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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP43 inhibits Interferon. 1 / 1

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reach

"In the 2 megabases region around MYH13 and MYH8 we found only three genes which could be involved in the fight against SIV: i) Synthaxin 8, a vesicle trafficking protein that functions in the early secretory pathway, ii) USP43 (Ubiquitin-Specific-Processing Protease 43) which negatively regulates type 1 IFN signaling by downregulating the JAK–STAT pathway, iii) ADPRM (ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent) knockdown of which by shRNA inhibits HIV-1 replication in cultured Jurkat T-cells (PMID: 19460752)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...