IndraLab

Statements

USP43 inhibits cisplatin. 12 / 12
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"Taken together, our results suggested that USP43 impaired the sensitivity of EOC cells to cisplatin by activating the Wnt/β-catenin signaling pathway through HDAC2."
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"Notably, knockdown of USP43 enhanced cisplatin-induced apoptosis (Fig. 6C), while USP43 overexpression diminished the effect of cisplatin (Fig. 6D)."
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"In EOC, USP43 promotes the proliferation and impairs cisplatin sensitivity."
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"In the current study, we demonstrated that USP43 facilitated the malignant behaviors, and decreased the sensitivity of cisplatin to EOC cells."
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"These data suggested that USP43 reduced cisplatin sensitivity in EOC cells through suppressing DNA damage."
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"USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/beta-catenin signaling pathway."
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"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
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"To confirm whether HDAC2 is involved in the USP43-induced reduction of cisplatin sensitivity in EOC cells, USP43 over-expressed cells were transfected with si-HDAC2 or si-NC."
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"The overexpression of USP43 attenuated the inhibition of cisplatin on EOC cells, while HDAC2 silencing reversed the result (Fig. 10C)."
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"USP43 promotes the proliferation of epithelial ovarian cancer (EOC) and impairs its cisplatin sensitivity."
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"We revealed that USP43 inhibited cisplatin sensitivity, reduced the number of DNA breaks attacked by cisplatin, and double-strand breaks led to decrease expression of apoptosis proteins."
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"USP43 diminished the sensitivity of EOC cells to cisplatin through activation of the Wnt/beta-catenin signaling pathway mediated by HDAC2."
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