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"We used Chromatin Immunoprecipitation (ChIP) analysis to further determined the direct interactions of NFAT2 with USP43 promoter in MDA-MB-231 cells, ChIP analysis indicated the significant enrichment of USP43 promoter as well as BMI1 promoter which is a well-established direct target gene of NFAT2 [ xref ] and served as a control in NFAT2 immunoprecipitation (Fig. xref , Supplementary Fig. xref )."