IndraLab

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USP43 inhibits apoptotic process. 5 / 5
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"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
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"HDAC2 silencing elevated apoptosis rate induced by overexpression of USP43 (Fig. 10D)."
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"Our results demonstrated that USP43 inhibition of apoptosis affected the sensitivity of EOC to cisplatin.High-level expression of HDAC2 promotes cancer progression through various signal pathways, including breast cancer [38, 39], non-small cell lung cancer [16], liver cancer [40]."
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"USP43 suppressed DNA damage and apoptosis, thereby reducing the sensitivity of EOC cells to cisplatin."
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"USP43 overexpression diminished cell apoptosis induced by cisplatin, and ICG-001 treatment restored this effect (Fig. 10L)."
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