IndraLab

Statements

USP43 activates Neoplasm Invasiveness. 14 / 14
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"USP43 potentially regulates cancer invasion by modulating EMT-associated transcription factors, such as ZEB1 or SNAIL, in breast cancer, colorectal cancer, and osteosarcoma."
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"In breast cancer, USP43 promotes invasion and metastasis through invadopodia formation."
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"Overexpression of TAZ reversed the inhibitory effects of USP43 silencing on CC cell proliferation, migration, invasion and EMT CONCLUSION: USP43 promotes CC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) by activating the Hippo/TAZ pathway."
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"USP43 knockdown in SW480 cells could significantly inhibit cell migration and invasion compared to that in the normal SW480 cells (P < 0.01)."
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"However, USP43 overexpression in DLD1 cells could promote cell migration and invasion compared to that in the normal DLD1 cells (P < 0.01)."
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"For instance, USP43 promoted cell proliferation, migration and invasion of colorectal cancer [12]."
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"Meanwhile, ZEB1overexpression could effectively reverse the changes in invasion caused by USP43 overexpression in SW480 cells (P < 0.01)."
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"USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis."
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"Furthermore, USP43 was highly expressed in colorectal cancer (CRC) and increased CRC cell proliferation, invasion, and migration [23]."
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"The study delves into the tumor-promoting impact in EOC, showing that USP43 enhances the proliferation, invasion, and migration of EOC, and facilitates EOC cells to enter the cell cycle’s proliferation phase.Cisplatin is a primary chemotherapeutic treatment for EOC."
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"USP43 could promote the proliferation, migration, and invasion of colorectal cancer."
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"USP43 could promote cell proliferation , invasion , and migration in colorectal cancer by regulating ZEB1 ubiquitylation degradation ."
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"Silencing of USP43 reduced cell proliferation, migration, invasion, and the epithelial-mesenchymal transition (EMT) process."
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"USP43 promoted cell proliferation, migration, invasion and chemoresistance of EOC."
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