IndraLab

Statements

USP43 activates MYC. 5 / 5
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"This study reveals that USP43 promotes aerobic glycolysis and metastasis in BLCA by stabilizing c-Myc, thus providing a novel target for indirect inhibition of c-Myc."
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"To identify the lysine residue of c-Myc catalyzed by USP43, we constructed a series of c-Myc point mutant plasmids with lysine mutated to arginine."
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"We then constructed a double mutant of c-Myc and confirmed that K148 and K289 are indeed essential for USP43 catalysis of c-Myc (Fig. 5I and Supplementary Fig. S6F)."
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"USP43 antagonizes c-Myc degradation by FBXW7."
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"This partially explains the upregulation of USP43 in BLCA tissues, wherein amplified c-Myc increases USP43 mRNA levels."
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