IndraLab

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USP43 deubiquitinates ZEB1. 6 / 7
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"USP43 can enhance CRC cell growth by inducing the deubiquitination of Zinc finger E-box-binding homeobox 1 (ZEB1) protein, which is closely associated with tumor cell proliferation, invasion, migration and expression of EMT-related biomarkers."
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"USP43 promoted cell proliferation, migration and invasion of colorectal cancer, and reduce the sensitivity of chemotherapy through deubiquitinating ZEB1 [12]."
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"In patients with osteosarcoma and lung metastasis, USP43 deubiquitinates ZEB1 and maintains its transcription [65], resulting in increased invasion of osteosarcoma cells via inducing EMT [88, 89]."
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"Meanwhile, USP43 can deubiquitinate and stabilize the ZEB1 protein, which plays an important role in the function of colorectal cancer."
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"USP43 could promote cell proliferation, invasion, and migration in colorectal cancer by regulating ZEB1 ubiquitylation degradation."
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"USP43 directly interacts with and deubiquitinates ZEB1, thus affecting the cell migration and EMT of CRC [88]."
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