYC. 6 / 6
4 | 1 1
reach
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
sparser
"We further show that USP36 itself is a c-Myc target gene, suggesting that USP36 and c-Myc form a positive feedback regulatory loop."
25775507
USP36 deubiquitinates MYC.
1 | 1 3
USP36 deubiquitinates MYC. 5 / 5
1 | 1 3
reach
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
reach
"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
29263902
reach
"45 USP36 deubiquitinates and stabilizes c-Myc through interactions with FBW7gamma in the nucleolus."
29527331
trips
"The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc."
25775507
ubibrowser
"Review"
27919796
USP36 activates MYC.
| 1
USP36 activates MYC. 1 / 2
| 1
reach
"XREF_BIBR - XREF_BIBR Moreover, the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc."
32140262
USP36 inhibits MYC.
| 1
USP36 inhibits MYC. 1 / 1
| 1
reach
"Thereafter, qRT‐PCR assays were performed on FBXW7, SKP2, USP28, and USP36, which confirmed that Dem could interact with FBXW7 and downregulate the expression of c‐Myc."
34766156
USP36 increases the amount of MYC.
| 1
USP36 increases the amount of MYC. 1 / 1
| 1
reach
"Consistently, knockdown of USP36 reduces the levels of c-Myc and suppresses cell proliferation."
25775507
USP36 affects MYCN
| 7 5
USP36 binds MYCN.
| 5 5
USP36 binds MYCN. 10 / 10
| 5 5
reach
"We found that endogenous MYCN interacts with USP36 in both of the cells lines (XREF_FIG, left and middle panels)."
34056606
sparser
"We found that endogenous MYCN interacts with USP36 in both of the cells lines ( xref , left and middle panels)."
34056606
sparser
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE(2) and IMR-32 cell lines."
34056606
sparser
"Considering that the ubiquitin-specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
reach
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 (XREF_FIG, right panel)."
34056606
reach
"These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN."
34056606
sparser
"USP36 Interacts With MYCN and Regulates Its Stability by Deubiquitination."
34056606
sparser
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 ( xref , right panel)."
34056606
reach
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE (2) and IMR-32 cell lines."
34056606
reach
"Considering that the ubiquitin specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
USP36 increases the amount of MYCN.
| 1
USP36 increases the amount of MYCN. 1 / 1
| 1
reach
"These results strongly suggest that USP36 positively regulates MYCN protein levels."
34056606
USP36 deubiquitinates MYCN.
| 1
USP36 deubiquitinates MYCN. 1 / 1
| 1
reach
"These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN."
34056606
USP36 affects PRIMPOL
| 11
USP36 binds PRIMPOL. 10 / 11
| 11
sparser
"USP36 interacts with PrimPol via its USP domain."
33237263
sparser
"Next, we studied how HU treatment promoted the interaction between USP36 and PrimPol."
33237263
sparser
"On the other hand, in cancer cells, higher expression of USP36 might render cancer cells resistant to replication stress, while lower USP36 level or inhibition of USP36-PrimPol axis might sensitize cancer cells to genotoxic insults."
33237263
sparser
"Overall, these results suggest that USP36 interacts with PrimPol at stressed replication forks in cells."
33237263
sparser
"Cancer cells generally have higher replication stress, and the USP36-PrimPol axis might be required to adapt to this stress."
33237263
sparser
"Few dots that represent the interaction of USP36 and PrimPol were observed in the nuclei in unstressed cells."
33237263
sparser
"Moreover, treatment with the replication-damaging agent hydroxyurea (HU) promoted the interaction between USP36 and PrimPol (Figure xref , D)."
33237263
sparser
"In light of the above findings, we tested whether USP36 might physically interact with PrimPol in cells."
33237263
sparser
"Next, we tested whether these two lysine residues (K329R and K338R) were essential for the regulation of USP36-PrimPol interaction."
33237263
sparser
"We further confirmed the close interaction between USP36 and PrimPol by proximity ligation assay (PLA)."
33237263
MYCN affects USP36
| 5 5
USP36 binds MYCN. 10 / 10
| 5 5
reach
"We found that endogenous MYCN interacts with USP36 in both of the cells lines (XREF_FIG, left and middle panels)."
34056606
sparser
"We found that endogenous MYCN interacts with USP36 in both of the cells lines ( xref , left and middle panels)."
34056606
sparser
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE(2) and IMR-32 cell lines."
34056606
sparser
"Considering that the ubiquitin-specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
reach
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 (XREF_FIG, right panel)."
34056606
reach
"These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN."
34056606
sparser
"USP36 Interacts With MYCN and Regulates Its Stability by Deubiquitination."
34056606
sparser
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 ( xref , right panel)."
34056606
reach
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE (2) and IMR-32 cell lines."
34056606
reach
"Considering that the ubiquitin specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
MYC affects USP36
2 4 | 2 1
MYC binds USP36.
4 | 1 1
USP36 binds MYC. 6 / 6
4 | 1 1
reach
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
sparser
"We further show that USP36 itself is a c-Myc target gene, suggesting that USP36 and c-Myc form a positive feedback regulatory loop."
25775507
MYC decreases the amount of USP36.
2 |
MYC decreases the amount of USP36. 2 / 3
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
MYC inhibits USP36.
| 1
MYC inhibits USP36. 1 / 1
| 1
reach
"Upregulation of c-MYC reversed the downregulation of hnRNPH1/H2 induced inhibition of USP36."
35133629
Circ affects USP36
| 9
USP36 binds circ. 9 / 9
| 9
sparser
"The targets of circ-USP36 and miR-98-5p were searched using starBase website, and dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were applied to validate the above predictions."
33249762
sparser
"We aim to uncover the role of circ-ubiquitin specific peptidase 36 (USP36) in autophagic granulosa cell death."
35964538
sparser
"MiR-98-5p was a direct downstream gene of circ-USP36."
33249762
sparser
"Circ-USP36 promoted the injury of ox-LDL-induced HUVEC cells through targeting miR-98-5p."
33249762
sparser
"Ox-LDL exposure induced the upregulation of circ-USP36 in HUVEC cells."
33249762
sparser
"Ox-LDL promoted the apoptosis and inflammation but suppressed the viability of HUVEC cells through upregulating circ-USP36, thus elevating the expression of VCAM1 via miR-98-5p."
33249762
sparser
"The levels of circ-USP36, microRNA-98-5p (miR-98-5p) and vascular cell adhesion molecule 1 (VCAM1) were examined by a quantitative real-time polymerase chain reaction (qRT-PCR)."
33249762
sparser
"This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL)."
33249762
sparser
"Circ-USP36 accelerated ox-LDL-induced apoptosis, inflammatory and viability inhibition of HUVEC cells."
33249762
USP36 affects Histone_H2B
| 2 6
USP36 binds Histone_H2B.
| 1 6
sparser
"USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
sparser
"Together, we conclude that USP36 interacts with H2B in cells and in vitro and that this likely occurs within the context of chromatin."
29274341
sparser
"The interaction of USP36 with H2B likely occurs within the context of chromatin as we found that a significant pool of USP36 is enriched on chromatin."
29274341
sparser
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
sparser
"USP36 interacts with H2B."
29274341
GST binds Histone_H2B and USP36. 1 / 1
| 1
sparser
"As shown in xref , H2B bound GST-USP36 1-800 , but not GST alone."
29274341
USP36 deubiquitinates Histone_H2B.
| 1
USP36 deubiquitinates Histone_H2B. 1 / 1
| 1
reach
"Scrawny is an ubiquitin specific protease, homologue of human USP36 and yeast UBP10, which deubiquitylates histone H2B and functions in gene silencing."
25294944
USP36 affects DOCK4
| 6 2
USP36 deubiquitinates DOCK4.
| 3
USP36 leads to the deubiquitination of DOCK4. 3 / 3
| 3
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/beta-catenin signaling pathway and induce EMT."
33968925
reach
"Further, we found that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT."
33968925
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
USP36 binds DOCK4.
| 1 2
DOCK4 binds USP36. 3 / 3
| 1 2
sparser
"First, we evidenced that USP36 physically interacts with DOCK4 by IP and in situ proximity ligation assay ( in situ PLA) ( xref )."
33968925
reach
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed (Figures 4B,C)."
33968925
sparser
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed ( xref )."
33968925
USP36 increases the amount of DOCK4.
| 2
USP36 increases the amount of DOCK4. 2 / 2
| 2
reach
"To study the effect of USP36 on the expression of DOCK4, we evidenced the protein level of DOCK4 was significantly reduced or elevated by knockdown or overexpression of USP36 in TECs (Figures 4E,F)."
33968925
reach
"Then, the data showed that the ubiquitination level of DOCK4 was significantly increased or decreased by knockdown or overexpression of USP36 in TECs (Figures 4G–J)."
33968925
USP36 affects autophagy
| 6 1
USP36 inhibits autophagy. 7 / 7
| 6 1
reach
"As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation."
28350092
sparser
"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
26445063
reach
"USP36 seems to antagonize different autophagy related processes in a context dependent manner."
26445063
reach
"A prior study revealed that silencing of USP36, one of the deubiquitinating enzymes, could trigger selective autophagy via a p62 dependent pathway."
28350092
reach
"On the contrary, silencing of USP36 triggered autophagy via a p62 dependent pathway."
28350092
reach
"The deletion of USP36 of Drosophila melanogaster results in an inhibition of larval growth and activated constitutively autophagy in an mTOR independent manner."
26445063
reach
"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
26445063
USP36 affects NPM1
5 | 2
USP36 binds NPM1.
5 |
USP36 binds NPM1. 5 / 5
5 |
biogrid
No evidence text available
19679658
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19679658
biogrid
No evidence text available
19679658
USP36 deubiquitinates NPM1.
| 2
USP36 deubiquitinates NPM1. 2 / 2
| 2
reach
"We also tested whether a nucleolar deubiquitinase USP36, which deubiquitinates NPM XREF_BIBR, affects the MG132 caused NPM nucleolar retention in the UV treated cells."
23554979
reach
"It was shown that NPM1 is deubiquitinated by USP36 (ubiquitin specific peptidase 36) in the nucleolus stabilizing NPM1 [52], which is in turn required for USP36 accumulation [53]."
29157973
Histone_H2B affects USP36
| 1 6
sparser
"USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
sparser
"Together, we conclude that USP36 interacts with H2B in cells and in vitro and that this likely occurs within the context of chromatin."
29274341
sparser
"The interaction of USP36 with H2B likely occurs within the context of chromatin as we found that a significant pool of USP36 is enriched on chromatin."
29274341
sparser
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
sparser
"USP36 interacts with H2B."
29274341
GST binds Histone_H2B and USP36. 1 / 1
| 1
sparser
"As shown in xref , H2B bound GST-USP36 1-800 , but not GST alone."
29274341
USP36 activates cell population proliferation. 5 / 6
| 1 4
eidos
"Depletion of USP36 by shRNA in SK-N-BE ( 2 ) and IMR-32 resulted in a decrease in cell proliferation ( Figure 3A ) and reduced colony formation ( Figure 3B ) ."
34056606
reach
"As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation."
28350092
reach
"Overexpression of USP36 promoted NSCLC cell proliferation and inhibited NSCLC cell apoptosis."
35133629
reach
"Similar to the growth deficit, we observed with ubp10Delta yeast cells, knockdown of USP36 levels reduced proliferation of HeLa cells, and deletion of scrawny reduced the proliferation of follicle and intestinal stem cells in Drosophila."
22902402
reach
"USP36 Promotes NB Cell Proliferation and Tumor Phenotype."
34056606
NPM1 affects USP36
5 | 1
NPM1 binds USP36.
5 |
USP36 binds NPM1. 5 / 5
5 |
biogrid
No evidence text available
19679658
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19679658
biogrid
No evidence text available
19679658
NPM1 activates USP36.
| 1
NPM1 activates USP36. 1 / 1
| 1
reach
"Interestingly, NPM1 itself can target USP36 to nucleoli by direct binding [XREF_BIBR]."
21152184
USP36 affects SOD2
3 1 | 1
USP36 binds SOD2.
3 | 1
SOD2 binds USP36. 4 / 4
3 | 1
biogrid
No evidence text available
21268071
sparser
"As shown in xref b, USP36 associated with immunoprecipitated SOD2 at 2 h, but not at 4 h, indicating a transient interaction between the two molecules, in line with the transient increase in SOD2 levels."
34207085
biogrid
No evidence text available
21268071
biogrid
No evidence text available
21268071
USP36 deubiquitinates SOD2.
1 |
USP36 deubiquitinates SOD2. 1 / 1
1 |
ubibrowser
"we identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2"
21268071
USP36 affects PPME1
1 | 1 2 1
USP36 activates PPME1.
| 1 1
USP36 activates PPME1. 2 / 2
| 1 1
eidos
"Hence , we speculate that the up-regulation of PME-1 in HCC may be due to USP36 , which need further verified ."
32431540
reach
"USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level."
29577269
USP36 deubiquitinates PPME1.
1 |
USP36 deubiquitinates PPME1. 1 / 1
1 |
ubibrowser
"we demonstrate that USP36 regulates PME-1 through its deubiquitinating enzyme activity. USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level."
29577269
USP36 decreases the amount of PPME1.
| 1
USP36 decreases the amount of PPME1. 1 / 1
| 1
reach
"USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level."
29577269
USP36 binds PPME1.
| 1
USP36 binds PPME1. 1 / 1
| 1
sparser
"A previous study demonstrates that deubiquitinating enzyme USP36 binds to and regulates PME-1 through its deubiquitinating enzyme activity. xref Analysis of USP36 protein expression in clinical specimens from the Human Protein Atlas () showed that USP36 is a high expression in HCC."
32431540
USP36 affects DGCR8
| 4 1
USP36 sumoylates DGCR8.
| 3 1
USP36 sumoylates DGCR8. 4 / 4
| 3 1
sparser
"USP36 interacts with the microprocessor complex and promotes DGCR8 SUMOylation, specifically modified by SUMO2."
36950067
reach
"USP36 interacts with the microprocessor complex and promotes DGCR8 SUMOylation, specifically modified by SUMO2."
36950067
reach
"The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8."
36950067
reach
"This study identifies that USP36 mediates DGCR8 SUMOylation by SUMO2 and is critical for miRNA biogenesis."
36950067
USP36 increases the amount of DGCR8.
| 1
USP36 increases the amount of DGCR8. 1 / 1
| 1
reach
"USP36-mediated SUMOylation does not affect the levels of DGCR8 and the formation of the Drosha-DGCR8 complex, but promotes the binding of DGCR8 to pri-miRNAs."
36950067
Pirinixic acid affects USP36
4 |
Pirinixic acid decreases the amount of USP36.
2 |
Pirinixic acid decreases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
21318169
ctd
No evidence text available
23811191
Pirinixic acid increases the amount of USP36.
1 |
Pirinixic acid increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates USP36.
1 |
Pirinixic acid activates USP36. 1 / 1
1 |
ctd
No evidence text available
19710929
USP36 activates epithelial to mesenchymal transition. 3 / 3
| 3
reach
"Zhu et al. reported that the expression of ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, was induced in DKD in human and murine model and in HG-treated TECs, and the overexpression of USP36 enhanced EMT in TECs."
35082683
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
reach
"The results revealed that DOCK4 knockdown effectively abolished USP36 overexpression-induced EMT through suppressing Wnt/β-catenin signaling pathway in TECs (Figures 5M,N)."
33968925
USP36 inhibits epithelial to mesenchymal transition. 1 / 1
| 1
reach
"Our present study revealed the increased DOCK4 expression both in vivo and in vitro in circumstance of high-glucose, while knockdown of DOCK4 could reverse the overexpression of USP36 induced EMT effect, indicating a role of DOCK4 played in diabetic renal fibrosis."
33968925
USP36 affects H2Bub1
| 4
USP36 deubiquitinates H2Bub1.
| 1
USP36 deubiquitinates H2Bub1. 1 / 1
| 1
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
USP36 decreases the amount of H2Bub1.
| 1
Modified USP36 decreases the amount of H2Bub1. 1 / 1
| 1
reach
"Overexpression of USP36 markedly reduced the levels of H2Bub1 in cells."
29274341
USP36 binds H2Bub1.
| 1
USP36 binds H2Bub1. 1 / 1
| 1
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
USP36 activates H2Bub1.
| 1
USP36 activates H2Bub1. 1 / 1
| 1
reach
"Using the p21 gene as a model, we demonstrate that depletion of USP36 increases H2Bub1 at the p21 locus, primarily within its gene body."
29274341
USP36 affects DHX33
3 1 |
USP36 binds DHX33.
3 |
DHX33 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
USP36 deubiquitinates DHX33.
1 |
USP36 deubiquitinates DHX33. 1 / 1
1 |
ubibrowser
"Collectively, these results support that Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability."
29273634
SOD2 affects USP36
3 | 1
SOD2 binds USP36. 4 / 4
3 | 1
biogrid
No evidence text available
21268071
sparser
"As shown in xref b, USP36 associated with immunoprecipitated SOD2 at 2 h, but not at 4 h, indicating a transient interaction between the two molecules, in line with the transient increase in SOD2 levels."
34207085
biogrid
No evidence text available
21268071
biogrid
No evidence text available
21268071
DOCK4 affects USP36
| 2 2
DOCK4 binds USP36.
| 1 2
DOCK4 binds USP36. 3 / 3
| 1 2
sparser
"First, we evidenced that USP36 physically interacts with DOCK4 by IP and in situ proximity ligation assay ( in situ PLA) ( xref )."
33968925
reach
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed (Figures 4B,C)."
33968925
sparser
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed ( xref )."
33968925
DOCK4 increases the amount of USP36.
| 1
DOCK4 increases the amount of USP36. 1 / 1
| 1
reach
"Our present study revealed the increased DOCK4 expression both in vivo and in vitro in circumstance of high-glucose, while knockdown of DOCK4 could reverse the overexpression of USP36 induced EMT effect, indicating a role of DOCK4 played in diabetic renal fibrosis."
33968925
Cisplatin affects USP36
3 |
Cisplatin decreases the amount of USP36.
2 |
Cisplatin decreases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
27594783
ctd
No evidence text available
27392435
Cisplatin increases the amount of USP36.
1 |
Cisplatin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20849824
USP36 affects rRNA processing
| 1 1 1
USP36 activates rRNA processing.
| 1 1
USP36 activates rRNA processing. 1 / 1
| 1
eidos
"Functionally , we show that knockdown of USP36 markedly impairs rRNA processing and translation ."
33852194
USP36 activates rRNA processing. 1 / 1
| 1
reach
"Functionally, we show that knockdown of USP36 markedly impairs rRNA processing and translation."
33852194
USP36 sumoylates rRNA processing.
| 1
USP36 sumoylates rRNA processing. 1 / 1
| 1
sparser
"The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing."
36912080
USP36 affects apoptotic process
| 3
USP36 inhibits apoptotic process.
| 2
reach
"Overexpression of USP36 promoted NSCLC cell proliferation and inhibited NSCLC cell apoptosis."
35133629
reach
"Importantly, we found that overexpression of USP36 markedly decreased ischemia induced apoptosis and oxidative stress in HK-2cells, which was accompanied by elevated c-Myc and SOD2 protein levels with alleviated ischemia induced ubiquitination of both proteins."
30975468
USP36 activates apoptotic process.
| 1
USP36 activates apoptotic process. 1 / 1
| 1
reach
"Moreover, northern blot analysis has shown that USP36 deficiency induces aberrations in rRNA synthesis and apoptosis at the preimplantation stage of development."
33518352
USP36 affects Flag
| 3
USP36 binds Flag. 3 / 3
| 3
sparser
"To determine whether USP36 directly deubiquitinates Snail2, we co-transfected HEK293T cells with His-Snail2, HA-ubiquitin and Flag-USP36 (WT or C131A)."
35111679
sparser
"Conversely, PrimPol stability was significantly increased in HEK293T cells stably expressing Flag-USP36 ( xref )."
33237263
sparser
"PrimPol was also detected in immunoprecipitates using anti-Flag agarose beads from cells expressed Flag-USP36 (Figure xref )."
33237263
USP36 affects FBXW7
2 |
FBXW7 binds USP36. 2 / 3
2 |
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
USP36 affects COPS3
| 3
USP36 binds COPS3. 3 / 3
| 3
sparser
"Mechanistically, anakinra appears to have prevented SOD2 degradation by interfering with the USP36-COPS3 complex rather than inducing its expression."
34207085
sparser
"The induction of SOD2 was selective, as other antioxidant enzymes did not appear to be modulated by anakinra, as occurs for other SOD2 mimetics, an effect that may be related to the ability of anakinra to interfere with the USP36-COPS3 complex, rather than engaging the Nrf2 pathway [ xref ]."
34207085
sparser
"Anakinra Prevents SOD2 Degradation via USP36-COPS3."
34207085
Flag affects USP36
| 3
USP36 binds Flag. 3 / 3
| 3
sparser
"To determine whether USP36 directly deubiquitinates Snail2, we co-transfected HEK293T cells with His-Snail2, HA-ubiquitin and Flag-USP36 (WT or C131A)."
35111679
sparser
"Conversely, PrimPol stability was significantly increased in HEK293T cells stably expressing Flag-USP36 ( xref )."
33237263
sparser
"PrimPol was also detected in immunoprecipitates using anti-Flag agarose beads from cells expressed Flag-USP36 (Figure xref )."
33237263
FBXW7 affects USP36
2 |
FBXW7 binds USP36. 2 / 3
2 |
biogrid
No evidence text available
25775507
biogrid
No evidence text available
25775507
DHX33 affects USP36
3 |
DHX33 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
COPS3 affects USP36
| 3
USP36 binds COPS3. 3 / 3
| 3
sparser
"Mechanistically, anakinra appears to have prevented SOD2 degradation by interfering with the USP36-COPS3 complex rather than inducing its expression."
34207085
sparser
"The induction of SOD2 was selective, as other antioxidant enzymes did not appear to be modulated by anakinra, as occurs for other SOD2 mimetics, an effect that may be related to the ability of anakinra to interfere with the USP36-COPS3 complex, rather than engaging the Nrf2 pathway [ xref ]."
34207085
sparser
"Anakinra Prevents SOD2 Degradation via USP36-COPS3."
34207085
Titanium dioxide affects USP36
2 |
Titanium dioxide increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
29264374
ctd
No evidence text available
31298478
Nucleolar Fbw7gamma affects USP36
| 2
USP36 binds nucleolar Fbw7gamma. 2 / 2
| 2
reach
"Interestingly, USP36 interacts with the nucleolar Fbw7gamma but not the nucleoplasmic Fbw7alpha."
25775507
reach
"USP36, a highly expressed USP in a subset of human breast and lung cancers, could interact with the nucleolar Fbw7gamma and maintain c-Myc stability in the nucleolus."
33643919
HnRNPH1/H2 affects USP36
| 2
HnRNPH1/H2 inhibits USP36. 2 / 2
| 2
reach
"Overexpression of hnRNPH1/H2 reversed the downregulation of KHK-A induced inhibition of USP36."
35133629
reach
"Upregulation of c-MYC reversed the downregulation of hnRNPH1/H2 induced inhibition of USP36."
35133629
Cyclosporin A affects USP36
2 |
Cyclosporin A increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
25562108
ctd
No evidence text available
20106945
Bisphenol A affects USP36
2 |
Bisphenol A increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
25181051
ctd
No evidence text available
26063408
USP36 affects α-SMA
| 2
USP36 inhibits α-SMA.
| 1
USP36 inhibits α-SMA. 1 / 1
| 1
reach
"As shown in Figures 3D,E, E-cadherin was significantly enhanced and α-SMA was obviously decreased by knockdown of USP36 in TECs."
33968925
USP36 increases the amount of α-SMA.
| 1
USP36 increases the amount of α-SMA. 1 / 1
| 1
reach
"As shown in Figures 3F,G, E-cadherin was obviously decreased and α-SMA was significantly enhanced in TECs under high glucose, while knockdown of USP36 could effectively reverse the expression of E-cadherin and α-SMA, which suggesting that up-regulation of USP36 may be an upstream mechanism for EMT and diabetic tubulointerstitial fibrosis."
33968925
USP36 affects translation
| 1 1
USP36 activates translation. 2 / 2
| 1 1
reach
"Functionally, we show that knockdown of USP36 markedly impairs rRNA processing and translation."
33852194
eidos
"Functionally , we show that knockdown of USP36 markedly impairs rRNA processing and translation ."
33852194
sparser
"The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis."
33852194
sparser
"Thus, USP36 promotes snoRNP group SUMOylation and is critical for ribosome biogenesis and protein translation."
33852194
USP36 affects nucleolar Fbw7gamma
| 2
USP36 binds nucleolar Fbw7gamma. 2 / 2
| 2
reach
"Interestingly, USP36 interacts with the nucleolar Fbw7gamma but not the nucleoplasmic Fbw7alpha."
25775507
reach
"USP36, a highly expressed USP in a subset of human breast and lung cancers, could interact with the nucleolar Fbw7gamma and maintain c-Myc stability in the nucleolus."
33643919
USP36 activates myasthenia gravis anti-skeletal muscle antibody. 2 / 2
| 2
eidos
"As shown in Figures 3F , G , E-cadherin was obviously decreased and alpha-SMA was significantly enhanced in TECs under high glucose , while knockdown of USP36 could effectively reverse the expression of E-cadherin and alpha-SMA , which suggesting that up-regulation of USP36 may be an upstream mechanism for EMT and diabetic tubulointerstitial fibrosis ."
33968925
eidos
"As shown in Figures 3D , E , E-cadherin was significantly enhanced and alpha-SMA was obviously decreased by knockdown of USP36 in TECs ."
33968925
USP36 affects c-Myc [
| 2
USP36 deubiquitinates c-Myc [.
| 1
USP36 deubiquitinates c-Myc [. 1 / 1
| 1
reach
"In a subset of human breast and lung cancers, USP36 interacts with and deubiquitinates c-Myc [XREF_BIBR]."
29142505
USP36 binds c-Myc [.
| 1
USP36 binds c-Myc [. 1 / 1
| 1
reach
"In a subset of human breast and lung cancers, USP36 interacts with and deubiquitinates c-Myc [XREF_BIBR]."
29142505
USP36 affects Wnt/β-catenin
| 2
USP36 inhibits Wnt/β-catenin. 2 / 2
| 2
reach
"The results revealed that DOCK4 knockdown effectively abolished USP36 overexpression-induced EMT through suppressing Wnt/β-catenin signaling pathway in TECs (Figures 5M,N)."
33968925
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
USP36 affects Ubiquitin
| 2
USP36 inhibits Ubiquitin.
| 1
USP36 inhibits Ubiquitin. 1 / 1
| 1
reach
"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
26445063
USP36 activates Ubiquitin.
| 1
USP36 activates Ubiquitin. 1 / 1
| 1
reach
"Ten years after the initial GWAS, we now have a better mechanistic understanding of this genetic predisposition as CASC15 and NBAT-1 were shown to modulate the localization of the Ubiquitin-Specific Protease 36 (USP36) [87]."
30200332
USP36 affects UBE2I
| 1 1
UBE2I binds USP36. 1 / 1
| 1
reach
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
SUMO2 binds UBE2I and USP36. 1 / 1
| 1
sparser
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
USP36 affects SOX9
| 1 1
USP36 deubiquitinates SOX9.
| 1
USP36 deubiquitinates SOX9. 1 / 1
| 1
reach
"When these two long noncoding RNAs are lost, CHD7 is de-ubiquitinated by USP36 and then interacts with SOX9 to maintain a de-differentiated cellular state."
30200332
USP36 binds SOX9.
| 1
SOX9 binds USP36. 1 / 1
| 1
sparser
"Recent data shows that CASC15 and NBAT1 promote differentiation by interactions with SOX9 and USP36 , located on chromosome 17q that is frequently gained in high-risk neuroblastomas."
30760980
USP36 affects SNAI2
| 2
SNAI2 binds USP36. 2 / 2
| 2
sparser
"Co-immunoprecipitation (Co-IP) confirmed that both wild type and mutant USP36 bound to Snail2 ( xref ), indicating that the DUB activity of USP36 was independent of its interaction with Snail2."
35111679
sparser
"To determine whether USP36 directly interacts with Snail2, HEK293T cells were co-transfected with Flag-tagged USP36-WT or USP36-C131A along with His-tagged Snail2."
35111679
USP36 affects RAP80-BRCA1
| 1 1
USP36 inhibits RAP80-BRCA1. 2 / 2
| 1 1
reach
"USP37 and USP36 prevent excessive spreading of RAP80-BRCA1 from DSBs."
| PMC
eidos
"USP37 and USP36 prevent excessive spreading of RAP80-BRCA1 from DSBs ."
| PMC
USP36 affects POLR1A
1 | 1
USP36 deubiquitinates POLR1A.
1 |
USP36 deubiquitinates POLR1A. 1 / 1
1 |
ubibrowser
"?In particular, we discovered that the largest subunit of RNA polymerase I (RNAPI) is stabilized via Ubp10-mediated deubiquitination.|USP36, the human ortholog of Ubp10, complements the ubp10螖 allele for RNAPI stability, pre-rRNA processing, and cell growth in yeast, suggesting that deubiquitination of RNAPI may be conserved in eukaryotes."
22902402
USP36 activates POLR1A.
| 1
USP36 activates POLR1A. 1 / 1
| 1
reach
"Overexpression of USP36 effectively blocked RPA194 degradation, while that of HAUSP did not (XREF_FIG)."
24434211
USP36 affects Neoplasms
| 1 1
USP36 activates Neoplasms. 2 / 2
| 1 1
eidos
"Depletion of USP36 significantly reduced the tumor weight , tumor volume and Ki67 staining , indicating that USP36 harbors oncogenic properties ( Figure 3C and D ) ."
34056606
reach
"In summary, overexpression of USP36 in NSCLC accelerated tumor growth through upregulation of KHK-A, which was medicated by stabilizing c-MYC to increase hnRNPH1/H2 expression."
35133629
USP36 affects NTRK1
| 2
USP36 increases the amount of NTRK1.
| 1
USP36 increases the amount of NTRK1. 1 / 1
| 1
reach
"Moreover, USP36 depletion leads to enhanced total and surface TrkA expression that results in increased NGF mediated TrkA activation and signaling that augments PC12 cell differentiation."
27445338
USP36 deubiquitinates NTRK1.
| 1
Modified USP36 leads to the deubiquitination of NTRK1. 1 / 1
| 1
reach
"Instead, USP36 interfered with the binding of Nedd4-2 to TrkA, and hence USP36 expression impaired the Nedd4-2-mediated ubiquitination of TrkA [XREF_BIBR]."
28335430
USP36 affects NT5E
2 |
USP36 binds NT5E. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP36 affects NOP58
| 1 1
USP36 leads to the sumoylation of NOP58. 2 / 2
| 1 1
reach
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs."
33852194
sparser
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs."
33852194
USP36 affects NEDD4L
| 1
USP36 binds NEDD4L. 1 / 2
| 1
reach
"Instead, USP36 binds to Nedd4-2 and regulates the association of TrkA and Nedd4-2."
27445338
USP36 affects KIAA0232
2 |
USP36 binds KIAA0232. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP36 affects Imd
| 2
USP36 inhibits Imd.
| 1
USP36 inhibits Imd. 1 / 1
| 1
reach
"We report here that USP2 and USP34 and Puf, in addition to the previously described USP36 and Scny, prevent inappropriate activation of Imd dependent immune signal in unchallenged conditions."
25027767
USP36 deubiquitinates Imd.
| 1
USP36 deubiquitinates Imd. 1 / 1
| 1
reach
"USP36 deubiquitinates Imd for its degradation and, thus, represses Imd signaling."
25858029
USP36 affects IMD
| 2
USP36 inhibits IMD. 2 / 2
| 2
reach
"Another recent study demonstrated that the deubiquitinating enzyme Usp36, which had been shown to negatively regulate the IMD pathway in flies, also negatively regulates p62 dependent selective autophagy in flies and human cells [XREF_BIBR]."
23689401
reach
"USP36 removes K63-polyubiquitin chains from IMD and then appears to increase the addition of K48-ubiquitin chains and degradation of IMD."
20852987
USP36 affects GST
| 2
GST binds USP36 and USP. 1 / 1
| 1
sparser
"The polyubiquitinated PrimPol was incubated with purified recombinant USP domain-containing GST-USP36 1–800 (WT or CA) or control buffer followed by immunoblot with anti-Ub antibody."
33237263
GST binds Histone_H2B and USP36. 1 / 1
| 1
sparser
"As shown in xref , H2B bound GST-USP36 1-800 , but not GST alone."
29274341
USP36 affects GEF
| 2
USP36 leads to the deubiquitination of GEF. 2 / 2
| 2
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/beta-catenin signaling pathway and induce EMT."
33968925
reach
"Further, we found that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT."
33968925
USP36 affects ERK
| 2
USP36 activates ERK. 2 / 2
| 2
reach
"The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways."
32220889
reach
"Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways."
29577269
USP36 affects CELSR2
2 |
USP36 binds CELSR2. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
USP36 affects C-MYC
| 2
USP36 deubiquitinates C-MYC.
| 1
USP36 deubiquitinates C-MYC. 1 / 1
| 1
trips
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
USP36 binds C-MYC.
| 1
USP36 binds C-MYC. 1 / 1
| 1
trips
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
USP36 affects ALKBH5
| 2
USP36 binds ALKBH5. 2 / 2
| 2
sparser
"Mass spectrometry and immunoprecipitation were performed to identify the USP36 and ALKBH5 interaction."
36239338
sparser
"Our findings indicate that USP36 regulates the protein degradation and expression of ALKBH5, and the USP36-ALKBH5 axis orchestrates glioma tumorigenesis."
36239338
USP36 affects AKT
| 2
USP36 activates AKT. 2 / 2
| 2
reach
"Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways."
29577269
reach
"The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways."
32220889
UBE2I affects USP36
| 1 1
UBE2I binds USP36. 1 / 1
| 1
reach
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
SUMO2 binds UBE2I and USP36. 1 / 1
| 1
sparser
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
SNAI2 affects USP36
| 2
SNAI2 binds USP36. 2 / 2
| 2
sparser
"Co-immunoprecipitation (Co-IP) confirmed that both wild type and mutant USP36 bound to Snail2 ( xref ), indicating that the DUB activity of USP36 was independent of its interaction with Snail2."
35111679
sparser
"To determine whether USP36 directly interacts with Snail2, HEK293T cells were co-transfected with Flag-tagged USP36-WT or USP36-C131A along with His-tagged Snail2."
35111679
NT5E affects USP36
2 |
USP36 binds NT5E. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
NEDD4L affects USP36
| 1
USP36 binds NEDD4L. 1 / 2
| 1
reach
"Instead, USP36 binds to Nedd4-2 and regulates the association of TrkA and Nedd4-2."
27445338
KIAA0232 affects USP36
2 |
USP36 binds KIAA0232. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
JQ1 affects USP36
| 2
JQ1 activates USP36. 2 / 2
| 2
reach
"Unbiased integration of RNA-seq data from CASC15-003, NBAT1, USP36, and MYCN knockdowns and neuroblastoma cells treated with MYCN inhibitor JQ1, identified genes that are jointly regulated by the NBAT1/CASC15-003/USP36/MYCN pathway."
34056606
reach
"These novel MYCN dependent pathways were obtained following an unbiased integration of RNA-seq datasets from CASC15-003, NBAT1, USP36, and MYCN knockdowns and NB cells treated with the MYCN inhibitor JQ1."
34056606
GST affects USP36
| 2
GST binds USP36 and USP. 1 / 1
| 1
sparser
"The polyubiquitinated PrimPol was incubated with purified recombinant USP domain-containing GST-USP36 1–800 (WT or CA) or control buffer followed by immunoblot with anti-Ub antibody."
33237263
GST binds Histone_H2B and USP36. 1 / 1
| 1
sparser
"As shown in xref , H2B bound GST-USP36 1-800 , but not GST alone."
29274341
CREB1 affects USP36
2 |
CREB1 decreases the amount of USP36. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
CELSR2 affects USP36
2 |
USP36 binds CELSR2. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
ALKBH5 affects USP36
| 2
USP36 binds ALKBH5. 2 / 2
| 2
sparser
"Mass spectrometry and immunoprecipitation were performed to identify the USP36 and ALKBH5 interaction."
36239338
sparser
"Our findings indicate that USP36 regulates the protein degradation and expression of ALKBH5, and the USP36-ALKBH5 axis orchestrates glioma tumorigenesis."
36239338
Zinc atom affects USP36
1 |
Zinc atom increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
18593933
Vorinostat affects USP36
1 |
Vorinostat decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
27188386
Tunicamycin affects USP36
1 |
Tunicamycin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
22378314
Tris(1,3-dichloro-2-propyl)phosphate increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
30157643
Transduction independent hairpin RNAs affects USP36
| 1
Transduction independent hairpin RNAs activates USP36. 1 / 1
| 1
eidos
"To test this hypothesis , USP36 was stably downregulated in SK-N-BE ( 2 ) , IMR-32 , and SHSY5Y cell lines by transduction of 2 independent short hairpin RNAs ( shRNAs ) ."
34056606
Thapsigargin affects USP36
1 |
Thapsigargin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
22378314
Sunitinib affects USP36
1 |
Sunitinib increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
31533062
ShRNA affects USP36
| 1
ShRNA inhibits USP36. 1 / 1
| 1
eidos
"Depletion of USP36 by shRNA in SK-N-BE ( 2 ) and IMR-32 resulted in a decrease in cell proliferation ( Figure 3A ) and reduced colony formation ( Figure 3B ) ."
34056606
Serpentine asbestos demethylates USP36. 1 / 1
1 |
ctd
No evidence text available
29523930
Resveratrol affects USP36
1 |
Resveratrol increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
31298478
Potassium chromate increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
22079256
Methylmercury chloride increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28001369
Methapyrilene affects USP36
1 |
Methapyrilene methylates USP36. 1 / 1
1 |
ctd
No evidence text available
30157460
Mercury dichloride increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
16507785
Melphalan affects USP36
1 |
Melphalan increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
22363485
Lnc-HZ01 affects USP36
| 1
Lnc-HZ01 activates USP36. 1 / 1
| 1
reach
"Mechanistically, lnc-HZ01 promotes MXD1 mRNA transcription by up-regulating its transcription factor c-JUN and also enhances MXD1 protein stability by up-regulating its deubiquitin enzyme USP36."
33647641
Lipoprotein affects USP36
| 1
Lipoprotein activates USP36. 1 / 1
| 1
reach
"This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL)."
33249762
Leflunomide affects USP36
1 |
Leflunomide increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28988120
Indometacin affects USP36
1 |
Indometacin decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28201806
Hsa-miR-98-5p affects USP36
1 |
Hsa-miR-98-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
19088304
Hsa-miR-9500 affects USP36
1 |
Hsa-miR-9500 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-873-3p affects USP36
1 |
Hsa-miR-873-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-7515 affects USP36
1 |
Hsa-miR-7515 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6849-5p affects USP36
1 |
Hsa-miR-6849-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6840-3p affects USP36
1 |
Hsa-miR-6840-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6770-5p affects USP36
1 |
Hsa-miR-6770-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-615-3p affects USP36
1 |
Hsa-miR-615-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-6124 affects USP36
1 |
Hsa-miR-6124 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6080 affects USP36
1 |
Hsa-miR-6080 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6077 affects USP36
1 |
Hsa-miR-6077 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-582-5p affects USP36
1 |
Hsa-miR-582-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-5703 affects USP36
1 |
Hsa-miR-5703 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4531 affects USP36
1 |
Hsa-miR-4531 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4516 affects USP36
1 |
Hsa-miR-4516 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4499 affects USP36
1 |
Hsa-miR-4499 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-4434 affects USP36
1 |
Hsa-miR-4434 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-3681-5p affects USP36
1 |
Hsa-miR-3681-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-342-5p affects USP36
1 |
Hsa-miR-342-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-329-5p affects USP36
1 |
Hsa-miR-329-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-3154 affects USP36
1 |
Hsa-miR-3154 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-151a-3p affects USP36
1 |
Hsa-miR-151a-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-101-5p affects USP36
1 |
Hsa-miR-101-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-101-3p affects USP36
1 |
Hsa-miR-101-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Haloperidol affects USP36
1 |
Haloperidol increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
29458080
HUTP14a affects USP36
| 1
USP36 binds hUTP14a. 1 / 1
| 1
reach
"We further demonstrate that hUTP14a forms a complex with USP36 and Fbw7gamma to inhibit Fbw7gamma mediated c-Myc degradation."
30343112
Gentamycin affects USP36
1 |
Gentamycin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20849824
Geldanamycin affects USP36
1 |
Geldanamycin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
26705709
Fluoranthene affects USP36
1 |
Fluoranthene increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28329830
Fenofibrate affects USP36
1 |
Fenofibrate decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
21318169
Ethanol affects USP36
1 |
Ethanol decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
29361514
Erucylphospho-N,N,N-trimethylpropylammonium increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
29464035
Enzyme inhibitor affects USP36
1 |
ctd
No evidence text available
23301498
Endosulfan affects USP36
1 |
Endosulfan increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
29391264
Dicrotophos affects USP36
1 |
Dicrotophos increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28302478
Cyclophosphamide hydrate increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20849824
Crocidolite asbestos increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
18687144
Cobalt dichloride affects USP36
1 |
Cobalt dichloride increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
19376846
Chlordecone affects USP36
1 |
Chlordecone increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
29458080
Carbon nanotube affects USP36
1 |
Carbon nanotube decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
25554681
C-Myc [ affects USP36
| 1
USP36 binds c-Myc [. 1 / 1
| 1
reach
"In a subset of human breast and lung cancers, USP36 interacts with and deubiquitinates c-Myc [XREF_BIBR]."
29142505
Benzo[e]pyrene affects USP36
1 |
Benzo[e]pyrene methylates USP36. 1 / 1
1 |
ctd
No evidence text available
30157460
Atrazine affects USP36
1 |
Atrazine decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
25929836
Amphotericin B affects USP36
1 |
Amphotericin B increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20849824
All-trans-retinoic acid increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20488242
Aflatoxin B2 affects USP36
1 |
Aflatoxin B2 methylates USP36. 1 / 1
1 |
ctd
No evidence text available
30157460
Aflatoxin B1 affects USP36
1 |
Aflatoxin B1 methylates USP36. 1 / 1
1 |
ctd
No evidence text available
30157460
Abrine affects USP36
1 |
Abrine increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
31054353
YKL078W affects USP36
1 |
USP36 binds YKL078W. 1 / 1
1 |
biogrid
No evidence text available
26149687
YAP1 affects USP36
| 1
YAP1 binds USP36. 1 / 1
| 1
sparser
"Molecular studies demonstrated that USP36 associated with the YAP protein and enhanced YAP protein stability by blocking the K48-linked polyubiquitination of YAP."
36470870
WDR36 affects USP36
1 |
USP36 binds WDR36. 1 / 1
1 |
biogrid
No evidence text available
19615732
WDR3 affects USP36
1 |
WDR3 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
UTP18 affects USP36
1 |
USP36 binds UTP18. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects USP36
| 1
USP36 binds USP39. 1 / 1
| 1
sparser
"Most USPs are abnormally expressed in HCC, among which USP36 and USP39 are most closely associated with HCC prognosis."
35748266
USP36 affects tumor growth
| 1
USP36 activates tumor growth. 1 / 1
| 1
eidos
"Moreover , the DUB USP7 , USP13 , USP22 , USP28 , USP36 and USP37 stabilize c-Myc , thereby stimulating tumor growth [ 155 , 157 , 171-174 ] ."
| PMC
USP36 affects stabilization
| 1
USP36 activates stabilization. 1 / 1
| 1
eidos
"Until now , our hypothesis is that USP36 upregulation causes PrimPol protein deubiquitination and stabilization , which might affect chemotherapy response ."
33237263
USP36 affects stability MYCN
| 1
USP36 activates stability MYCN. 1 / 1
| 1
eidos
"These results indicate that USP36 interacts with and deubiquitinates MYCN , thereby promoting the stability of MYCN ."
34056606
USP36 affects snoRNP group SUMOylation
| 1
USP36 activates snoRNP group SUMOylation. 1 / 1
| 1
eidos
"Thus , USP36 promotes snoRNP group SUMOylation and is critical for ribosome biogenesis and protein translation ."
33852194
reach
"The results revealed that DOCK4 knockdown effectively abolished USP36 overexpression-induced EMT through suppressing Wnt/β-catenin signaling pathway in TECs (Figures 5M,N)."
33968925
USP36 affects replication stress-related defects
| 1
USP36 inhibits replication stress-related defects. 1 / 1
| 1
eidos
"Depletion of USP36 results in replication stress-related defects and elevates cell sensitivity to DNA-damage agents , such as cisplatin and olaparib ."
33237263
USP36 affects reduced colony
| 1
USP36 inhibits reduced colony. 1 / 1
| 1
eidos
"Depletion of USP36 by shRNA in SK-N-BE ( 2 ) and IMR-32 resulted in a decrease in cell proliferation ( Figure 3A ) and reduced colony formation ( Figure 3B ) ."
34056606
USP36 affects protein DOCK4
| 1
USP36 activates protein DOCK4. 1 / 1
| 1
eidos
"To study the effect of USP36 on the expression of DOCK4 , we evidenced the protein level of DOCK4 was significantly reduced or elevated by knockdown or overexpression of USP36 in TECs ( Figures 4E , F ) ."
33968925
reach
"Consistently, abolishing DGCR8 SUMOylation significantly attenuates its binding to pri-miRNAs and knockdown of USP36 attenuates pri-miRNA processing, resulting in marked reduction of tested mature miRNAs."
36950067
USP36 affects polyubiquitination
| 1
USP36 inhibits polyubiquitination. 1 / 1
| 1
eidos
"Using Ub-K29 and its mutant Ub-K29R , we found that the USP36 depletion induced increase in polyubiquitination was abrogated by the Ub-K29R mutation ( Figure 5C ) ."
33237263
USP36 affects polyubiquitination protein
| 1
USP36 activates polyubiquitination protein. 1 / 1
| 1
eidos
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1 , out of which USP29 , USP36 , and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein ."
| PMC
USP36 affects nucleolar SUMOylation
| 1
USP36 activates nucleolar SUMOylation. 1 / 1
| 1
eidos
"Here , we report that USP36 , a nucleolar deubiquitinating enzyme ( DUB ) , promotes nucleolar SUMOylation ."
33852194
USP36 affects macroautophagy
| 1
USP36 inhibits macroautophagy. 1 / 1
| 1
sparser
"USP36 can inhibit selective macroautophagy by preventing the accumulation of ubiquitinated proteins, but the specific substrates of USP36 (whose targeting to autophagosomes is affected) are not yet known [ xref ]."
26415220
USP36 affects localization
| 1
USP36 activates localization. 1 / 1
| 1
reach
"Ten years after the initial GWAS, we now have a better mechanistic understanding of this genetic predisposition as CASC15 and NBAT-1 were shown to modulate the localization of the Ubiquitin-Specific Protease 36 (USP36) [87]."
30200332
USP36 affects hUTP14a
| 1
USP36 binds hUTP14a. 1 / 1
| 1
reach
"We further demonstrate that hUTP14a forms a complex with USP36 and Fbw7gamma to inhibit Fbw7gamma mediated c-Myc degradation."
30343112
USP36 affects guanine
| 1
USP36 leads to the deubiquitination of guanine. 1 / 1
| 1
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt and beta-catenin signaling pathway and induce EMT."
33968925
USP36 affects glucose
| 1
USP36 activates glucose. 1 / 1
| 1
reach
"As shown in Figures 5K,L, western blotting analysis revealed that the expression of β-catenin and α- SMA were significantly increased and E-cad was obviously reduced in high glucose-induced TECs, while these protein expressions were partial reversed by USP36 knockdown."
33968925
USP36 affects fibrillarin
| 1
USP36 deubiquitinates fibrillarin. 1 / 1
| 1
reach
"USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation."
19208757
USP36 leads to the deubiquitination of dedicator of cytokinesis. 1 / 1
| 1
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt and beta-catenin signaling pathway and induce EMT."
33968925
reach
"USP36 is a deubiquitylating enzyme that removes ubiquitin from NPM1 leading to stabilization of NPM1 and improved nucleolar function [XREF_BIBR] while depletion of USP36 impairs ribosome biogenesis."
21152184
USP36 affects cell sensitivity DNA-damage
| 1
USP36 inhibits cell sensitivity DNA-damage. 1 / 1
| 1
eidos
"Depletion of USP36 results in replication stress-related defects and elevates cell sensitivity to DNA-damage agents , such as cisplatin and olaparib ."
33237263
USP36 affects cancer development
| 1
USP36 activates cancer development. 1 / 1
| 1
eidos
"Taken together , these reports suggest that ZRANB1 , USP7 , USP1 and USP36 can promote cancer development via the stabilization of EZH2 by deubiquitination ."
33308321
USP36 affects binding snoRNAs
| 1
USP36 activates binding snoRNAs. 1 / 1
| 1
eidos
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein ( snoRNP ) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs ."
33852194
USP36 affects aberrations
| 1
USP36 inhibits aberrations. 1 / 1
| 1
eidos
"Moreover , northern blot analysis has shown that USP36 deficiency induces aberrations in rRNA synthesis and apoptosis at the preimplantation stage of development ( Fraile et al ., 2018 ) ."
33518352
USP36 affects YKL078W
1 |
USP36 binds YKL078W. 1 / 1
1 |
biogrid
No evidence text available
26149687
USP36 affects YAP1
| 1
YAP1 binds USP36. 1 / 1
| 1
sparser
"Molecular studies demonstrated that USP36 associated with the YAP protein and enhanced YAP protein stability by blocking the K48-linked polyubiquitination of YAP."
36470870
USP36 affects WDR6
| 1
Modified USP36 increases the amount of WDR6. 1 / 1
| 1
reach
"Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY)."
26206755
USP36 affects WDR36
1 |
USP36 binds WDR36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects WDR3
1 |
WDR3 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects UTP18
1 |
USP36 binds UTP18. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects USP39
| 1
USP36 binds USP39. 1 / 1
| 1
sparser
"Most USPs are abnormally expressed in HCC, among which USP36 and USP39 are most closely associated with HCC prognosis."
35748266
USP36 affects USP
| 1
GST binds USP36 and USP. 1 / 1
| 1
sparser
"The polyubiquitinated PrimPol was incubated with purified recombinant USP domain-containing GST-USP36 1–800 (WT or CA) or control buffer followed by immunoblot with anti-Ub antibody."
33237263
USP36 affects Talpha1
| 1
USP36 inhibits Talpha1. 1 / 1
| 1
reach
"The depletion of USP36 by RNA interference abrogated the rescuing effect of Talpha1 on mature p.Phe508del-CFTR, while its over-expression further increased the capacity of Talpha1 to rescue mutated CFTR (XREF_FIG)."
28394330
USP36 affects TRIM26
1 |
TRIM26 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP36 affects TRIM25
1 |
TRIM25 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
29117863
USP36 affects TMEM104
1 |
USP36 binds TMEM104. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects TBL3
1 |
TBL3 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects SUMOylation nucleolar ribonucleoprotein snoRNP components Nop58 Nhp2 cells
| 1
USP36 activates SUMOylation nucleolar ribonucleoprotein snoRNP components Nop58 Nhp2 cells. 1 / 1
| 1
eidos
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein ( snoRNP ) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs ."
33852194
USP36 affects SUMOylation cells
| 1
USP36 activates SUMOylation cells. 1 / 1
| 1
eidos
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro ."
33852194
USP36 affects SUMO3
| 1
SUMO3 binds USP36. 1 / 1
| 1
reach
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
USP36 affects SUMO2
| 1
SUMO2 binds UBE2I and USP36. 1 / 1
| 1
sparser
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
USP36 affects STK25
1 |
STK25 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects SRPK2
1 |
SRPK2 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
26167880
USP36 affects SQSTM1
| 1
USP36 inhibits SQSTM1. 1 / 1
| 1
reach
"Another recent study demonstrated that the deubiquitinating enzyme Usp36, which had been shown to negatively regulate the IMD pathway in flies, also negatively regulates p62 dependent selective autophagy in flies and human cells [XREF_BIBR]."
23689401
USP36 affects SNAI1
| 1
USP36 leads to the deubiquitination of SNAI1. 1 / 1
| 1
reach
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1, out of which USP29, USP36, and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein."
| PMC
USP36 affects SHPRH
1 |
SHPRH binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
reach
"Zhu et al. reported that the expression of ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, was induced in DKD in human and murine model and in HG-treated TECs, and the overexpression of USP36 enhanced EMT in TECs."
35082683
USP36 affects RPL10
1 |
RPL10 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP36 affects Protein Stability
| 1
USP36 activates Protein Stability. 1 / 1
| 1
eidos
"USP36 deubiquitinates K29-linked polyubiquitination of PrimPol and increases its protein stability ."
33237263
USP36 affects Protease
| 1
USP36 activates Protease. 1 / 1
| 1
reach
"Ten years after the initial GWAS, we now have a better mechanistic understanding of this genetic predisposition as CASC15 and NBAT-1 were shown to modulate the localization of the Ubiquitin-Specific Protease 36 (USP36) [87]."
30200332
USP36 affects PrimPol protein
| 1
USP36 activates PrimPol protein. 1 / 1
| 1
eidos
"Among all of them , USP36 was identified to induce the most significant upregulation to PrimPol protein level ."
33237263
USP36 affects PrimPol protein deubiquitination
| 1
USP36 activates PrimPol protein deubiquitination. 1 / 1
| 1
eidos
"Until now , our hypothesis is that USP36 upregulation causes PrimPol protein deubiquitination and stabilization , which might affect chemotherapy response ."
33237263
USP36 affects PrimPol K63-linked polyubiquitination
| 1
USP36 activates PrimPol K63-linked polyubiquitination. 1 / 1
| 1
eidos
"As shown in Supplementary Figure S6C , no significant change of PrimPol K63-linked polyubiquitination could be induced by USP36 depletion ."
33237263
USP36 affects PWP2
1 |
USP36 binds PWP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects PPP6R3
1 |
PPP6R3 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects PPM1G
1 |
USP36 binds PPM1G. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects PJA1
1 |
PJA1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
26186194
USP36 affects PARP1
1 |
USP36 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects NUP85
1 |
USP36 binds NUP85. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects NUDCD1
1 |
USP36 binds NUDCD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects NSCLC
| 1
USP36 activates NSCLC. 1 / 1
| 1
reach
"Overexpression of USP36 promoted NSCLC cell proliferation and inhibited NSCLC cell apoptosis."
35133629
USP36 affects NHP2
| 1
USP36 sumoylates NHP2. 1 / 1
| 1
sparser
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs."
33852194
USP36 affects MPND
1 |
USP36 binds MPND. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects MEIS1
| 1
Modified USP36 increases the amount of MEIS1. 1 / 1
| 1
reach
"Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY)."
26206755
USP36 affects LIN28B
1 |
USP36 binds LIN28B. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects Ki67 staining
| 1
USP36 activates Ki67 staining. 1 / 1
| 1
eidos
"Depletion of USP36 significantly reduced the tumor weight , tumor volume and Ki67 staining , indicating that USP36 harbors oncogenic properties ( Figure 3C and D ) ."
34056606
USP36 affects KHK-C
| 1
USP36 decreases the amount of KHK-C. 1 / 1
| 1
reach
"Knockdown of USP36 decreased Ketohexokinase A (KHK-A) and increased KHK-C expression at both RNA and protein levels."
35133629
USP36 affects K48-ubiquitin chains
| 1
USP36 activates K48-ubiquitin chains. 1 / 1
| 1
reach
"USP36 removes K63-polyubiquitin chains from IMD and then appears to increase the addition of K48-ubiquitin chains and degradation of IMD."
20852987
USP36 affects K29-linked polyubiquitination PrimPol
| 1
USP36 inhibits K29-linked polyubiquitination PrimPol. 1 / 1
| 1
eidos
"We further examined these linkages ( Ub-K11 , Ub-K27 or Ub-K29 ) with or without USP36 knock-down , and found that USP36 depletion only increased K29-linked polyubiquitination of PrimPol ( Figure 5A , and Supplementary Figure S6B ) ."
33237263
USP36 affects JMJD6
| 1
Modified USP36 increases the amount of JMJD6. 1 / 1
| 1
reach
"Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY)."
26206755
USP36 affects IRF3
| 1
USP36 binds IRF3. 1 / 1
| 1
sparser
"We also found that USP36 interacted with IRF3 and potentiated SeV-induced activation of ISRE."
32130408
USP36 affects IR-induced DGCR8
| 1
USP36 activates IR-induced DGCR8. 1 / 1
| 1
eidos
"In both LM2 and MCF-7 cells , IR-induced upregulation of DGCR8 was reversed by shRNA-mediated knockdown of USP51 , but not by knockdown of USP36 ( Fig. 5b and Supplementary Fig. 5a ) ."
34188037
USP36 affects IFRD2
1 |
USP36 binds IFRD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects IFI16
1 |
USP36 binds IFI16. 1 / 1
1 |
biogrid
No evidence text available
25693804
USP36 affects HSPA1A
| 1
Modified USP36 increases the amount of HSPA1A. 1 / 1
| 1
reach
"Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY)."
26206755
USP36 affects HNRNPU
1 |
USP36 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP36 affects HIF1A
| 1
USP36 activates HIF1A. 1 / 1
| 1
reach
"We, therefore, analyzed the expression of Cezanne, a deubiquitinating enzyme 36 that can rescue HIF1alpha from VHL mediated degradation by cleaving ubiquitin from it."
28882872
USP36 affects H2BC21
1 |
USP36 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
No evidence text available
USP36 affects GNL2
1 |
USP36 binds GNL2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects FOXA1
1 |
USP36 binds FOXA1. 1 / 1
1 |
biogrid
No evidence text available
27926873
USP36 affects FANCI
1 |
USP36 binds FANCI. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects EXOSC10
| 1
USP36 sumoylates EXOSC10. 1 / 1
| 1
sparser
"The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing."
36912080
USP36 affects E3_Ub_ligase
| 1
sparser
"USP36 binds to one of the E3 ligases of TrkA neurotrophin receptor Nedd 4-2 and thereby regulates the association of Nedd 4-2 and TrkA ( xref )."
32133826
USP36 affects DDX41
1 |
DDX41 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects Carcinogenesis
| 1
eidos
"207 In addition to Fbw7 , other E3 ligases , such as beta-TrCP1 , CHIP and FBXO32 , can also ubiquitinate c-Myc , mediate its subsequent degradation and inhibit tumorigenesis.208-210 Moreover , the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc.211 ,212 By mass spectrometry , SUMO ligase protein inhibitor of activated STAT ( PIAS ) and Sentrin-specific protease 7 ( SENP7 ) were also found to control the SUMOylation of c-Myc at K326 and regulate its ubiquitination and degradation ( Fig. 2c ) .213 Ubiquitination regulates p53 p53 , one of the most important tumor suppressors , works in multiple cellular processes , such as cell cycle regulation , DNA repair and apoptosis ."
32140262
USP36 affects CHD7
| 1
USP36 deubiquitinates CHD7. 1 / 1
| 1
reach
"When these two long noncoding RNAs are lost, CHD7 is de-ubiquitinated by USP36 and then interacts with SOX9 to maintain a de-differentiated cellular state."
30200332
USP36 affects CHD7 protein stability
| 1
USP36 activates CHD7 protein stability. 1 / 1
| 1
eidos
"More recently , it has been shown that USP36 enhances CHD7 protein stability by direct deubiquitination , subsequently facilitating tumor progression ( 44 ) ."
33237263
USP36 affects CHD4
1 |
CHD4 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects CFTR
| 1
USP36 deubiquitinates CFTR. 1 / 1
| 1
reach
"USP36 associated with immunoprecipitated p.Phe508del-CFTR (XREF_FIG) and deubiquitinated CFTR in Rab5 + and more so Rab9 + endosomes in Talpha1 treated cells (XREF_FIG)."
28394330
USP36 affects CEP164
1 |
USP36 binds CEP164. 1 / 1
1 |
biogrid
No evidence text available
26638075
USP36 affects CDKN1A
| 1
USP36 decreases the amount of CDKN1A. 1 / 1
| 1
reach
"Consistently, knockdown of USP36 induced the expression of p21 and inhibits cell proliferation."
29274341
USP36 affects CDH1
| 1
USP36 increases the amount of CDH1. 1 / 1
| 1
reach
"As shown in Figures 3F,G, E-cadherin was obviously decreased and α-SMA was significantly enhanced in TECs under high glucose, while knockdown of USP36 could effectively reverse the expression of E-cadherin and α-SMA, which suggesting that up-regulation of USP36 may be an upstream mechanism for EMT and diabetic tubulointerstitial fibrosis."
33968925
USP36 affects CDC14B
1 |
CDC14B binds USP36. 1 / 1
1 |
biogrid
No evidence text available
27880917
USP36 affects B23
| 1
USP36 deubiquitinates B23. 1 / 1
| 1
reach
"USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation."
19208757
USP36 affects ANKRD52
1 |
USP36 binds ANKRD52. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP affects USP36
| 1
GST binds USP36 and USP. 1 / 1
| 1
sparser
"The polyubiquitinated PrimPol was incubated with purified recombinant USP domain-containing GST-USP36 1–800 (WT or CA) or control buffer followed by immunoblot with anti-Ub antibody."
33237263
UBE2I affects SUMO2
| 1
SUMO2 binds UBE2I and USP36. 1 / 1
| 1
sparser
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
Talpha1 affects USP36
| 1
Talpha1 increases the amount of USP36. 1 / 1
| 1
reach
"Talpha1 increased the expression of the mature p.Phe508del-CFTR (XREF_FIG), USP36 (XREF_FIG) and CLCA1 (XREF_FIG) in 3 out of 5 subjects with CF and concomitantly increased ion-channel activity (XREF_FIG)."
28394330
TRIM26 affects USP36
1 |
TRIM26 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM25 affects USP36
1 |
TRIM25 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
29117863
TMEM104 affects USP36
1 |
USP36 binds TMEM104. 1 / 1
1 |
biogrid
No evidence text available
19615732
TBL3 affects USP36
1 |
TBL3 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
T-2 Toxin affects USP36
1 |
T-2 Toxin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
31299295
Soman affects USP36
1 |
Soman increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
19281266
SUMO3 affects USP36
| 1
SUMO3 binds USP36. 1 / 1
| 1
reach
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
SUMO2 affects USP36
| 1
SUMO2 binds UBE2I and USP36. 1 / 1
| 1
sparser
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
STK25 affects USP36
1 |
STK25 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
SRPK2 affects USP36
1 |
SRPK2 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
26167880
SOX9 affects USP36
| 1
SOX9 binds USP36. 1 / 1
| 1
sparser
"Recent data shows that CASC15 and NBAT1 promote differentiation by interactions with SOX9 and USP36 , located on chromosome 17q that is frequently gained in high-risk neuroblastomas."
30760980
SHPRH affects USP36
1 |
SHPRH binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
RPL10 affects USP36
1 |
RPL10 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
26496610
RNAi affects USP36
| 1
RNAi inhibits USP36. 1 / 1
| 1
reach
"Although RNAi mediated knockdown of USP28, USP32 and USP36 showed that their depletion resulted in the increase of ub-K119-H2A, only USP28 depleted cells showed increased cell proliferation."
30910399
Plant Oils affects USP36
1 |
Plant Oils increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
23370395
PWP2 affects USP36
1 |
USP36 binds PWP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PPP6R3 affects USP36
1 |
PPP6R3 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
PPME1 affects USP36
| 1
USP36 binds PPME1. 1 / 1
| 1
sparser
"A previous study demonstrates that deubiquitinating enzyme USP36 binds to and regulates PME-1 through its deubiquitinating enzyme activity. xref Analysis of USP36 protein expression in clinical specimens from the Human Protein Atlas () showed that USP36 is a high expression in HCC."
32431540
PPM1G affects USP36
1 |
USP36 binds PPM1G. 1 / 1
1 |
biogrid
No evidence text available
19615732
PJA1 affects USP36
1 |
PJA1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
26186194
PCI 5002 affects USP36
1 |
PCI 5002 increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
18593933
PARP1 affects USP36
1 |
USP36 binds PARP1. 1 / 1
1 |
biogrid
No evidence text available
19615732
NUP85 affects USP36
1 |
USP36 binds NUP85. 1 / 1
1 |
biogrid
No evidence text available
19615732
NUDCD1 affects USP36
1 |
USP36 binds NUDCD1. 1 / 1
1 |
biogrid
No evidence text available
19615732
MXD1 affects USP36
| 1
MXD1 activates USP36. 1 / 1
| 1
reach
"Mechanistically, lnc-HZ01 promotes MXD1 mRNA transcription by up-regulating its transcription factor c-JUN and also enhances MXD1 protein stability by up-regulating its deubiquitin enzyme USP36."
33647641
MPND affects USP36
1 |
USP36 binds MPND. 1 / 1
1 |
biogrid
No evidence text available
19615732
MAX affects USP36
1 |
MAX decreases the amount of USP36. 1 / 1
1 |
biopax:msigdb
No evidence text available
LIN28B affects USP36
1 |
USP36 binds LIN28B. 1 / 1
1 |
biogrid
No evidence text available
19615732
KHK-A affects USP36
| 1
KHK-A inhibits USP36. 1 / 1
| 1
reach
"Overexpression of hnRNPH1/H2 reversed the downregulation of KHK-A induced inhibition of USP36."
35133629
IRF3 affects USP36
| 1
USP36 binds IRF3. 1 / 1
| 1
sparser
"We also found that USP36 interacted with IRF3 and potentiated SeV-induced activation of ISRE."
32130408
IFRD2 affects USP36
1 |
USP36 binds IFRD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
IFI16 affects USP36
1 |
USP36 binds IFI16. 1 / 1
1 |
biogrid
No evidence text available
25693804
Histone_H2B affects GST
| 1
GST binds Histone_H2B and USP36. 1 / 1
| 1
sparser
"As shown in xref , H2B bound GST-USP36 1-800 , but not GST alone."
29274341
HNRNPU affects USP36
1 |
USP36 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
26496610
H2Bub1 affects USP36
| 1
USP36 binds H2Bub1. 1 / 1
| 1
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
GST affects USP, and USP36
| 1
GST binds USP36 and USP. 1 / 1
| 1
sparser
"The polyubiquitinated PrimPol was incubated with purified recombinant USP domain-containing GST-USP36 1–800 (WT or CA) or control buffer followed by immunoblot with anti-Ub antibody."
33237263
GST affects Histone_H2B, and USP36
| 1
GST binds Histone_H2B and USP36. 1 / 1
| 1
sparser
"As shown in xref , H2B bound GST-USP36 1-800 , but not GST alone."
29274341
GNL2 affects USP36
1 |
USP36 binds GNL2. 1 / 1
1 |
biogrid
No evidence text available
19615732
FOXA1 affects USP36
1 |
USP36 binds FOXA1. 1 / 1
1 |
biogrid
No evidence text available
27926873
FANCI affects USP36
1 |
USP36 binds FANCI. 1 / 1
1 |
biogrid
No evidence text available
19615732
E3_Ub_ligase affects USP36
| 1
sparser
"USP36 binds to one of the E3 ligases of TrkA neurotrophin receptor Nedd 4-2 and thereby regulates the association of Nedd 4-2 and TrkA ( xref )."
32133826
Dietary Fats affects USP36
1 |
Dietary Fats decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
25016146
DDX41 affects USP36
1 |
DDX41 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
D-glucopyranose affects USP36
1 |
D-glucopyranose decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
22634610
CHD4 affects USP36
1 |
CHD4 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
19615732
CEP164 affects USP36
1 |
USP36 binds CEP164. 1 / 1
1 |
biogrid
No evidence text available
26638075
CDC14B affects USP36
1 |
CDC14B binds USP36. 1 / 1
1 |
biogrid
No evidence text available
27880917
C-MYC affects USP36
| 1
USP36 binds C-MYC. 1 / 1
| 1
trips
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
ATG5 affects USP36
| 1
ATG5 activates mutated USP36. 1 / 1
| 1
reach
"However, the inability of Atg5 knockdown to suppress the USP36 mutant phenotype, as well as the accumulation of both GFP-Atg8a and p62 in USP36 mutant cells, suggests a defect in autophagic flux rather than a defect in the formation of autophagosomes."
23873149
ANKRD52 affects USP36
1 |
USP36 binds ANKRD52. 1 / 1
1 |
biogrid
No evidence text available
19615732
17beta-estradiol affects USP36
1 |
17beta-estradiol increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
23019147
1-phenylpropan-2-amine decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
30779732
1-methylanthracene increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28329830
1,2-dichloroethane decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28960355
(-)-epigallocatechin 3-gallate increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
22079256