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Calcium(2+) increases the amount of USP43. 4 / 4
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"Ca v 2.2 by activating calcineurin/NFAT2 dephosphorylation modulates the deubiquinating enzyme USP43 expression that promotes invadopodia formation by stabilizing cortactin, which lead to metastasis.A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, Ca v 2.2 upregulates USP43 expression through NFAT2 dephosphorylation and nuclear localization."
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"We then investigated the regulation of USP43 by Ca 2.2 and found that knock-down of Ca 2.2 decreased USP43 expression whereas over-expression of Ca 2.2 increased USP43 expression transcriptionally and at the protein level (Fig. 7A–C)."
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"NFAT2 knock-down abolished the up-regulation of USP43 levels by Ca 2.2 (Fig. 8A, B)."
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