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USP43 activates calcium(2+). 3 / 3
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"To further investigate if USP43 mediated the function of Ca 2.2 in metastasis in vivo, we transplanted luciferase-tagged MDA-MB-436 cells stably expressing Ca 2.2 shRNA and USP43 cDNA constructs into mice."
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"To determine whether USP43 mediated the functions of Ca 2.2, we introduced Ca 2.2 shRNA and USP43 cDNA constructs into breast cancer cells."
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"Immunoblotting showed that cortactin expression was stabilized in Ca 2.2 knock-down cells expressing USP43 (Fig. 6A), indicating USP43 mediated the function of Ca 2.2 in cortactin stabilization."
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