IndraLab

Statements

USP43 affects MYC
| 17 12
USP43 binds MYC.
| 5 12
MYC binds USP43. 10 / 17
| 5 12
sparser
"To test whether c-Myc directly binds to the USP43 promoter, we performed chromatin immunoprecipitation (ChIP) and qPCR."
38218970
sparser
"Collectively, these data suggest that c-Myc can directly bind to the promoter region of USP43 and activate USP43 transcription, confirming that c-Myc is a transcription factor for USP43."
38218970
sparser
"Coimmunoprecipitation assays indicated that several c-Myc mutants could interact with USP43, similar to wild-type c-Myc (Supplementary Fig. xref )."
38218970
reach
"Next, we performed a coimmunoprecipitation assay to investigate the potential interaction between USP43 and c-Myc."
38218970
sparser
"Additionally, the interaction between USP43 and c-Myc reduces the proximity of FBXW7 to c-Myc, indirectly stabilizing it."
38218970
sparser
"As shown in Fig. xref , USP43 interacted with the N-, N1-, N2-, and C1-terminus of c-Myc, while c-Myc interacted with both the N-terminus and the C-terminus of USP43."
38218970
sparser
"Moreover, endogenous USP43 interacted with c-Myc in T24 and 5637 cells (Fig. xref and Supplementary Fig. xref )."
38218970
sparser
"These findings indicate the interaction between USP43 and c-Myc."
38218970
sparser
"However, the efficacy of drugs targeting USP43 will be dependent on their ability to inhibit the deubiquitinase activity of USP43 and degrade USP43 protein or disrupt USP43-cMyc interaction."
38218970
reach
"Additionally, the interaction between USP43 and c-Myc reduces the proximity of FBXW7 to c-Myc, indirectly stabilizing it."
38218970
USP43 deubiquitinates MYC.
| 5
USP43 deubiquitinates MYC. 3 / 3
| 3
reach
"These results suggest that wild-type USP43 primarily stabilizes c-Myc by directly deubiquitinating c-Myc, while USP43 with a loss of catalytic activity still protects c-Myc to some extent by competitively binding to c-Myc with FBXW7."
38218970
reach
"Next, the type of polyubiquitin chain of c-Myc deubiquitinated by USP43 was examined, and our data indicated that USP43 catalyzed the deubiquitination of the K48 chain but not the K63 chain of c-Myc, which is associated with proteasomal pathway degradation [28] (Fig. 5H)."
38218970
reach
"Further deubiquitination assays showed that USP43 was able to deubiquitinate wild-type c-Myc but not the c-Myc mutants K148R, K289R, and K148/289R (Fig. 5J)."
38218970
USP43 deubiquitinates MYC-K148R. 1 / 1
| 1
reach
"Further deubiquitination assays showed that USP43 was able to deubiquitinate wild-type c-Myc but not the c-Myc mutants K148R, K289R, and K148/289R (Fig. 5J)."
38218970
USP43 deubiquitinates MYC-K289R. 1 / 1
| 1
reach
"Further deubiquitination assays showed that USP43 was able to deubiquitinate wild-type c-Myc but not the c-Myc mutants K148R, K289R, and K148/289R (Fig. 5J)."
38218970
USP43 activates MYC.
| 5
USP43 activates MYC. 5 / 5
| 5
reach
"This study reveals that USP43 promotes aerobic glycolysis and metastasis in BLCA by stabilizing c-Myc, thus providing a novel target for indirect inhibition of c-Myc."
38218970
reach
"To identify the lysine residue of c-Myc catalyzed by USP43, we constructed a series of c-Myc point mutant plasmids with lysine mutated to arginine."
38218970
reach
"We then constructed a double mutant of c-Myc and confirmed that K148 and K289 are indeed essential for USP43 catalysis of c-Myc (Fig. 5I and Supplementary Fig. S6F)."
38218970
reach
"USP43 antagonizes c-Myc degradation by FBXW7."
38218970
reach
"This partially explains the upregulation of USP43 in BLCA tissues, wherein amplified c-Myc increases USP43 mRNA levels."
38218970
USP43 increases the amount of MYC.
| 2
USP43 increases the amount of MYC. 2 / 2
| 2
reach
"However, knockdown of USP43 decreased the c-Myc protein level in T24 and 5637 cells (Fig. 2C), while overexpression of USP43 increased the c-Myc protein level in T24, 5637, and UM-UC-3 cells (Fig. 2D)."
38218970
reach
"Additionally, c-Myc protein levels were increased by USP43 in a dose-dependent manner (Fig. 3B)."
38218970
USP43 affects ZEB1
2 1 | 16 6
USP43 binds ZEB1.
2 | 3 6
ZEB1 binds USP43. 10 / 11
2 | 3 6
biogrid
No evidence text available
33391437
biogrid
No evidence text available
33391437
reach
"USP43 directly interacts with and deubiquitinates ZEB1, thus affecting the cell migration and EMT of CRC [88]."
38339403
reach
"Further investigation revealed a direct interaction between USP43 and ZEB1 in colorectal cell lines, wherein USP43 downregulates ZEB1 protein expression independent of its transcriptional regulation, thereby modulating the abundance of ZEB1 protein."
38613804
reach
"ZEB1 can directly interact with USP43 in cellular."
33391437
sparser
"Moreover, we have examined the potential interaction between USP43 protein and ZEB1 protein in cellular."
33391437
sparser
"In this study, Co-immunoprecipitation (Co-IP) was employed to study the potential interaction between USP43 protein and ZEB1 protein."
33391437
sparser
"Figure xref F showed that USP43 protein could interact with ZEB1 protein."
33391437
sparser
"Figure xref F and xref G had further identified the interaction between USP43 protein and ZEB1 protein."
33391437
sparser
"ZEB1 can directly interact with USP43 in cellular."
33391437
USP43 deubiquitinates ZEB1.
1 | 6
USP43 deubiquitinates ZEB1. 7 / 7
1 | 6
reach
"USP43 can enhance CRC cell growth by inducing the deubiquitination of Zinc finger E-box-binding homeobox 1 (ZEB1) protein, which is closely associated with tumor cell proliferation, invasion, migration and expression of EMT-related biomarkers."
37251574
reach
"USP43 promoted cell proliferation, migration and invasion of colorectal cancer, and reduce the sensitivity of chemotherapy through deubiquitinating ZEB1 [12]."
38087046
ubibrowser
"Meanwhile, <span class="match term0">USP43</span> can deubiquitinate and stabilize the <span class="match term1">ZEB1</span> protein, which plays an important role in the function of colorectal cancer."
33391437
reach
"In patients with osteosarcoma and lung metastasis, USP43 deubiquitinates ZEB1 and maintains its transcription [65], resulting in increased invasion of osteosarcoma cells via inducing EMT [88, 89]."
38613804
reach
"Meanwhile, USP43 can deubiquitinate and stabilize the ZEB1 protein, which plays an important role in the function of colorectal cancer."
33391437
reach
"USP43 could promote cell proliferation, invasion, and migration in colorectal cancer by regulating ZEB1 ubiquitylation degradation."
33391437
reach
"USP43 directly interacts with and deubiquitinates ZEB1, thus affecting the cell migration and EMT of CRC [88]."
38339403
USP43 activates ZEB1.
| 5
USP43 activates ZEB1. 5 / 5
| 5
reach
"The results suggested that USP43 knockdown treated SW480 cells could significantly promote the degradation of the remaining ZEB1 protein in cells compared to that normal SW480 cells (P < 0.01)."
33391437
reach
"Meanwhile, USP43 overexpression treated DLD1 cells could significantly decrease the degradation of the remaining ZEB1 protein in cells compared to that normal DLD1 cells (P < 0.01)."
33391437
reach
"Figure XREF_FIG K and 5L suggested that USP43 overexpression in DLD1 cells could significantly promote the remaining ZEB1 protein in cells compared to that normal DLD1 cells (P < 0.01)."
33391437
reach
"Meanwhile, USP43 knockdown treated SW480 cells could significantly decrease the remaining ZEB1 protein in cells compared to that normal SW480 cells (P < 0.01)."
33391437
reach
"USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer."
33391437
USP43 decreases the amount of ZEB1.
| 2
USP43 decreases the amount of ZEB1. 2 / 2
| 2
reach
"Further investigation revealed a direct interaction between USP43 and ZEB1 in colorectal cell lines, wherein USP43 downregulates ZEB1 protein expression independent of its transcriptional regulation, thereby modulating the abundance of ZEB1 protein."
38613804
reach
"Moreover, USP43 can reduce ZEB1 protein expression without affecting its transcription."
33391437
MYC affects USP43
| 10 13
MYC binds USP43.
| 5 12
MYC binds USP43. 10 / 17
| 5 12
sparser
"To test whether c-Myc directly binds to the USP43 promoter, we performed chromatin immunoprecipitation (ChIP) and qPCR."
38218970
sparser
"Collectively, these data suggest that c-Myc can directly bind to the promoter region of USP43 and activate USP43 transcription, confirming that c-Myc is a transcription factor for USP43."
38218970
sparser
"Coimmunoprecipitation assays indicated that several c-Myc mutants could interact with USP43, similar to wild-type c-Myc (Supplementary Fig. xref )."
38218970
reach
"Next, we performed a coimmunoprecipitation assay to investigate the potential interaction between USP43 and c-Myc."
38218970
sparser
"Additionally, the interaction between USP43 and c-Myc reduces the proximity of FBXW7 to c-Myc, indirectly stabilizing it."
38218970
sparser
"As shown in Fig. xref , USP43 interacted with the N-, N1-, N2-, and C1-terminus of c-Myc, while c-Myc interacted with both the N-terminus and the C-terminus of USP43."
38218970
sparser
"Moreover, endogenous USP43 interacted with c-Myc in T24 and 5637 cells (Fig. xref and Supplementary Fig. xref )."
38218970
sparser
"These findings indicate the interaction between USP43 and c-Myc."
38218970
sparser
"However, the efficacy of drugs targeting USP43 will be dependent on their ability to inhibit the deubiquitinase activity of USP43 and degrade USP43 protein or disrupt USP43-cMyc interaction."
38218970
reach
"Additionally, the interaction between USP43 and c-Myc reduces the proximity of FBXW7 to c-Myc, indirectly stabilizing it."
38218970
MYC increases the amount of USP43.
| 3
MYC increases the amount of USP43. 3 / 3
| 3
reach
"Stable c-Myc can function as a transcription factor to activate USP43 transcription."
38218970
reach
"C-Myc oncoprotein promotes the transcription of USP43 and regulates the transcription of at least 15% of the entire genome as a transcription factor."
38613804
reach
"Moreover, in 293 T cells, exogenous expression of c-Myc increased the mRNA level of USP43 (Fig. 7F)."
38218970
MYC activates USP43.
| 2 1
MYC activates USP43. 3 / 3
| 2 1
reach
"The dual-luciferase reporter assay revealed that exogenous c-Myc significantly increased the activity of the USP43 promoter."
38218970
sparser
"Furthermore, MYC transcriptionally activates POLD1 and USP43, forming reciprocal positive feedback loops (POLD1-MYC and USP43-MYC) that promote BLCA progression [ xref , xref ]."
39980052
reach
"Furthermore, MYC transcriptionally activates POLD1 and USP43, forming reciprocal positive feedback loops (POLD1-MYC and USP43-MYC) that promote BLCA progression [42, 43]."
39980052
USP43 activates cell population proliferation. 10 / 21
| 1 20
reach
"For instance, USP43 promoted cell proliferation, migration and invasion of colorectal cancer [12]."
38087046
reach
"USP43 could promote the proliferation, migration, and invasion of colorectal cancer."
33391437
reach
"USP43 promotes proliferation of colorectal cancer cells in vitro."
33391437
reach
"For cell proliferation analysis, USP43 knockdown in SW480 cells could significantly reduce cell proliferation compared with those in normal SW480 cells on days 2, 3, 4, 5 (P < 0.01)."
33391437
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
reach
"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
38087046
eidos
"USP43 could promote cell proliferation , invasion , and migration in colorectal cancer by regulating ZEB1 ubiquitylation degradation ."
33391437
reach
"USP43 promoted cell proliferation, migration, invasion and chemoresistance of EOC."
38087046
reach
"Overexpression of USP43 significantly increased cell proliferation (Fig. 3D and F)."
38087046
reach
"USP43 overexpression promoted PANC-1 cell proliferation (P = 0.0018), but USP43 knockdown decreased PANC02 cell proliferation (P < 0.001)."
37050932
USP43 inhibits cell population proliferation. 1 / 1
| 1
reach
"Conversely, USP43 overexpression consistently exhibits the opposite effect and represses cell proliferation and tumor growth, providing further support for a tumor suppressive role of USP43 in breast [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34953650
USP43 affects NPPA
| 17
NPPA binds USP43. 10 / 17
| 17
sparser
"USP monograph (USP43–NF38) also touched upon the process of enrichment of deamidated variant >5% by acidic treatment."
33957255
sparser
"The criteria of benzoin from Chinese pharmacopoeia (ChP 2020), USA pharmacopoeia (USP43-NF38), European pharmacopoeia (EP10.0), Japanese pharmacopoeia (JP18) and Indian pharmacopoeia (IP2018) are summarized in xref , in which content determination, ethanol-insoluble matter, acid-insoluble ash, loss on drying, total ash and presence of dammar gum require detailed analysis [ xref , xref , xref , xref , xref ]."
37653893
sparser
"At present, there is no quality control for the polymerized impurities in United States Pharmacopoeia (USP43-NF38) [7] containing mezlocillin sodium, and Japanese Pharmacopoeia (JP17) [8] and Korean P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35026591
sparser
"Monographs of all three natural CDs and two of their derivatives can be found in the United States Pharmacopoeia- National Formulary (USP43–NF38) and the European Pharmacopoeia (Pharmacopoeia Europaea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33069709
sparser
"In addition, the limit of the number of micro-particles ≥10 and 25 μm in 100-mL filling-volume injections is consistent with those indicated in the pharmacopoeias of all countries, such as USP43–NF38, European Pharmacopoeia 10.0 and Chinese Pharmacopoeia 2020, with limits set as ≤12 and 2 particles/mL."
39170535
sparser
"A standard of upper loss on drying value of 7% is stated in the USP monograph (USP43-NF38)."
34973783
sparser
"USP43-NF38, VP5, and KP12 provided small numbers of stipulations for mineral medicines."
37202592
sparser
"Three syrup bases were used: a sugar-free vehicle for oral solution (according to USP43-NF38), a vehicle with glucose and hydroxypropyl cellulose (according to the DAC/NRF2018) and a commercially available SyrSpend Alka base."
36986577
sparser
"BP6, IP2018, Korean Pharmacopoeia 12th edition (KP12) and United States Pharmacopoeia and National Formulary 2020 (USP43-NF38) provided stipulations of impurities for most of the animal/botanical medicines (95%, 80%, 95%, and 69%, respectively)."
37202592
sparser
"In The United States Pharmacopeia (USP43-NF38) [United States Pharmacopeia Convention, Inc.: Rockville, MD, USA, 2023], the drug is more soluble, and in fact all of the samples can release the dose of the drug within an hour."
39683769
USP43 affects Neoplasm Invasiveness
| 1 15
USP43 activates Neoplasm Invasiveness.
| 1 14
USP43 activates Neoplasm Invasiveness. 10 / 14
| 1 13
reach
"USP43 potentially regulates cancer invasion by modulating EMT-associated transcription factors, such as ZEB1 or SNAIL, in breast cancer, colorectal cancer, and osteosarcoma."
38613804
reach
"In breast cancer, USP43 promotes invasion and metastasis through invadopodia formation."
38613804
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
reach
"USP43 knockdown in SW480 cells could significantly inhibit cell migration and invasion compared to that in the normal SW480 cells (P < 0.01)."
33391437
reach
"However, USP43 overexpression in DLD1 cells could promote cell migration and invasion compared to that in the normal DLD1 cells (P < 0.01)."
33391437
reach
"For instance, USP43 promoted cell proliferation, migration and invasion of colorectal cancer [12]."
38087046
reach
"Meanwhile, ZEB1overexpression could effectively reverse the changes in invasion caused by USP43 overexpression in SW480 cells (P < 0.01)."
33391437
reach
"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
38087046
reach
"Furthermore, USP43 was highly expressed in colorectal cancer (CRC) and increased CRC cell proliferation, invasion, and migration [23]."
37050932
reach
"The study delves into the tumor-promoting impact in EOC, showing that USP43 enhances the proliferation, invasion, and migration of EOC, and facilitates EOC cells to enter the cell cycle’s proliferation phase.Cisplatin is a primary chemotherapeutic treatment for EOC."
38613804
USP43 activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"For instance, USP43 modulates the infiltration of immune cells surrounding pancreatic ductal adenocarcinoma, thereby affecting patient prognosis [7]."
39979972
USP43 bound to NuRD inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"Therefore, it has been established that the USP43/NuRD complex inhibits the growth, invasion, and metastasis of breast cancer cells; thus, USP43 may serve as a suppressor of breast cancer."
38613804
USP43 affects cisplatin
| 13
USP43 inhibits cisplatin.
| 12
USP43 inhibits cisplatin. 10 / 12
| 12
reach
"Taken together, our results suggested that USP43 impaired the sensitivity of EOC cells to cisplatin by activating the Wnt/β-catenin signaling pathway through HDAC2."
38087046
reach
"Notably, knockdown of USP43 enhanced cisplatin-induced apoptosis (Fig. 6C), while USP43 overexpression diminished the effect of cisplatin (Fig. 6D)."
38087046
reach
"In EOC, USP43 promotes the proliferation and impairs cisplatin sensitivity."
38613804
reach
"In the current study, we demonstrated that USP43 facilitated the malignant behaviors, and decreased the sensitivity of cisplatin to EOC cells."
38087046
reach
"These data suggested that USP43 reduced cisplatin sensitivity in EOC cells through suppressing DNA damage."
38087046
reach
"USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/beta-catenin signaling pathway."
38087046
reach
"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
38087046
reach
"To confirm whether HDAC2 is involved in the USP43-induced reduction of cisplatin sensitivity in EOC cells, USP43 over-expressed cells were transfected with si-HDAC2 or si-NC."
38087046
reach
"The overexpression of USP43 attenuated the inhibition of cisplatin on EOC cells, while HDAC2 silencing reversed the result (Fig. 10C)."
38087046
reach
"USP43 promotes the proliferation of epithelial ovarian cancer (EOC) and impairs its cisplatin sensitivity."
38613804
USP43 activates cisplatin.
| 1
USP43 activates cisplatin. 1 / 1
| 1
reach
"These results showed that USP43 promoted the sensitivity of EOC cells to cisplatin via HDAC2."
38087046
USP43 affects Neoplasm Metastasis
| 12
USP43 activates Neoplasm Metastasis.
| 9
USP43 activates Neoplasm Metastasis. 9 / 9
| 9
reach
"This study reveals that USP43 promotes aerobic glycolysis and metastasis in BLCA by stabilizing c-Myc, thus providing a novel target for indirect inhibition of c-Myc."
38218970
reach
"In addition, studies have shown that USP43 mediates metastasis in breast and colon cancer [12, 59], but it has not been reported in ovarian cancer metastasis or recurrence, and it will be a direction for our investigation in the future.In conclusion, USP43 impaired cisplatin sensitivity by activating the Wnt/β-catenin signaling pathway via HDAC2 deubiquitylation, thereby promoting EOC progression."
38087046
reach
"In breast cancer, USP43 promotes invasion and metastasis through invadopodia formation."
38613804
reach
"In BLCA, USP43 promotes glycolysis and metastasis."
38613804
reach
"In vivo, USP43 knockdown led to reduced tumor growth and lung metastasis."
39922114
reach
"Overall, these findings suggest that USP43 promotes BLCA cell metastasis."
38218970
reach
"USP43 promotes glycolysis and metastasis in bladder cancer (BLCA)."
38613804
reach
"Moreover, USP43 may stimulate the metastasis of BLCA."
38613804
reach
"To further investigate if USP43 mediated the function of Ca 2.2 in metastasis in vivo, we transplanted luciferase-tagged MDA-MB-436 cells stably expressing Ca 2.2 shRNA and USP43 cDNA constructs into mice."
36137995
USP43 inhibits Neoplasm Metastasis.
| 3
reach
"We show that USP43 strongly suppresses the growth and metastasis of breast cancer in vivo."
30135474
reach
"Meanwhile, previous study indicated that USP43 could remarkably inhibit the growth and metastasis of breast cancer though affecting EGFR/PI3K/AKT XREF_BIBR."
33391437
USP43 bound to NuRD inhibits Neoplasm Metastasis. 1 / 1
| 1
reach
"Therefore, it has been established that the USP43/NuRD complex inhibits the growth, invasion, and metastasis of breast cancer cells; thus, USP43 may serve as a suppressor of breast cancer."
38613804
ZEB1 affects USP43
2 | 3 6
ZEB1 binds USP43. 10 / 11
2 | 3 6
biogrid
No evidence text available
33391437
biogrid
No evidence text available
33391437
reach
"USP43 directly interacts with and deubiquitinates ZEB1, thus affecting the cell migration and EMT of CRC [88]."
38339403
reach
"Further investigation revealed a direct interaction between USP43 and ZEB1 in colorectal cell lines, wherein USP43 downregulates ZEB1 protein expression independent of its transcriptional regulation, thereby modulating the abundance of ZEB1 protein."
38613804
reach
"ZEB1 can directly interact with USP43 in cellular."
33391437
sparser
"Moreover, we have examined the potential interaction between USP43 protein and ZEB1 protein in cellular."
33391437
sparser
"In this study, Co-immunoprecipitation (Co-IP) was employed to study the potential interaction between USP43 protein and ZEB1 protein."
33391437
sparser
"Figure xref F showed that USP43 protein could interact with ZEB1 protein."
33391437
sparser
"Figure xref F and xref G had further identified the interaction between USP43 protein and ZEB1 protein."
33391437
sparser
"ZEB1 can directly interact with USP43 in cellular."
33391437
P14_3_3 affects USP43
| 10
USP43 binds p14_3_3. 10 / 10
| 10
sparser
"Moreover, the interaction between 14-3-3 and USP43 could be replicated using Culyculin A as a phosphatase inhibitor (Resjö et al, xref ), and conversely, prevented by Lambda PP (Fig.  xref )."
39009674
sparser
"We examined if the USP43 and 14-3-3 interaction was important for the recruitment of HIF-1α, and observed that USP43 loss decreased levels of HIF-1α associated with endogenous 14-3-3 (Fig.  xref )."
39009674
sparser
"However, the association of USP43 with 14-3-3 was important for regulating HIF-1 signalling, as pan-siRNA-mediated depletion of 14-3-3 (targeting 6 of 7 isoforms) (Fig.  xref ) reduced activation of the fluorescent HIF reporter and endogenous CA9, without affecting HIF-1α protein and mRNA levels (Figs.  xref and  xref )."
39009674
sparser
"Mechanistically, USP43 associates with 14-3-3 proteins in a hypoxia and phosphorylation dependent manner to increase the nuclear pool of HIF-1."
39009674
sparser
"It is, therefore, plausible that USP43 interacts with different 14-3-3 proteins depending on the context."
39009674
sparser
"In addition, as 14-3-3 proteins interact with phosphorylated ligands (Fu et al, xref ), phosphorylation is likely to provide the recruitment signal, in keeping with our observation that Ser phosphorylated USP43 bound 14-3-3 proteins."
39009674
sparser
"USP43 associates with 14-3-3 proteins to regulate HIF-1 signalling."
39009674
sparser
"We confirmed that USP43 binds 14-3-3 proteins, using overexpressed HA-USP43 and endogenous USP43 in HeLa cells (Fig.  xref ), consistent with the DUB mass spectrometry interactome (Sowa et al, xref )."
39009674
sparser
"Moreover, we found that 14-3-3 proteins bound USP43 more strongly in 1% oxygen (Fig.  xref )."
39009674
sparser
"The association of USP43 with 14-3-3 to facilitate a HIF-1-specific response provides a further layer of complexity in how HIF signalling is controlled and helps explain how differential transcription programmes are initiated."
39009674
USP43 is modified
5 | 5
USP43 is phosphorylated.
5 | 2
USP43 is phosphorylated. 2 / 2
| 2
sparser
"Consistently, we showed that USP43 is phosphorylated using Lambda protein phosphatase (Lambda PP) and a gel shift assay (Fig.  xref )."
39009674
sparser
"In addition, as 14-3-3 proteins interact with phosphorylated ligands (Fu et al, xref ), phosphorylation is likely to provide the recruitment signal, in keeping with our observation that Ser phosphorylated USP43 bound 14-3-3 proteins."
39009674
USP43 is phosphorylated on S1041. 1 / 1
1 |
hprd
No evidence text available
18669648
USP43 is phosphorylated on S851. 1 / 1
1 |
hprd
No evidence text available
18669648
USP43 is phosphorylated on Y835. 1 / 1
1 |
hprd
No evidence text available
17389395
USP43 is phosphorylated on S848. 1 / 1
1 |
hprd
No evidence text available
18669648
USP43 is phosphorylated on S846. 1 / 1
1 |
hprd
No evidence text available
18669648
USP43 is ubiquitinated.
| 2
USP43 is ubiquitinated. 2 / 2
| 2
sparser
"The proteins most affected by all three CGs were all significantly upregulated and included glycolytic enzyme GOT2, glutamate dehydrogenase GLUD1, hepatoma‐derived growth factor‐related protein HDGFL2, LIM and SH3 domain protein LASP1, cytochrome c CYCS, and de‐ubiquitinating enzyme USP43."
39350574
sparser
"Moreover, we have investigated the potential relationships between USP43 ubiquitination and ZEB1 in USP43 overexpression DLD1 cells."
33391437
USP43 is methylated.
| 1
USP43 is methylated. 1 / 1
| 1
sparser
"Based on these findings, the Disease Meth web tool () was used to analyze the difference of USP43 methylation level in OV and normal tissues."
38087046
USP43 affects HDAC2
2 | 6 1
USP43 binds HDAC2.
2 | 1 1
USP43 binds HDAC2. 4 / 4
2 | 1 1
biogrid
No evidence text available
30135474
reach
"The interaction between USP43 and HDAC2 was confirmed by Co-IP assay (Fig. 9C)."
38087046
sparser
"The interaction between USP43 and HDAC2 was confirmed by Co-IP assay (Fig.  xref C)."
38087046
biogrid
No evidence text available
30135474
USP43 inhibits HDAC2.
| 2
USP43 inhibits HDAC2. 2 / 2
| 2
reach
"Mechanistically, USP43 inhibited HDAC2 degradation and enhanced HDAC2 protein stability through its deubiquitylation function."
38087046
reach
"HDAC2 silencing elevated apoptosis rate induced by overexpression of USP43 (Fig. 10D)."
38087046
USP43 activates HDAC2.
| 2
USP43 activates HDAC2. 2 / 2
| 2
reach
"Mechanistically, USP43 inhibited HDAC2 degradation and enhanced HDAC2 protein stability through its deubiquitylation function."
38087046
reach
"These results demonstrated that USP43 diminished HDAC2 degradation via deubiquitylation."
38087046
USP43 increases the amount of HDAC2.
| 1
USP43 increases the amount of HDAC2. 1 / 1
| 1
reach
"With cycloheximide treatment, we observed that USP43 knockdown decreased the expression of HDAC2 in HEY cells, indicating that downregulation of USP43 reduced HDAC2 stability (Fig. 9D)."
38087046
USP43 affects CTTN
| 7 2
USP43 increases the amount of CTTN.
| 3
USP43 increases the amount of CTTN. 3 / 3
| 3
reach
"Conversely, over-expression of USP43 increased cortactin protein expression without affecting its expression at the transcriptional level (Fig. 5D, E)."
36137995
reach
"These results indicated that USP43 mediated the functions of Ca 2.2 in cortactin expression, invadopodia formation, ECM degradation, and metastasis."
36137995
reach
"We then transfected the cDNAs of these six DUBs into MDA-MB-231 cells, and immunoblotting showed that only USP43 increased cortactin expression (Supplementary Fig. 9A)."
36137995
USP43 decreases the amount of CTTN.
| 2
USP43 decreases the amount of CTTN. 2 / 2
| 2
reach
"Knock-down of USP43 in MDA-MB-231 cells decreased the expression of cortactin at the protein level (Fig. 5B) but did not affect its transcript (Fig. 5C)."
36137995
reach
"The addition of MG132 successfully rescued the decrease of cortactin expression caused by USP43 knock-down (Fig. 5F), while the addition of CHX resulted in more unstable cortactin protein in USP43 knock-down cells (Fig. 5G)."
36137995
USP43 binds CTTN.
| 2
USP43 binds CTTN. 2 / 2
| 2
sparser
"We first determined whether USP43 interacted with cortactin."
36137995
sparser
"Immunoprecipitation showed that USP43 interacted with cortactin in MDA-MB-231 cells (Fig. xref )."
36137995
USP43 ubiquitinates CTTN.
| 1
USP43 leads to the ubiquitination of CTTN. 1 / 1
| 1
reach
"We next investigated whether USP43 was able to modulate cortactin ubiquitination in MDA-MB-231 cells."
36137995
USP43 activates CTTN.
| 1
USP43 activates CTTN. 1 / 1
| 1
reach
"Together, these results suggested that USP43 directly regulates cortactin stability through deubiquitination."
36137995
NFATC1 affects USP43
| 8 1
NFATC1 increases the amount of USP43.
| 4
NFATC1 increases the amount of USP43. 3 / 3
| 3
reach
"We found that depletion of NFAT2 and NFAT3 could significantly reduced USP43 mRNA expression (Fig. 7D, Supplementary Fig. 11)."
36137995
reach
"These data suggested that NFAT2 directly regulates USP43 transcription."
36137995
reach
"(p29) N-type CaV2.2 promotes metastasis by modulating the activation of calcium-dependent phosphatase/nuclear factor of activated NFAT2 signaling pathways, which upregulates USP43 expression by dephos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38670255
Unphosphorylated NFATC1 increases the amount of USP43. 1 / 1
| 1
reach
"(p29) N-type CaV2.2 promotes metastasis by modulating the activation of calcium-dependent phosphatase/nuclear factor of activated NFAT2 signaling pathways, which upregulates USP43 expression by dephos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38670255
NFATC1 activates USP43.
| 4
NFATC1 activates USP43. 4 / 4
| 4
reach
"To verify whether USP43 is directly regulated by NFAT2, we cloned USP43 promoter (−213~−1847bp) into pGL3-basic vector and performed dual luciferase reporter assay."
36137995
reach
"USP43 is directly regulated by NFAT2."
36137995
reach
"Expression of NFAT2 increased USP43 mRNA and protein expression (Fig. 7F, G)."
36137995
reach
"These data indicated that NFAT2 mediates the regulation of USP43 by Ca 2.2."
36137995
NFATC1 binds USP43.
| 1
USP43 binds NFATC1. 1 / 1
| 1
sparser
"We used Chromatin Immunoprecipitation (ChIP) analysis to further determined the direct interactions of NFAT2 with USP43 promoter in MDA-MB-231 cells, ChIP analysis indicated the significant enrichment of USP43 promoter as well as BMI1 promoter which is a well-established direct target gene of NFAT2 [ xref ] and served as a control in NFAT2 immunoprecipitation (Fig. xref , Supplementary Fig. xref )."
36137995
Calcium(2+) affects USP43
| 7
Calcium(2+) increases the amount of USP43.
| 4
Calcium(2+) increases the amount of USP43. 4 / 4
| 4
reach
"Ca v 2.2 by activating calcineurin/NFAT2 dephosphorylation modulates the deubiquinating enzyme USP43 expression that promotes invadopodia formation by stabilizing cortactin, which lead to metastasis.A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37247443
reach
"Interestingly, Ca v 2.2 upregulates USP43 expression through NFAT2 dephosphorylation and nuclear localization."
36137995
reach
"We then investigated the regulation of USP43 by Ca 2.2 and found that knock-down of Ca 2.2 decreased USP43 expression whereas over-expression of Ca 2.2 increased USP43 expression transcriptionally and at the protein level (Fig. 7A–C)."
36137995
reach
"NFAT2 knock-down abolished the up-regulation of USP43 levels by Ca 2.2 (Fig. 8A, B)."
36137995
Calcium(2+) activates USP43.
| 2
Calcium(2+) activates USP43. 2 / 2
| 2
reach
"These data indicated that NFAT2 mediates the regulation of USP43 by Ca 2.2."
36137995
reach
"The involvement of USP43 in breast cancer has been documented in two previous studies suggesting that Ca 2.2 upregulates USP43 to promote tumorigenesis in breast cancer [36]."
38613804
Calcium(2+) decreases the amount of USP43.
| 1
Calcium(2+) decreases the amount of USP43. 1 / 1
| 1
reach
"We then investigated the regulation of USP43 by Ca 2.2 and found that knock-down of Ca 2.2 decreased USP43 expression whereas over-expression of Ca 2.2 increased USP43 expression transcriptionally and at the protein level (Fig. 7A–C)."
36137995
YWHAB affects USP43
6 |
USP43 binds YWHAB. 6 / 6
6 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
36931259
biogrid
No evidence text available
33961781
biogrid
No evidence text available
30135474
biogrid
No evidence text available
19615732
biogrid
No evidence text available
30135474
Bisphenol A affects USP43
5 |
Bisphenol A decreases the amount of USP43.
3 |
Bisphenol A decreases the amount of USP43. 3 / 3
3 |
ctd
No evidence text available
25181051
ctd
No evidence text available
32528016
ctd
No evidence text available
30816183
Bisphenol A methylates USP43.
1 |
Bisphenol A methylates USP43. 1 / 1
1 |
ctd
No evidence text available
28505145
Bisphenol A demethylates USP43.
1 |
Bisphenol A demethylates USP43. 1 / 1
1 |
ctd
No evidence text available
31601247
YWHAE affects USP43
5 |
USP43 binds YWHAE. 5 / 5
5 |
biogrid
No evidence text available
36931259
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
19615732
biogrid
No evidence text available
30135474
USP43 affects apoptotic process
| 5
USP43 inhibits apoptotic process. 5 / 5
| 5
reach
"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
38087046
reach
"HDAC2 silencing elevated apoptosis rate induced by overexpression of USP43 (Fig. 10D)."
38087046
reach
"Our results demonstrated that USP43 inhibition of apoptosis affected the sensitivity of EOC to cisplatin.High-level expression of HDAC2 promotes cancer progression through various signal pathways, including breast cancer [38, 39], non-small cell lung cancer [16], liver cancer [40]."
38087046
reach
"USP43 suppressed DNA damage and apoptosis, thereby reducing the sensitivity of EOC cells to cisplatin."
38613804
reach
"USP43 overexpression diminished cell apoptosis induced by cisplatin, and ICG-001 treatment restored this effect (Fig. 10L)."
38087046
USP43 affects YWHAE
5 |
USP43 binds YWHAE. 5 / 5
5 |
biogrid
No evidence text available
36931259
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
19615732
biogrid
No evidence text available
30135474
USP43 affects Wnt/β-catenin
| 5
USP43 activates Wnt/β-catenin.
| 4
USP43 activates Wnt/β-catenin. 4 / 4
| 4
reach
"Notably, knockdown of HDAC2 diminished the activation of Wnt/β-catenin signaling pathway caused by upregulation of USP43 (Fig. 10J, K)."
38087046
reach
"These results indicated that USP43 activated Wnt/β-catenin signaling pathway through HDAC2.To further determine whether USP43 regulates the sensitivity of EOC cells to cisplatin via the Wnt/β-catenin signaling pathway, EOC cells were co-treated with Wnt/β-catenin signaling pathway inhibitor ICG-001 and cisplatin."
38087046
reach
"Mechanically, USP43 activated the Wnt/β-catenin signaling pathway through inhibiting ubiquitin-mediated degradation of HDAC2 to induce EOC cell chemoresistance.USP43 functions as a tumor promoter in multiple cancers."
38087046
reach
"Further research found that USP43 induced activation of the Wnt/β-catenin signaling pathway by regulating HDAC2."
38087046
USP43 inhibits Wnt/β-catenin.
| 1
USP43 inhibits Wnt/β-catenin. 1 / 1
| 1
reach
"Taken together, our results suggested that USP43 impaired the sensitivity of EOC cells to cisplatin by activating the Wnt/β-catenin signaling pathway through HDAC2."
38087046
USP43 affects Neoplasms
| 5
USP43 activates Neoplasms.
| 4
USP43 activates Neoplasms. 4 / 4
| 4
reach
"In vivo xenograft tumors, silencing USP43 slowed tumor growth and enhanced cisplatin sensitivity."
38087046
reach
"Knockdown of USP43 inhibited tumor growth and enhanced cisplatin sensitivity of EOCin vivo.."
38087046
reach
"Thus, we concluded that knockdown of USP43 inhibited tumor growth and enhanced cisplatin sensitivity of EOC in vivo."
38087046
reach
"These findings suggest that the two functions of USP43 operate in coordination to maintain c-Myc as an oncoprotein and promote tumor progression (Fig. 8)."
38218970
USP43 inhibits Neoplasms.
| 1
USP43 inhibits Neoplasms. 1 / 1
| 1
reach
"Conversely, USP43 overexpression consistently exhibits the opposite effect and represses cell proliferation and tumor growth, providing further support for a tumor suppressive role of USP43 in breast [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34953650
USP43 affects HIF1A
| 5
USP43 binds HIF1A. 5 / 5
| 5
sparser
"Importantly, the interaction between HIF-1α and USP43 did not prevent the formation of a HIF heterodimer, as HIF1-α and HIF1β still associated in USP43 null HeLa cells (Fig.  xref ), and neither USP43 depletion nor overexpression altered HIF-1α degradation kinetics using cycloheximide chase assay of HIF-1α degradation (Fig.  xref )."
39009674
sparser
"Instead, we show that USP43 associates with HIF-1α and promotes the nuclear accumulation of HIF-1 and the chromatin binding of the transcriptional complex to specific HIF-1 target genes."
39009674
sparser
"To understand how USP43 may facilitate a HIF-1 transcriptional response, we examined if USP43 associated with HIF-1α in hypoxia by incubating HeLa cells in 21 or 1% oxygen for 6 h and immunoprecipitating endogenous USP43 or HIF-1α."
39009674
sparser
"USP43 bound to HIF-1α in hypoxia, and depletion of HIF1β did not prevent the association between endogenous USP43 and HIF-1α (Figs.  xref and  xref )."
39009674
sparser
"The association of USP43 with HIF-1α was also observed in other cell lines (A549 and MCF7 cells) (Fig.  xref )."
39009674
Valproic acid affects USP43
4 |
Valproic acid increases the amount of USP43. 4 / 4
4 |
ctd
No evidence text available
26272509
ctd
No evidence text available
24383497
ctd
No evidence text available
23179753
ctd
No evidence text available
27188386
USP43 activates signal transduction.
| 3
reach
"These results indicated that USP43 activated Wnt/β-catenin signaling pathway through HDAC2.To further determine whether USP43 regulates the sensitivity of EOC cells to cisplatin via the Wnt/β-catenin signaling pathway, EOC cells were co-treated with Wnt/β-catenin signaling pathway inhibitor ICG-001 and cisplatin."
38087046
reach
"Notably, knockdown of HDAC2 diminished the activation of Wnt/β-catenin signaling pathway caused by upregulation of USP43 (Fig. 10J, K)."
38087046
reach
"Mechanically, USP43 activated the Wnt/β-catenin signaling pathway through inhibiting ubiquitin-mediated degradation of HDAC2 to induce EOC cell chemoresistance.USP43 functions as a tumor promoter in multiple cancers."
38087046
USP43 inhibits signal transduction.
| 1
USP43 inhibits signal transduction. 1 / 1
| 1
reach
"Taken together, our results suggested that USP43 impaired the sensitivity of EOC cells to cisplatin by activating the Wnt/β-catenin signaling pathway through HDAC2."
38087046
USP43 activates glycolytic process. 4 / 4
| 4
reach
"In BLCA, USP43 promotes glycolysis and metastasis."
38613804
reach
"This study reveals that USP43 promotes aerobic glycolysis and metastasis in BLCA by stabilizing c-Myc, thus providing a novel target for indirect inhibition of c-Myc."
38218970
reach
"USP43 promotes glycolysis and metastasis in bladder cancer (BLCA)."
38613804
reach
"These results demonstrate that USP43 positively regulates glycolysis in BLCA and c-Myc transcriptional activity."
38218970
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
reach
"Silencing of USP43 reduced cell proliferation, migration, invasion, and the epithelial-mesenchymal transition (EMT) process."
39922114
reach
"In addition, USP43 could promote tumorigenesis by regulating cell cycle and EMT process in breast cancer XREF_BIBR."
33391437
reach
"We next detected whether USP43 regulated EMT, our results demonstrated that USP43 promoted EMT through regulated snail, thereby facilitated breast cancer cells metastasis."
31966446
USP43 affects VIM
| 4
USP43 increases the amount of VIM. 2 / 2
| 2
reach
"Meanwhile, USP43 knockdown in SW480 cells could inhibit and promote the protein expressions of N-cadherin and Vimentin and protein expressions of N-cadherin, respectively."
33391437
reach
"USP43 knockdown in SW480 cells could effectively inhibit protein expressions of N-cadherin and Vimentin (P < 0.01)."
33391437
Modified USP43 increases the amount of VIM. 2 / 2
| 2
reach
"Therefore, USP43 overexpression in DLD1 cells could promote and inhibit the protein expressions of N-cadherin and Vimentin and protein expressions of N-cadherin, respectively."
33391437
reach
"Moreover, USP43 overexpression in DLD1 cells could effectively increase protein expressions of N-cadherin and Vimentin (P < 0.01)."
33391437
USP43 affects TAFAZZIN
| 3 1
USP43 binds TAFAZZIN.
| 2 1
USP43 binds TAFAZZIN. 3 / 3
| 2 1
sparser
"Immunofluorescence staining and co-immunoprecipitation (Co-IP) assays were used to explore the interaction between USP43 and TAZ."
39922114
reach
"Immunofluorescence staining and co-immunoprecipitation (Co-IP) assays were used to explore the interaction between USP43 and TAZ."
39922114
reach
"Co-IP and ubiquitination assays revealed that USP43 interacted with and stabilized TAZ by inhibiting TAZ ubiquitination."
39922114
USP43 activates TAFAZZIN.
| 1
USP43 activates TAFAZZIN. 1 / 1
| 1
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
USP43 affects NuRD
| 4
USP43 binds NuRD. 4 / 4
| 4
reach
"The USP43/NuRD complex inhibits the activity of EGFR and AKT, while the EGFR/PI3K/AKT signaling pathway regulates the behavior of USP43."
38613804
reach
"Therefore, it has been established that the USP43/NuRD complex inhibits the growth, invasion, and metastasis of breast cancer cells; thus, USP43 may serve as a suppressor of breast cancer."
38613804
reach
"Histone H2BK120 can be deubiquitinated by the complex of USP43 and NuRD complex and be reactivated."
38613804
reach
"It has been discovered that the USP43/NuRD complex inhibits the expression of numerous cancer-related genes, including the epidermal growth factor receptor (EGFR)."
38613804
USP43 affects MTA3
4 |
USP43 binds MTA3. 4 / 4
4 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
USP43 affects FBXW7
| 4
USP43 inhibits FBXW7.
| 3
USP43 inhibits FBXW7. 2 / 2
| 2
reach
"Given that both USP43 and FBXW7 bind to the MBI of c-Myc, it seems reasonable to assume that increased USP43 may impede FBXW7’s access to c-Myc."
38218970
reach
"Overall, our results indicate that USP43 antagonizes the FBXW7-mediated degradation of c-Myc and cooperates with FBXW7 to regulate the migration ability of BLCA cells."
38218970
USP43 bound to MYC inhibits FBXW7. 1 / 1
| 1
reach
"Additionally, the interaction between USP43 and c-Myc reduces the proximity of FBXW7 to c-Myc, indirectly stabilizing it."
38218970
USP43 binds FBXW7.
| 1
USP43 binds FBXW7. 1 / 1
| 1
reach
"In BLCA, DNA polymerase POLD1 and the ubiquitin-specific protease USP43 competitively bind to MYC, preventing its interaction with FBXW7 and thereby stabilizing MYC protein levels."
39980052
USP43 affects EOC
| 4
USP43 activates EOC.
| 3
USP43 activates EOC. 3 / 3
| 3
reach
"In EOC, USP43 promotes the proliferation and impairs cisplatin sensitivity."
38613804
reach
"The study delves into the tumor-promoting impact in EOC, showing that USP43 enhances the proliferation, invasion, and migration of EOC, and facilitates EOC cells to enter the cell cycle’s proliferation phase.Cisplatin is a primary chemotherapeutic treatment for EOC."
38613804
reach
"USP43 promoted cell proliferation, migration, invasion and chemoresistance of EOC."
38087046
USP43 inhibits EOC.
| 1
USP43 inhibits EOC. 1 / 1
| 1
reach
"Our results indicated that USP43 reduced the sensitivity of EOC to cisplatin by decreasing apoptosis."
38087046
USP43 affects EGFR
| 4
USP43 inhibits EGFR.
| 2
USP43 bound to NuRD inhibits EGFR. 2 / 2
| 2
reach
"The USP43/NuRD complex inhibits the activity of EGFR and AKT, while the EGFR/PI3K/AKT signaling pathway regulates the behavior of USP43."
38613804
reach
"It has been discovered that the USP43/NuRD complex inhibits the expression of numerous cancer-related genes, including the epidermal growth factor receptor (EGFR)."
38613804
USP43 increases the amount of EGFR.
| 1
USP43 increases the amount of EGFR. 1 / 1
| 1
reach
"For example, as USP43 downregulation may promote breast cancer pathogenesis by altering H2Bub1-mediated regulation of EGFR expression (Section 5.1 ), an epigenome editing tool that selectively rescues[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34953650
USP43 activates EGFR.
| 1
USP43 activates EGFR. 1 / 1
| 1
reach
"Ubiquitin-specific peptidase 43 initiates the progression of breast cancer by interacting with the nucleosome remodeling and deacetylase (NuRD) complex , catalyzing H2BK120 deubiquitylation, and subse[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37328395
USP43 affects CDH2
| 4
Modified USP43 increases the amount of CDH2. 2 / 2
| 2
reach
"Therefore, USP43 overexpression in DLD1 cells could promote and inhibit the protein expressions of N-cadherin and Vimentin and protein expressions of N-cadherin, respectively."
33391437
reach
"Moreover, USP43 overexpression in DLD1 cells could effectively increase protein expressions of N-cadherin and Vimentin (P < 0.01)."
33391437
USP43 increases the amount of CDH2. 2 / 2
| 2
reach
"USP43 knockdown in SW480 cells could effectively inhibit protein expressions of N-cadherin and Vimentin (P < 0.01)."
33391437
reach
"Meanwhile, USP43 knockdown in SW480 cells could inhibit and promote the protein expressions of N-cadherin and Vimentin and protein expressions of N-cadherin, respectively."
33391437
USP43 affects CDH1
2 | 2
USP43 decreases the amount of CDH1.
| 2
Modified USP43 decreases the amount of CDH1. 1 / 1
| 1
reach
"However, USP43 overexpression in DLD1 cells could effectively inhibit E-cadherin protein expressions (P < 0.01)."
33391437
USP43 decreases the amount of CDH1. 1 / 1
| 1
reach
"However, USP43 knockdown in SW480 cells could effectively promote protein expressions of E-cadherin (P < 0.01)."
33391437
USP43 binds CDH1.
2 |
CDH1 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
37756605
CDH1 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
25468996
TAFAZZIN affects USP43
| 3 1
TAFAZZIN binds USP43.
| 2 1
USP43 binds TAFAZZIN. 3 / 3
| 2 1
sparser
"Immunofluorescence staining and co-immunoprecipitation (Co-IP) assays were used to explore the interaction between USP43 and TAZ."
39922114
reach
"Immunofluorescence staining and co-immunoprecipitation (Co-IP) assays were used to explore the interaction between USP43 and TAZ."
39922114
reach
"Co-IP and ubiquitination assays revealed that USP43 interacted with and stabilized TAZ by inhibiting TAZ ubiquitination."
39922114
TAFAZZIN inhibits USP43.
| 1
TAFAZZIN inhibits USP43. 1 / 1
| 1
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
NuRD affects USP43
| 4
USP43 binds NuRD. 4 / 4
| 4
reach
"The USP43/NuRD complex inhibits the activity of EGFR and AKT, while the EGFR/PI3K/AKT signaling pathway regulates the behavior of USP43."
38613804
reach
"Therefore, it has been established that the USP43/NuRD complex inhibits the growth, invasion, and metastasis of breast cancer cells; thus, USP43 may serve as a suppressor of breast cancer."
38613804
reach
"Histone H2BK120 can be deubiquitinated by the complex of USP43 and NuRD complex and be reactivated."
38613804
reach
"It has been discovered that the USP43/NuRD complex inhibits the expression of numerous cancer-related genes, including the epidermal growth factor receptor (EGFR)."
38613804
MTA3 affects USP43
4 |
USP43 binds MTA3. 4 / 4
4 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
HDAC2 affects USP43
2 | 1 1
USP43 binds HDAC2. 4 / 4
2 | 1 1
biogrid
No evidence text available
30135474
reach
"The interaction between USP43 and HDAC2 was confirmed by Co-IP assay (Fig. 9C)."
38087046
sparser
"The interaction between USP43 and HDAC2 was confirmed by Co-IP assay (Fig.  xref C)."
38087046
biogrid
No evidence text available
30135474
YWHAH affects USP43
3 |
USP43 binds YWHAH. 3 / 3
3 |
biogrid
No evidence text available
36931259
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
USP43 affects pdaC
| 3
USP43 activates pdaC.
| 2
USP43 activates pdaC. 2 / 2
| 2
reach
"High USP43 Expression Promote Proliferation of PDAC."
37050932
reach
"Experiments in vitro established that USP43 enhanced the proliferation of PDAC and that the overexpression or knockdown of USP43 promoted or inhibited the proliferation of PDAC, respectively."
37050932
USP43 inhibits pdaC.
| 1
USP43 inhibits pdaC. 1 / 1
| 1
reach
"USP43 Inhibits CD8 + T Cell Activation in PDAC."
37050932
USP43 affects calcium(2+)
| 3
USP43 activates calcium(2+). 3 / 3
| 3
reach
"To further investigate if USP43 mediated the function of Ca 2.2 in metastasis in vivo, we transplanted luciferase-tagged MDA-MB-436 cells stably expressing Ca 2.2 shRNA and USP43 cDNA constructs into mice."
36137995
reach
"To determine whether USP43 mediated the functions of Ca 2.2, we introduced Ca 2.2 shRNA and USP43 cDNA constructs into breast cancer cells."
36137995
reach
"Immunoblotting showed that cortactin expression was stabilized in Ca 2.2 knock-down cells expressing USP43 (Fig. 6A), indicating USP43 mediated the function of Ca 2.2 in cortactin stabilization."
36137995
USP43 affects YWHAH
3 |
USP43 binds YWHAH. 3 / 3
3 |
biogrid
No evidence text available
36931259
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
USP43 affects Ubiquitin
| 3
USP43 inhibits Ubiquitin.
| 2
USP43 inhibits Ubiquitin. 2 / 2
| 2
reach
"Mechanically, USP43 activated the Wnt/β-catenin signaling pathway through inhibiting ubiquitin-mediated degradation of HDAC2 to induce EOC cell chemoresistance.USP43 functions as a tumor promoter in multiple cancers."
38087046
reach
"USP43 inhibited ubiquitin-mediated degradation of HDAC2 in EOC cells."
38087046
USP43 activates Ubiquitin.
| 1
USP43 activates Ubiquitin. 1 / 1
| 1
reach
"Knock-down of USP43 increased the addition of ubiquitin on cortactin (Fig. 5H)."
36137995
USP43 affects HDAC1
3 |
USP43 binds HDAC1. 3 / 3
3 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
USP43 affects Cell Survival
| 3
USP43 activates Cell Survival.
| 2
USP43 activates Cell Survival. 2 / 2
| 2
reach
"The results suggested that USP43 knockdown treated SW480 cells could significantly decrease cell survival in three different drug treatments compared with that in normal SW480 cells (P < 0.05)."
33391437
reach
"However, USP43 overexpression in DLD1 cells could effectively promote cell survival in three different drug treatments compared with that in normal DLD1 cells (P < 0.05)."
33391437
USP43 inhibits Cell Survival.
| 1
USP43 inhibits Cell Survival. 1 / 1
| 1
reach
"Figure XREF_FIG G and Figure XREF_FIG H suggested that ZEB1 over-expression and knockdown treatments could effectively reverse the changes in cell survival rate caused by USP43 knockdown and overexpression treatment in the chemotherapy sensitivity analysis (P < 0.01)."
33391437
reach
"USP43 promotes the proliferation of epithelial ovarian cancer (EOC) and impairs its cisplatin sensitivity."
38613804
reach
"Notably, online database studies revealed frequent alterations and/or lack of USP43 in numerous types of cancer, thereby compelling further investigation into its function in the progression of cancer and potential targets as a novel therapeutic approach.Studies in databases and clinicopathological specimens have confirmed that USP43 expression is significantly elevated in breast, pancreatic, lung, bladder, and epithelial ovarian cancers."
38613804
USP43 inhibits Carcinoma, Ovarian Epithelial. 1 / 1
| 1
reach
"USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/beta-catenin signaling pathway."
38087046
HDAC1 affects USP43
3 |
USP43 binds HDAC1. 3 / 3
3 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
Air Pollutants affects USP43
3 |
Air Pollutants increases the amount of USP43.
2 |
Air Pollutants increases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
34911549
ctd
No evidence text available
38156290
Air Pollutants decreases the amount of USP43.
1 |
Air Pollutants decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
38156290
Vorinostat affects USP43
2 |
Vorinostat increases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Titanium dioxide affects USP43
2 |
Titanium dioxide increases the amount of USP43.
1 |
Titanium dioxide increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
29264374
Titanium dioxide demethylates USP43.
1 |
Titanium dioxide demethylates USP43. 1 / 1
1 |
ctd
No evidence text available
35295148
Pirinixic acid affects USP43
2 |
Pirinixic acid decreases the amount of USP43.
1 |
Pirinixic acid decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates USP43.
1 |
Pirinixic acid activates USP43. 1 / 1
1 |
ctd
No evidence text available
19710929
Phenylmercury acetate increases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
26272509
ctd
No evidence text available
27188386
Paracetamol affects USP43
2 |
Paracetamol decreases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
33387578
ctd
No evidence text available
29067470
P-chloromercuribenzoic acid increases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
Entinostat affects USP43
2 |
Entinostat increases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
27188386
ctd
No evidence text available
26272509
Benzo[a]pyrene affects USP43
2 |
Benzo[a]pyrene methylates USP43.
1 |
Benzo[a]pyrene methylates USP43. 1 / 1
1 |
ctd
No evidence text available
27901495
Benzo[a]pyrene decreases the amount of USP43.
1 |
Benzo[a]pyrene decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
32234424
Aflatoxin B1 affects USP43
2 |
Aflatoxin B1 increases the amount of USP43.
1 |
Aflatoxin B1 increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
19770486
Aflatoxin B1 decreases the amount of USP43.
1 |
Aflatoxin B1 decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
22100608
YWHAG affects USP43
2 |
YWHAG binds USP43. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
36931259
USP43 affects cell migration
| 2
reach
"USP43 knockdown in SW480 cells could significantly inhibit cell migration and invasion compared to that in the normal SW480 cells (P < 0.01)."
33391437
reach
"However, USP43 overexpression in DLD1 cells could promote cell migration and invasion compared to that in the normal DLD1 cells (P < 0.01)."
33391437
USP43 affects YWHAG
2 |
YWHAG binds USP43. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
36931259
USP43 affects MBD3
2 |
USP43 binds MBD3. 2 / 2
2 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
USP43 affects Interferon
| 2
USP43 inhibits Interferon.
| 1
USP43 inhibits Interferon. 1 / 1
| 1
reach
"In the 2 megabases region around MYH13 and MYH8 we found only three genes which could be involved in the fight against SIV: i) Synthaxin 8, a vesicle trafficking protein that functions in the early secretory pathway, ii) USP43 (Ubiquitin-Specific-Processing Protease 43) which negatively regulates type 1 IFN signaling by downregulating the JAK–STAT pathway, iii) ADPRM (ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent) knockdown of which by shRNA inhibits HIV-1 replication in cultured Jurkat T-cells (PMID: 19460752)."
29739964
USP43 decreases the amount of Interferon.
| 1
USP43 decreases the amount of Interferon. 1 / 1
| 1
reach
"This study demonstrated that USP43, as a deubiquitinating enzyme, negatively regulates the expression of type I interferon (IFN) and the Usp43 deficient enhances antiviral innate immune response against VSV infection both in vitro and in vivo."
40148469
USP43 affects DOC2B
| 2
USP43 binds DOC2B. 2 / 2
| 2
sparser
"The Z-score values of these features were all positive for the DOC2B-USP43 FO sequence (Fig.  xref , bottom right)."
37770423
sparser
"For the DOC2B-USP43 FO, analysis of SHAP contribution values revealed that the feature, “Net chrg. per AA”, was the largest positive contributor, and the additional features, “ABT balance”, “ABT valence”, and “Fraction pos."
37770423
USP43 affects DNA Damage
| 2
USP43 inhibits DNA Damage.
| 1
USP43 inhibits DNA Damage. 1 / 1
| 1
reach
"USP43 suppressed DNA damage and apoptosis, thereby reducing the sensitivity of EOC cells to cisplatin."
38613804
USP43 activates DNA Damage.
| 1
USP43 activates DNA Damage. 1 / 1
| 1
reach
"Given that DNA damage is a most prominent mechanism of cisplatin for cancer treatment [24], we further explored the effect of USP43 on cisplatin-induced DNA damage."
38087046
USP43 affects Carcinogenesis
| 1 1
USP43 activates Carcinogenesis. 2 / 2
| 1 1
reach
"In addition, high expression of USP43 was accompanied by malignant phenotypes in EOC, suggesting that USP43 promotes tumorigenesis in EOC.Ubiquitination is one of the vital post-translational modifications of proteins, which plays a crucial role in regulation of cell apoptosis [28, 29]."
38087046
eidos
"In addition , USP43 could promote tumorigenesis by regulating cell cycle and EMT process in breast cancer 14 ."
33391437
USP43 affects CHD4
2 |
USP43 binds CHD4. 2 / 2
2 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
USP1 affects USP43
1 | 1
USP1 increases the amount of USP43.
| 1
USP1 increases the amount of USP43. 1 / 1
| 1
reach
"Comparing the mRNA expression of USP1 and USP43 in EWS cell lines from DepMap portal (32), USP1 is overexpressed in EWS cell lines compared with USP43 (Fig. 1C)."
37478161
USP1 binds USP43.
1 |
USP43 binds USP1. 1 / 1
1 |
biogrid
No evidence text available
26496610
Particulate Matter increases the amount of USP43.
1 |
Particulate Matter increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
38156290
Particulate Matter decreases the amount of USP43.
1 |
Particulate Matter decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
38156290
NFATC4 affects USP43
| 1 1
NFATC4 increases the amount of USP43.
| 1
NFATC4 increases the amount of USP43. 1 / 1
| 1
reach
"We found that depletion of NFAT2 and NFAT3 could significantly reduced USP43 mRNA expression (Fig. 7D, Supplementary Fig. 11)."
36137995
NFATC4 binds USP43.
| 1
NFATC4 binds USP43. 1 / 1
| 1
sparser
"It is possible that NFAT3 binds to the other regions of USP43 promoter or indirectly regulates USP43 expression."
36137995
MBD3 affects USP43
2 |
USP43 binds MBD3. 2 / 2
2 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
DOC2B affects USP43
| 2
USP43 binds DOC2B. 2 / 2
| 2
sparser
"The Z-score values of these features were all positive for the DOC2B-USP43 FO sequence (Fig.  xref , bottom right)."
37770423
sparser
"For the DOC2B-USP43 FO, analysis of SHAP contribution values revealed that the feature, “Net chrg. per AA”, was the largest positive contributor, and the additional features, “ABT balance”, “ABT valence”, and “Fraction pos."
37770423
CTTN affects USP43
| 2
USP43 binds CTTN. 2 / 2
| 2
sparser
"We first determined whether USP43 interacted with cortactin."
36137995
sparser
"Immunoprecipitation showed that USP43 interacted with cortactin in MDA-MB-231 cells (Fig. xref )."
36137995
CHD4 affects USP43
2 |
USP43 binds CHD4. 2 / 2
2 |
biogrid
No evidence text available
30135474
biogrid
No evidence text available
30135474
CDH1 affects USP43
2 |
CDH1 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
37756605
CDH1 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
25468996
AKT affects USP43
| 1 1
AKT phosphorylates USP43.
| 1
AKT phosphorylates USP43. 1 / 1
| 1
rlimsp
"Interestingly, USP43 also exists in the cytoplasm, where it is phosphorylated by AKT, enabling its binding to the 14-3-3β/ε heterodimer and sequestration in the cytoplasm."
30135474
AKT activates USP43.
| 1
AKT activates USP43. 1 / 1
| 1
reach
"Phosphorylation by AKT enables USP43 to interact with the 14-3-3β/ε heterodimer and remain localized in the cytoplasm."
38613804
6-propyl-2-thiouracil increases the amount of USP43.
1 |
6-propyl-2-thiouracil increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
24780913
6-propyl-2-thiouracil decreases the amount of USP43.
1 |
6-propyl-2-thiouracil decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25825206
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP43. 2 / 2
2 |
ctd
No evidence text available
33387578
ctd
No evidence text available
32109520
Vinclozolin affects USP43
1 |
Vinclozolin methylates USP43. 1 / 1
1 |
ctd
No evidence text available
31079544
Triptonide affects USP43
1 |
Triptonide decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
33045310
Trichloroethene affects USP43
1 |
Trichloroethene decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
33387578
Tributylstannane affects USP43
1 |
Tributylstannane increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31939706
Thioacetamide affects USP43
1 |
Thioacetamide increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
23411599
Tetrachloromethane increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31150632
Systhane affects USP43
1 |
Systhane increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
32268158
Sulforaphane affects USP43
1 |
Sulforaphane decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31838189
Sodium lactate affects USP43
1 |
Sodium lactate increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
39922521
Sodium dodecyl sulfate increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31734321
Sodium arsenite affects USP43
1 |
Sodium arsenite decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
37682722
Rosiglitazone affects USP43
1 |
Rosiglitazone increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
21515302
Quinolin-8-ol affects USP43
1 |
Quinolin-8-ol decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
21632981
Quercetin affects USP43
1 |
Quercetin decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
21632981
Permethrin affects USP43
1 |
Permethrin methylates USP43. 1 / 1
1 |
ctd
No evidence text available
33148267
Perfluorooctane-1-sulfonic acid decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
36331819
Panobinostat affects USP43
1 |
Panobinostat increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
27188386
Ozone affects USP43
1 |
Ozone increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
34911549
Nickel monoxide affects USP43
1 |
Nickel monoxide increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
19167457
Mercury dibromide affects USP43
1 |
Mercury dibromide increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
27188386
Manganese(II) chloride increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
28801915
Leflunomide affects USP43
1 |
Leflunomide increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
28988120
Ketamine affects USP43
1 |
Ketamine decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
20080153
Jinfukang affects USP43
1 |
Jinfukang decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
27392435
Inulin affects USP43
1 |
Inulin decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
36331819
Folic acid affects USP43
1 |
Folic acid demethylates USP43. 1 / 1
1 |
ctd
No evidence text available
20938992
Dual-luciferase affects USP43
| 1
Dual-luciferase activates USP43. 1 / 1
| 1
reach
"The dual-luciferase reporter assay revealed that exogenous c-Myc significantly increased the activity of the USP43 promoter."
38218970
Dorsomorphin affects USP43
1 |
Dorsomorphin increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
27188386
Domoic acid affects USP43
1 |
Domoic acid increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
36102641
Decabromodiphenyl ether increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
23914054
Cytokine affects USP43
| 1
sparser
"Because USP43 is so tightly associated with cytokines, we looked for which cytokines in the broad cytokine family were related to USP43 and found to be strongly inversely associated with CXCL12 expression ( xref )."
37050932
Clothianidin affects USP43
1 |
Clothianidin decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31626844
Cisplatin affects USP43
1 |
Cisplatin decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
27392435
Choline affects USP43
1 |
Choline demethylates USP43. 1 / 1
1 |
ctd
No evidence text available
20938992
Chloroprene affects USP43
1 |
Chloroprene increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
23125180
Caffeine affects USP43
1 |
Caffeine dephosphorylates USP43. 1 / 1
1 |
ctd
No evidence text available
35688186
Bis(2-ethylhexyl) phthalate increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31163220
Beta-lapachone affects USP43
1 |
Beta-lapachone decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
38218311
Aristolochic acid A increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
33212167
Acetamide affects USP43
1 |
Acetamide increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31881176
Abrine affects USP43
1 |
Abrine increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
31054353
YWHAZ affects USP43
1 |
YWHAZ binds USP43. 1 / 1
1 |
biogrid
No evidence text available
36931259
YWHAQ affects USP43
1 |
YWHAQ binds USP43. 1 / 1
1 |
biogrid
No evidence text available
36931259
XPO7 affects USP43
1 |
XPO7 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
36897256
WDR3 affects USP43
1 |
USP43 binds WDR3. 1 / 1
1 |
biogrid
No evidence text available
19615732
Vehicle Emissions affects USP43
1 |
ctd
No evidence text available
25560391
VPS35 affects USP43
1 |
USP43 binds VPS35. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects migration
| 1
USP43 activates migration. 1 / 1
| 1
eidos
"USP43 could promote cell proliferation , invasion , and migration in colorectal cancer by regulating ZEB1 ubiquitylation degradation ."
33391437
USP43 affects migration invasion colorectal cancer
| 1
USP43 activates migration invasion colorectal cancer. 1 / 1
| 1
eidos
"USP43 could promote the proliferation , migration , and invasion of colorectal cancer ."
33391437
USP43 affects metastasis colorectal cancer Colorectal cancer
| 1
USP43 activates metastasis colorectal cancer Colorectal cancer. 1 / 1
| 1
eidos
"USP43 directly regulates ZEB1 protein , mediating proliferation and metastasis of colorectal cancer Colorectal cancer is one of the most common malignant tumors of the digestive tract ."
33391437
USP43 affects growth metastasis breast cancer
| 1
USP43 inhibits growth metastasis breast cancer. 1 / 1
| 1
eidos
"Meanwhile , previous study indicated that USP43 could remarkably inhibit the growth and metastasis of breast cancer though affecting EGFR / PI3K / AKT 13 ."
33391437
USP43 affects cytokine
| 1
sparser
"Because USP43 is so tightly associated with cytokines, we looked for which cytokines in the broad cytokine family were related to USP43 and found to be strongly inversely associated with CXCL12 expression ( xref )."
37050932
USP43 affects colorectal cancer cells probe biological function USP43 colorectal cancer cells
| 1
USP43 activates colorectal cancer cells probe biological function USP43 colorectal cancer cells. 1 / 1
| 1
eidos
"USP43 promotes proliferation of colorectal cancer cells in vitro To further probe the biological function of USP43 in colorectal cancer cells , we have studied USP43 expressions in five selected cell lines , including FHC , HCT116 , SW480 , DLD1 , and LOVO ."
33391437
USP43 affects cell growth
| 1
USP43 inhibits cell growth. 1 / 1
| 1
reach
"The promoter of nuclear anchoring protein Sun2 (FDR = 0.03 and FDR = 0.002), a lack of which causes cardiac hypertrophy via enhanced AKT/MAPK signaling in the absence of fibrosis, also remained hypermethylated following detraining, as did Usp43 (FDR = 0.0007 and FDR = 0.006), which strongly suppresses cell growth (Figure 3C)."
34870208
USP43 affects cell cycle
| 1
USP43 activates cell cycle. 1 / 1
| 1
reach
"In addition, USP43 could promote tumorigenesis by regulating cell cycle and EMT process in breast cancer XREF_BIBR."
33391437
USP43 affects ZEB1 protein
| 1
USP43 inhibits ZEB1 protein. 1 / 1
| 1
eidos
"Moreover , USP43 can reduce ZEB1 protein expression without affecting its transcription ."
33391437
USP43 affects YWHAZ
1 |
YWHAZ binds USP43. 1 / 1
1 |
biogrid
No evidence text available
36931259
USP43 affects YWHAQ
1 |
YWHAQ binds USP43. 1 / 1
1 |
biogrid
No evidence text available
36931259
USP43 affects XPO7
1 |
XPO7 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
36897256
USP43 affects WDR3
1 |
USP43 binds WDR3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects VPS35
1 |
USP43 binds VPS35. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects USP1
1 |
USP43 binds USP1. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects TXNL4A
1 |
USP43 binds TXNL4A. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects TRMT6
1 |
USP43 binds TRMT6. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects TRIM56
1 |
USP43 binds TRIM56. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects TMEM165
1 |
USP43 binds TMEM165. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects TBK1
| 1
USP43 leads to the ubiquitination of TBK1. 1 / 1
| 1
reach
"The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation."
40148469
USP43 affects STX10
1 |
USP43 binds STX10. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects SSR3
1 |
USP43 binds SSR3. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects SNAI1
1 |
SNAI1 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
31911859
USP43 affects S
1 |
S binds USP43. 1 / 1
1 |
biogrid
No evidence text available
37499664
USP43 affects S phase
| 1
USP43 activates S phase. 1 / 1
| 1
reach
"USP43 overexpression was observed to induced a decrease in G1-phase and G2-phase cells and an increase in S-phase cells (Fig. 4B)."
38087046
USP43 affects RNF2
| 1
USP43 deubiquitinates RNF2. 1 / 1
| 1
reach
"Here, we reveal that E3 ubiquitin ligase ring finger protein 2 (RNF2) is deubiquitinated and stabilized by ubiquitin specific peptidase 43 (USP43) through interactome and quantitative ubiquitinome mass spectrometry analysis."
40148469
USP43 affects RFFL
1 |
RFFL binds USP43. 1 / 1
1 |
biogrid
No evidence text available
30659120
USP43 affects RELA
1 |
RELA binds USP43. 1 / 1
1 |
biogrid
No evidence text available
33438746
USP43 affects RBBP7
1 |
USP43 binds RBBP7. 1 / 1
1 |
biogrid
No evidence text available
30135474
USP43 affects RBBP4
1 |
USP43 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
30135474
USP43 affects PSME3
1 |
USP43 binds PSME3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects PSMA2
1 |
USP43 binds PSMA2. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects POLD1
1 |
USP43 binds POLD1. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects PDCD2
1 |
USP43 binds PDCD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects PCNA
| 1
USP43 activates PCNA. 1 / 1
| 1
reach
"Subsequently, deISGylation by USP43 enables PCNA to rebind to replicative DNA polymerases in order to resume normal DNA replication [46]."
37728310
USP43 affects PANC02
| 1
USP43 activates PANC02. 1 / 1
| 1
reach
"USP43 overexpression promoted PANC-1 cell proliferation (P = 0.0018), but USP43 knockdown decreased PANC02 cell proliferation (P < 0.001)."
37050932
USP43 affects Osteosarcoma
| 1
USP43 inhibits Osteosarcoma. 1 / 1
| 1
reach
"Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619."
34571917
USP43 affects NHS
1 |
USP43 binds NHS. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects NFATC4
| 1
NFATC4 binds USP43. 1 / 1
| 1
sparser
"It is possible that NFAT3 binds to the other regions of USP43 promoter or indirectly regulates USP43 expression."
36137995
USP43 affects NFATC1
| 1
USP43 binds NFATC1. 1 / 1
| 1
sparser
"We used Chromatin Immunoprecipitation (ChIP) analysis to further determined the direct interactions of NFAT2 with USP43 promoter in MDA-MB-231 cells, ChIP analysis indicated the significant enrichment of USP43 promoter as well as BMI1 promoter which is a well-established direct target gene of NFAT2 [ xref ] and served as a control in NFAT2 immunoprecipitation (Fig. xref , Supplementary Fig. xref )."
36137995
USP43 affects NCOA4
1 |
USP43 binds NCOA4. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects MRPS12
1 |
USP43 binds MRPS12. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects MBI
| 1
USP43 binds MBI. 1 / 1
| 1
reach
"Given that both USP43 and FBXW7 bind to the MBI of c-Myc, it seems reasonable to assume that increased USP43 may impede FBXW7’s access to c-Myc."
38218970
USP43 affects MARCHF5
1 |
MARCHF5 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
34964862
USP43 affects MAPT
1 |
USP43 binds MAPT. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects MAGI3
1 |
USP43 binds MAGI3. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects LDHA-luciferase
| 1
USP43 activates LDHA-luciferase. 1 / 1
| 1
reach
"The dual-luciferase reporter assay showed that USP43 could further enhance the activation of LDHA-luciferase by c-Myc (Fig. 1G)."
38218970
USP43 affects LCOR
1 |
USP43 binds LCOR. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects K148/289R
| 1
USP43 deubiquitinates K148/289R. 1 / 1
| 1
reach
"Further deubiquitination assays showed that USP43 was able to deubiquitinate wild-type c-Myc but not the c-Myc mutants K148R, K289R, and K148/289R (Fig. 5J)."
38218970
USP43 affects INTS1
1 |
USP43 binds INTS1. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects Histone_H3
| 1
USP43 leads to the deacetylation of Histone_H3. 1 / 1
| 1
reach
"Thus, USP43 depletion not only abolishes H2Bub1 deposition but also inhibits H3 deacetylation [ 42 ]."
34953650
USP43 affects Histone
| 1
USP43 deubiquitinates Histone. 1 / 1
| 1
reach
"Histone H2BK120 can be deubiquitinated by the complex of USP43 and NuRD complex and be reactivated."
38613804
USP43 affects Hippo
| 1
USP43 activates Hippo. 1 / 1
| 1
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
USP43 affects HSPA8
1 |
USP43 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
30135474
USP43 affects HSPA1A
1 |
USP43 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
30135474
USP43 affects HRAS
1 |
HRAS binds USP43. 1 / 1
1 |
biogrid
No evidence text available
30639242
USP43 affects HIF1
| 1
USP43 activates HIF1. 1 / 1
| 1
reach
"Mechanistically, USP43 associates with 14-3-3 proteins in a hypoxia and phosphorylation dependent manner to increase the nuclear pool of HIF-1."
39009674
USP43 affects HAUS5
1 |
USP43 binds HAUS5. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects H2Bub1
| 1
Mutated USP43 inhibits H2Bub1. 1 / 1
| 1
reach
"Remarkably, certain USP43 mutations promote cytoplasmic sequestration of USP43 and/or impaired H2Bub1 removal that compromises EGFR repression."
34953650
USP43 affects H2BC3
1 |
USP43 binds H2BC3. 1 / 1
1 |
biogrid
No evidence text available
30135474
USP43 affects H2B
1 |
USP43 binds H2B. 1 / 1
1 |
biogrid
No evidence text available
30135474
USP43 affects H2AX
| 1
USP43 activates H2AX. 1 / 1
| 1
reach
"In addition, the protein levels of cleaved PARP, cleaved caspase-3 and γH2AX induced by USP43 overexpression were further elevated by silencing HDAC2 (Fig. 10E)."
38087046
USP43 affects Flag
| 1
USP43 binds Flag. 1 / 1
| 1
sparser
"Our results demonstrated a strong interaction between exogenously expressed Flag-USP43 and HA-c-Myc in 293 T cells (Fig. xref ), while recombinant GST-c-Myc pulled down recombinant His-USP43 in vitro (Fig. xref )."
38218970
USP43 affects FTSJ1
1 |
USP43 binds FTSJ1. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects FN3KRP
1 |
USP43 binds FN3KRP. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP43 affects EPAS1
| 1
EPAS1 binds USP43. 1 / 1
| 1
sparser
"No association of endogenous or overexpressed USP43 with HIF-2α was observed (Fig.  xref ), consistent with the HIF-1α specificity observed in the ccRCC lines."
39009674
USP43 affects E3_Ub_ligase
| 1
USP43 deubiquitinates E3_Ub_ligase. 1 / 1
| 1
reach
"Here, we reveal that E3 ubiquitin ligase ring finger protein 2 (RNF2) is deubiquitinated and stabilized by ubiquitin specific peptidase 43 (USP43) through interactome and quantitative ubiquitinome mass spectrometry analysis."
40148469
USP43 affects DDX11
1 |
USP43 binds DDX11. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects Cyclin
| 1
USP43 increases the amount of Cyclin. 1 / 1
| 1
reach
"In addition, the expression of CDK4, CDK6 and cyclin D1 was downregulated upon USP43 silencing (Fig. 4C) and upregulated by USP43 overexpression (Fig. 4D), which contributes to cell entry into the proliferation cycle."
38087046
USP43 affects CTNNB1
1 |
USP43 binds CTNNB1. 1 / 1
1 |
biogrid
No evidence text available
30323974
USP43 affects CSNK2B
1 |
USP43 binds CSNK2B. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects CEP57
1 |
USP43 binds CEP57. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects CDK6
| 1
USP43 increases the amount of CDK6. 1 / 1
| 1
reach
"In addition, the expression of CDK4, CDK6 and cyclin D1 was downregulated upon USP43 silencing (Fig. 4C) and upregulated by USP43 overexpression (Fig. 4D), which contributes to cell entry into the proliferation cycle."
38087046
USP43 affects CDK5RAP2
1 |
USP43 binds CDK5RAP2. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects CDK4
| 1
USP43 increases the amount of CDK4. 1 / 1
| 1
reach
"In addition, the expression of CDK4, CDK6 and cyclin D1 was downregulated upon USP43 silencing (Fig. 4C) and upregulated by USP43 overexpression (Fig. 4D), which contributes to cell entry into the proliferation cycle."
38087046
USP43 affects CC
| 1
USP43 activates CC. 1 / 1
| 1
reach
"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
39922114
USP43 affects CASP3
| 1
USP43 activates CASP3. 1 / 1
| 1
reach
"In addition, the protein levels of cleaved PARP, cleaved caspase-3 and γH2AX induced by USP43 overexpression were further elevated by silencing HDAC2 (Fig. 10E)."
38087046
USP43 affects BLCA
| 1
USP43 activates BLCA. 1 / 1
| 1
reach
"Moreover, USP43 may stimulate the metastasis of BLCA."
38613804
USP43 affects ATG4A
1 |
USP43 binds ATG4A. 1 / 1
1 |
biogrid
No evidence text available
26496610
USP43 affects AKT
| 1
USP43 bound to NuRD inhibits AKT. 1 / 1
| 1
reach
"The USP43/NuRD complex inhibits the activity of EGFR and AKT, while the EGFR/PI3K/AKT signaling pathway regulates the behavior of USP43."
38613804
USP43 affects 7b
1 |
7b binds USP43. 1 / 1
1 |
biogrid
No evidence text available
| DOI
Tobacco Smoke Pollution decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
33660061
TXNL4A affects USP43
1 |
USP43 binds TXNL4A. 1 / 1
1 |
biogrid
No evidence text available
26496610
TRMT6 affects USP43
1 |
USP43 binds TRMT6. 1 / 1
1 |
biogrid
No evidence text available
26496610
TRIM56 affects USP43
1 |
USP43 binds TRIM56. 1 / 1
1 |
biogrid
No evidence text available
26496610
TMEM165 affects USP43
1 |
USP43 binds TMEM165. 1 / 1
1 |
biogrid
No evidence text available
26496610
Soot affects USP43
1 |
Soot increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
34911549
Smoke affects USP43
1 |
Smoke decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
34520756
STX10 affects USP43
1 |
USP43 binds STX10. 1 / 1
1 |
biogrid
No evidence text available
26496610
SSR3 affects USP43
1 |
USP43 binds SSR3. 1 / 1
1 |
biogrid
No evidence text available
26496610
SNAI1 affects USP43
1 |
SNAI1 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
31911859
S affects USP43
1 |
S binds USP43. 1 / 1
1 |
biogrid
No evidence text available
37499664
RFFL affects USP43
1 |
RFFL binds USP43. 1 / 1
1 |
biogrid
No evidence text available
30659120
RELA affects USP43
1 |
RELA binds USP43. 1 / 1
1 |
biogrid
No evidence text available
33438746
RBBP7 affects USP43
1 |
USP43 binds RBBP7. 1 / 1
1 |
biogrid
No evidence text available
30135474
RBBP4 affects USP43
1 |
USP43 binds RBBP4. 1 / 1
1 |
biogrid
No evidence text available
30135474
PSME3 affects USP43
1 |
USP43 binds PSME3. 1 / 1
1 |
biogrid
No evidence text available
19615732
PSMA2 affects USP43
1 |
USP43 binds PSMA2. 1 / 1
1 |
biogrid
No evidence text available
26496610
POLD1 affects USP43
1 |
USP43 binds POLD1. 1 / 1
1 |
biogrid
No evidence text available
26496610
PDCD2 affects USP43
1 |
USP43 binds PDCD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
PCB138 affects USP43
1 |
PCB138 increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25510870
PCB 180 affects USP43
1 |
PCB 180 increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25510870
Osteosarcoma affects USP43
| 1
Osteosarcoma activates USP43. 1 / 1
| 1
reach
"USP43 potentially regulates cancer invasion by modulating EMT-associated transcription factors, such as ZEB1 or SNAIL, in breast cancer, colorectal cancer, and osteosarcoma."
38613804
NHS affects USP43
1 |
USP43 binds NHS. 1 / 1
1 |
biogrid
No evidence text available
26496610
NFATC3 affects USP43
| 1
NFATC3 decreases the amount of USP43. 1 / 1
| 1
reach
"However, the knock-down of NFAT1 and NFAT4 did not decrease USP43 mRNA expression (Supplementary Fig. 12)."
36137995
NFATC2 affects USP43
| 1
NFATC2 decreases the amount of USP43. 1 / 1
| 1
reach
"However, the knock-down of NFAT1 and NFAT4 did not decrease USP43 mRNA expression (Supplementary Fig. 12)."
36137995
NFAT affects USP43
| 1
NFAT increases the amount of USP43. 1 / 1
| 1
reach
"We then investigated whether NFAT proteins were able to modulate USP43 mRNA expression."
36137995
NCOA4 affects USP43
1 |
USP43 binds NCOA4. 1 / 1
1 |
biogrid
No evidence text available
26496610
N,N-diethyl-m-toluamide methylates USP43. 1 / 1
1 |
ctd
No evidence text available
33148267
MRPS12 affects USP43
1 |
USP43 binds MRPS12. 1 / 1
1 |
biogrid
No evidence text available
26496610
MBI affects USP43
| 1
USP43 binds MBI. 1 / 1
| 1
reach
"Given that both USP43 and FBXW7 bind to the MBI of c-Myc, it seems reasonable to assume that increased USP43 may impede FBXW7’s access to c-Myc."
38218970
MARCHF5 affects USP43
1 |
MARCHF5 binds USP43. 1 / 1
1 |
biogrid
No evidence text available
34964862
MAPT affects USP43
1 |
USP43 binds MAPT. 1 / 1
1 |
biogrid
No evidence text available
26496610
MAGI3 affects USP43
1 |
USP43 binds MAGI3. 1 / 1
1 |
biogrid
No evidence text available
19615732
LCOR affects USP43
1 |
USP43 binds LCOR. 1 / 1
1 |
biogrid
No evidence text available
26496610
L-methionine affects USP43
1 |
L-methionine demethylates USP43. 1 / 1
1 |
ctd
No evidence text available
20938992
INTS1 affects USP43
1 |
USP43 binds INTS1. 1 / 1
1 |
biogrid
No evidence text available
26496610
HSPA8 affects USP43
1 |
USP43 binds HSPA8. 1 / 1
1 |
biogrid
No evidence text available
30135474
HSPA1A affects USP43
1 |
USP43 binds HSPA1A. 1 / 1
1 |
biogrid
No evidence text available
30135474
HRAS affects USP43
1 |
HRAS binds USP43. 1 / 1
1 |
biogrid
No evidence text available
30639242
HAUS5 affects USP43
1 |
USP43 binds HAUS5. 1 / 1
1 |
biogrid
No evidence text available
26496610
H2BC3 affects USP43
1 |
USP43 binds H2BC3. 1 / 1
1 |
biogrid
No evidence text available
30135474
H2B affects USP43
1 |
USP43 binds H2B. 1 / 1
1 |
biogrid
No evidence text available
30135474
Gentamicins affects USP43
1 |
Gentamicins decreases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
33387578
Flag affects USP43
| 1
USP43 binds Flag. 1 / 1
| 1
sparser
"Our results demonstrated a strong interaction between exogenously expressed Flag-USP43 and HA-c-Myc in 293 T cells (Fig. xref ), while recombinant GST-c-Myc pulled down recombinant His-USP43 in vitro (Fig. xref )."
38218970
FTSJ1 affects USP43
1 |
USP43 binds FTSJ1. 1 / 1
1 |
biogrid
No evidence text available
26496610
FN3KRP affects USP43
1 |
USP43 binds FN3KRP. 1 / 1
1 |
biogrid
No evidence text available
19615732
FBXW7 affects USP43
| 1
USP43 binds FBXW7. 1 / 1
| 1
reach
"In BLCA, DNA polymerase POLD1 and the ubiquitin-specific protease USP43 competitively bind to MYC, preventing its interaction with FBXW7 and thereby stabilizing MYC protein levels."
39980052
EPAS1 affects USP43
| 1
EPAS1 binds USP43. 1 / 1
| 1
sparser
"No association of endogenous or overexpressed USP43 with HIF-2α was observed (Fig.  xref ), consistent with the HIF-1α specificity observed in the ccRCC lines."
39009674
Dietary Fats affects USP43
1 |
Dietary Fats increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25016146
DDX11 affects USP43
1 |
USP43 binds DDX11. 1 / 1
1 |
biogrid
No evidence text available
26496610
CTNNB1 affects USP43
1 |
USP43 binds CTNNB1. 1 / 1
1 |
biogrid
No evidence text available
30323974
CSNK2B affects USP43
1 |
USP43 binds CSNK2B. 1 / 1
1 |
biogrid
No evidence text available
26496610
CEP57 affects USP43
1 |
USP43 binds CEP57. 1 / 1
1 |
biogrid
No evidence text available
26496610
CDK5RAP2 affects USP43
1 |
USP43 binds CDK5RAP2. 1 / 1
1 |
biogrid
No evidence text available
26496610
ATG4A affects USP43
1 |
USP43 binds ATG4A. 1 / 1
1 |
biogrid
No evidence text available
26496610
AKT1 affects USP43
| 1
AKT1 phosphorylates USP43. 1 / 1
| 1
reach
"Based on the current understanding, P-AKT can phosphorylate numerous downstream effectors, including USP43, GSK3, FOXO1, which influences chromatin remodeling ( He et al., 2018 ), glucose metabolism, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33515539
7b affects USP43
1 |
7b binds USP43. 1 / 1
1 |
biogrid
No evidence text available
| DOI
2-hydroxypropanoic acid increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
39922521
1,2-dimethylhydrazine increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
22206623
2,4,5,2',5'-pentachlorobiphenyl increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25510870
2,4,4'-trichlorobiphenyl increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',5,5'-tetrachlorobiphenyl increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25510870
2,2',4,4',5,5'-hexachlorobiphenyl increases the amount of USP43. 1 / 1
1 |
ctd
No evidence text available
25510870