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USP43 activates Wnt/β-catenin. 4 / 4
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"Notably, knockdown of HDAC2 diminished the activation of Wnt/β-catenin signaling pathway caused by upregulation of USP43 (Fig. 10J, K)."
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"These results indicated that USP43 activated Wnt/β-catenin signaling pathway through HDAC2.To further determine whether USP43 regulates the sensitivity of EOC cells to cisplatin via the Wnt/β-catenin signaling pathway, EOC cells were co-treated with Wnt/β-catenin signaling pathway inhibitor ICG-001 and cisplatin."
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"Mechanically, USP43 activated the Wnt/β-catenin signaling pathway through inhibiting ubiquitin-mediated degradation of HDAC2 to induce EOC cell chemoresistance.USP43 functions as a tumor promoter in multiple cancers."
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"Further research found that USP43 induced activation of the Wnt/β-catenin signaling pathway by regulating HDAC2."
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