IndraLab

Statements


USP27X affects Cyclin_E
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USP27X activates Cyclin_E.
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"USP27 mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis."

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"XREF_FIG, catalytically inactive USP27/CA mutant failed to protect Cyclin E from degradation, implying that the DUB activity is required for USP27 mediated Cyclin E stabilization."

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"USP27 mediated Cyclin E stabilization is involved in tumorigenesis, suggesting that targeting USP27 may represent a new therapeutic strategy to treat cancers with aberrant overexpression of Cyclin E protein."

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"XREF_FIG, MG132 (proteasome inhibitor) treatment could rescue the USP27 knockdown mediated degradation of Cyclin E protein."

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"Finally, we determined whether USP27 mediated Cyclin E stability is through proteasome."

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"Our discovery that USP27 mediated Cyclin E stabilization implied that USP27 might modulate cell cycle and cell proliferation through Cyclin E regulation."
USP27X binds Cyclin_E.
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"In addition, we examined whether endogenous Cyclin E interacts with USP27 in the Hep3B cells."

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"To further confirm that the interaction between Cyclin E and USP27 was specific, we transfected them alone or together into HEK293T cells and evaluated their interaction by immunoprecipitation and WB."

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"The observation that USP27 interacts with and deubiquitinates Cyclin E led us to think that USP27 might involve in cell cycle progression by regulating Cyclin E stability."
USP27X deubiquitinates Cyclin_E.
| 2
USP27X deubiquitinates Cyclin_E. 2 / 2
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"The observation that USP27 interacts with and deubiquitinates Cyclin E led us to think that USP27 might involve in cell cycle progression by regulating Cyclin E stability."

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"First, USP27 interacts with and colocalizes with Cyclin E. Second, USP27 negatively regulates Cyclin E ubiquitination."
USP27X increases the amount of Cyclin_E.
| 1
USP27X increases the amount of Cyclin_E. 1 / 1
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"Third, USP27 positively regulates Cyclin E protein level."
USP27X affects BCL2L11
3 1 | 6 1
USP27X binds BCL2L11.
3 | 1 1
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"USP27x, acting as a tumor suppressor, could bind to Bim upon its anti-apoptotic ERK dependent phosphorylation and counteract the following proteasomal degradation via its deubiquitinase activity."

No evidence text available

No evidence text available

No evidence text available
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sparser
"Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels."
USP27X inhibits BCL2L11.
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"USP27x DUB antagonizes the Raf-ERK Bim degradation pathway thus stabilizing Bim expression."

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"Cathepsin K inhibition induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x mediated Bim protein stabilization."

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"Loss of endogenous Usp27x enhances the Bim degrading activity of oncogenic Raf."
USP27X deubiquitinates BCL2L11.
1 | 2
USP27X leads to the deubiquitination of BCL2L11. 2 / 2
1 | 1

"Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels."

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"Thus, Usp27x can trigger via its proteolytic activity the deubiquitination of Bim and enhance its levels, counteracting the anti-apoptotic effects of ERK activity, and therefore acts as a tumour suppressor."
Modified USP27X leads to the deubiquitination of BCL2L11. 1 / 1
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"Overexpression of Usp27x reduces ERK dependent Bim ubiquitination, stabilizes phosphorylated Bim, and induces apoptosis in PMA stimulated cells, as well as in tumour cells with a constitutively active Raf and ERK pathway."

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"Importantly, expression of WT, but not mutant USP27X, prevented the proliferation defects caused by depletion of endogenous USP27X (XREF_FIG)."

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"Importantly, expression of WT, but not mutant USP27X, prevented the proliferation defects caused by depletion of endogenous USP27X."

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"Expression of WT-USP27X on its own led to slightly increased proliferation, whereas expression of the C285S mutant led to slightly reduced proliferation."

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"Our data showed that USP27 promotes cell proliferation and migration."

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"The observation that USP27 promotes cell cycle progression and cell proliferation prompted us to imagine that depletion of USP27 expression might suppress tumor progression."

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"Herein, we demonstrate that USP27 regulates Cyclin E abundance to accelerate cell cycle progression, cell proliferation, and tumor cell growth as well."

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"Furthermore, cell proliferation was also remarkably reduced in the combination of USP27 knockdown and 5-FU treatment, whereas overexpression of USP27 or addition of Cyclin E in USP27 knockdown cells could raise cell proliferation."

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"Importantly, expression of WT, but not mutant USP27X, prevented the proliferation defects caused by depletion of endogenous USP27X (XREF_FIG)."

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"Importantly, expression of WT, but not mutant USP27X, prevented the proliferation defects caused by depletion of endogenous USP27X."
ATXN7L3 affects USP27X
2 | 4 2
ATXN7L3 binds USP27X.
2 | 3 2
2 | 3

No evidence text available

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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."

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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

No evidence text available

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"ATXN7L3 and ENY2 associate with USP27X and USP51."
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
ATXN7L3 deubiquitinates USP27X.
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ATXN7L3 deubiquitinates USP27X. 1 / 1
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"Our results now reveal that in addition to USP22, ATXN7L3 and ENY2 activate two previously uncharacterized deubiquitinating enzymes, USP27X and USP51, which are not part of SAGA."
USP51 affects USP27X
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USP51 binds USP27X. 4 / 4
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"The reduced tumor burden upon depletion of USP27X prompted us to search the The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenotypes."

sparser
"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( Dedio et al., 1998 )."

sparser
"Interestingly, one of the USP27X and USP51 associated proteins, C1QBP, was originally described as a mitochondrial protein ( xref )."

sparser
"The reduced tumor burden upon depletion of USP27X prompted us to search The Cancer Genome Atlas (TCGA) database to see if altered expression of USP27X or USP51 is associated with certain cancer phenot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
USP22 binds USP51 and USP27X. 1 / 1
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sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
USP27X affects ATXN7L3
2 | 3 2
2 | 3

No evidence text available

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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."

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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

No evidence text available

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"ATXN7L3 and ENY2 associate with USP27X and USP51."
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
USP22 affects USP27X
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USP22 inhibits USP27X.
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USP22 inhibits USP27X. 2 / 2
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"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5 associated proteins after shRNA mediated depletion of USP22 (XREF_FIG, lanes 2 and 3 and 5 and 6)."

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"To determine whether USP22 blocks association of USP27X and USP51 with SAGA, we isolated GCN5 associated proteins after shRNA mediated depletion of USP22."
USP22 binds USP27X.
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No evidence text available
USP22 binds USP51 and USP27X. 1 / 1
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sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
USP22 activates USP27X.
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USP22 activates USP27X. 2 / 2
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"Equal numbers of cells expressing shRNAs that specifically target USP27X or USP51, but not USP22, or expressing control shRNA, were seeded and monitored for proliferation by cell counts 72 hr later."

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"Equal numbers of cells expressing shRNAs that specifically target USP27X or USP51, but not USP22 (XREF_FIG), or expressing control shRNA, were seeded and monitored for proliferation by cell counts 72 hours later."
ENY2 affects USP27X
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ENY2 binds USP27X.
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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

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"ATXN7L3 and ENY2 associate with USP27X and USP51."

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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
ENY2 deubiquitinates USP27X.
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ENY2 deubiquitinates USP27X. 1 / 1
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"Our results now reveal that in addition to USP22, ATXN7L3 and ENY2 activate two previously uncharacterized deubiquitinating enzymes, USP27X and USP51, which are not part of SAGA."
USP27X affects cell cycle
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"We found that USP27 knockdown suppresses cell cycle progression by increasing the percentage of cells in G0/G1 phase, which can be reversed by the addition of Cyclin E expression."

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"Herein, we demonstrate that USP27 regulates Cyclin E abundance to accelerate cell cycle progression, cell proliferation, and tumor cell growth as well."

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"The observation that USP27 promotes cell cycle progression and cell proliferation prompted us to imagine that depletion of USP27 expression might suppress tumor progression."

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"To further support our notion that USP27 promotes cell cycle progression, we detected a statistically significant reduction in the growth of Hep3B and MHCC97H cells compared with that of control cells with single stable knockdown of USP27."

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"XREF_FIG, USP27 knockdown suppresses cell cycle progression by increasing the percentage of cells in G1/S phase but decreasing the percentage of cells in G2/M phase, similar to 5-FU treatment."
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"Finally, deletion of Usp27x reduces apoptosis in NSCLC cells treated with an EGFR inhibitor."

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"The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis."

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"Overexpression of Usp27x induces low levels of apoptosis in melanoma and non small cell lung cancer (NSCLC) cells and substantially enhances apoptosis induced in these cells by the inhibition of ERK signalling."
Modified USP27X activates apoptotic process. 1 / 1
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"Overexpression of Usp27x reduces ERK dependent Bim ubiquitination, stabilizes phosphorylated Bim, and induces apoptosis in PMA stimulated cells, as well as in tumour cells with a constitutively active Raf and ERK pathway."
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"In addition, in NSCLC cells, depletion of USP27x reduces apoptosis when treated with an EGFR inhibitor."
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"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."

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"Taken together, these results suggested that USP27 might promote hepatoma metastasis."

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"Although Cyclin E has been reported to involve in metastasis [XREF_BIBR], how USP27 promotes migration and metastasis also need further detailed exploration."

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"How does USP27 promote migration and metastasis?"
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"Down regulation of USP27 suppresses hepatocellular migration and metastasis."
USP27X affects ENY2
| 3 2
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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations (XREF_FIG, lanes 5 and 6)."

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"ATXN7L3 and ENY2 associate with USP27X and USP51."

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"As expected, ATXN7L3 and ENY2 associated with USP27X and USP51, but no other SAGA components, such as GCN5 or TAF10, were observed in the immunoprecipitations."
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
BCL2L11 affects USP27X
3 | 1 1
3 | 1

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"USP27x, acting as a tumor suppressor, could bind to Bim upon its anti-apoptotic ERK dependent phosphorylation and counteract the following proteasomal degradation via its deubiquitinase activity."

No evidence text available

No evidence text available

No evidence text available
| 1

sparser
"Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels."
TGFB affects USP27X
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TGFB activates USP27X. 4 / 4
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eidos
"TGFbeta also induces USP27X expression , which increases SNAI1 stability by deubiquitination [ 55 ] ."
| PMC

eidos
"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."

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"TGFbeta activated USP27X deubiquitinase regulates cell migration and chemoresistance via stabilization of Snail1."

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"USP27X was upregulated by TGFbeta during EMT and was required for TGFbeta induced expression of Snail1 and other mesenchymal markers in epithelial cells and CAF."
Cyclin_E affects USP27X
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Cyclin_E binds USP27X.
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"In addition, we examined whether endogenous Cyclin E interacts with USP27 in the Hep3B cells."

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"To further confirm that the interaction between Cyclin E and USP27 was specific, we transfected them alone or together into HEK293T cells and evaluated their interaction by immunoprecipitation and WB."

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"The observation that USP27 interacts with and deubiquitinates Cyclin E led us to think that USP27 might involve in cell cycle progression by regulating Cyclin E stability."
Cyclin_E inhibits USP27X.
| 1
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"Interestingly, USP27 expression might also be regulated by Fbxw7, a well-known E3 ubiquitin ligase of Cyclin E, which interacts with and degrades USP27."
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Valproic acid decreases the amount of USP27X.
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Valproic acid decreases the amount of USP27X. 2 / 2
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No evidence text available

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Valproic acid methylates USP27X.
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No evidence text available
USP27X affects DDX58
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USP27X ubiquitinates DDX58.
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USP27X ubiquitinates DDX58. 2 / 2
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"To the best of our knowledge, at least nine DUBs, A20, CYLD, USP3, USP5, USP14, USP15, USP21, USP25, and USP27X, have been proposed to counteract the K63linked ubiquitination of RIG-I and, thereby attenuate downstream signaling and IFN-b production ( Table 1 and Figure 3 ) (58, 76, 93) ."

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"USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I."
USP27X deubiquitinates DDX58.
| 1
USP27X leads to the deubiquitination of DDX58. 1 / 1
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"Additionally, ubiquitination assays demonstrated that USP27X reduced RIG-I ubiquitination, specifically the K63-ubiquitin linkage type."
USP27X affects CGAS
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USP27X binds CGAS.
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USP27X binds CGAS and K48. 2 / 2
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"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."

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"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
USP27X deubiquitinates CGAS.
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USP27X deubiquitinates CGAS. 1 / 1
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"Cutting Edge : USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA Mediated Signaling."
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Hsa-miR-8485 decreases the amount of USP27X. 2 / 2
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No evidence text available

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Hsa-miR-552-5p decreases the amount of USP27X. 2 / 2
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Hsa-miR-302c-5p decreases the amount of USP27X. 2 / 2
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CGAS affects USP27X
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USP27X binds cGAS. 2 / 2
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sparser
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48‐linked polyubiquitin chains during viral infection.[ 208 ] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48‐linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV‐1 stimulation.[ 209 ] Following HSV‐1 infection, USP29 knockout mice were shown to be hypersensitive to HSV‐1 and produced less type I IFNs and proinflammatory cytokines than the wildtype control."

sparser
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48‐linked polyubiquitin chains during viral infection. [ xref ] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48‐linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV‐1 stimulation. [ xref ] Following HSV‐1 infection, USP29 knockout mice were shown to be hypersensitive to HSV‐1 and produced less type I IFNs and proinflammatory cytokines than the wildtype control."
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Bisphenol A increases the amount of USP27X.
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Bisphenol A increases the amount of USP27X. 1 / 1
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No evidence text available
Bisphenol A decreases the amount of USP27X.
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Bisphenol A decreases the amount of USP27X. 1 / 1
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No evidence text available
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Benzo[a]pyrene decreases the amount of USP27X. 2 / 2
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USP51 affects USP
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USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
USP27X affects cGAS
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USP27X binds cGAS. 2 / 2
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sparser
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48‐linked polyubiquitin chains during viral infection.[ 208 ] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48‐linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV‐1 stimulation.[ 209 ] Following HSV‐1 infection, USP29 knockout mice were shown to be hypersensitive to HSV‐1 and produced less type I IFNs and proinflammatory cytokines than the wildtype control."

sparser
"Unlike USP14, USP27x directly interacts with cGAS and releases the K48‐linked polyubiquitin chains during viral infection. [ xref ] Recently, a study reported that USP29 interacts with cGAS, hydrolyzes K48‐linked polyubiquitin chains on cGAS, and stabilizes cGAS in uninfected cells, or after HSV‐1 stimulation. [ xref ] Following HSV‐1 infection, USP29 knockout mice were shown to be hypersensitive to HSV‐1 and produced less type I IFNs and proinflammatory cytokines than the wildtype control."
USP27X affects USP22
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No evidence text available
USP22 binds USP51 and USP27X. 1 / 1
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sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
USP27X affects USP
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USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."

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"USP27X modulates tumor chemoresistance and invasion through deubiquitination and stabilization of Snail1 XREF_BIBR."

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"Conversely, overexpression of USP27 evidently enhanced cell invasion."
USP27X affects K48
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USP27X binds CGAS and K48. 2 / 2
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"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."

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"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
| 2
USP27X deubiquitinates Histone_H2B. 2 / 2
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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that the ATXN7L3 zinc finger plays a role analogous to that of the Sgf11 zinc finger in docking human SAGA DUB [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The requirement of ATXN7L3 for H2B deubiquitination by USP22, USP27x, and USP51 suggests that all three use the ATXN7L3 zinc finger to dock the H2A and H2B acidic patch in a manner similar to that shown in the structure of the yeast DUB module bound to ubiquitinated nucleosomes."
USP27X affects H2Aub1
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USP27X deubiquitinates H2Aub1. 2 / 2
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"As was previously shown for the USP22 DUBm, both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1 (XREF_FIG and XREF_SUPPLEMENTARY)."

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"As was previously shown for the USP22 DUBm (Zhang et al., 2008a; Zhao et al., 2008), both USP27X and USP51 DUBm also deubiquitinated nucleosomal or free H2Aub1."
USP affects USP51
| 2
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
K48 affects USP27X
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USP27X binds CGAS and K48. 2 / 2
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"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."

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"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
ENY2 affects USP51
| 2
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
EGFR inhibitor affects USP27X
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EGFR inhibitor inhibits USP27X.
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EGFR inhibitor inhibits USP27X. 1 / 1
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"Finally, deletion of Usp27x reduces apoptosis in NSCLC cells treated with an EGFR inhibitor."
EGFR inhibitor activates USP27X.
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EGFR inhibitor activates USP27X. 1 / 1
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"In addition, in NSCLC cells, depletion of USP27x reduces apoptosis when treated with an EGFR inhibitor."
CGAS affects USP27X
| 2
USP27X binds CGAS and K48. 2 / 2
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"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."

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"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."
ATXN7L3 affects USP51
| 2
USP27X binds USP51, ENY2, ATXN7L3, and USP. 2 / 2
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sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ 47 • ]."

sparser
"A recent study showed that ATXN7L3 and ENY2 can also form complexes with two additional USP DUBs, USP27x and USP51, and target them to H2B-Ub [ xref ]."
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"In our study, we found that both USP27 and Cyclin E are downregulated by 5-FU treatment in a dose dependent manner."
5-formyluracil decreases the amount of USP27X.
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5-formyluracil decreases the amount of USP27X. 1 / 1
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"Anti-cancer drug 5-FU regulates cell cycle progression and inhibits hepatocellular proliferation by downregulating USP27 expression."
Urethane affects USP27X
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Urethane decreases the amount of USP27X. 1 / 1
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No evidence text available
Superoxide affects USP27X
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"Down-regulation of Raptor expression increased mitochondrial ROS production, and mitochondria specific superoxide scavengers prevented USP27x mediated stabilization of Bim by inhibition of Cat K. Moreover, combined treatment with Cat K inhibitor (odanacatib) and tumor necrosis factor related apoptosis inducing ligand (TRAIL) reduced tumor growth and induced cell death in a xenograft model."
Sunitinib affects USP27X
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Sunitinib decreases the amount of USP27X. 1 / 1
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No evidence text available
Silver(0) affects USP27X
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Silver(0) decreases the amount of USP27X. 1 / 1
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No evidence text available
Proteasome inhibitor affects USP27X
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Proteasome inhibitor activates USP27X. 1 / 1
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reach
"XREF_FIG, MG132 (proteasome inhibitor) treatment could rescue the USP27 knockdown mediated degradation of Cyclin E protein."
Potassium dichromate increases the amount of USP27X. 1 / 1
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No evidence text available
Jinfukang affects USP27X
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Jinfukang increases the amount of USP27X. 1 / 1
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No evidence text available
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Hsa-miR-603 decreases the amount of USP27X. 1 / 1
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No evidence text available
Dieldrin affects USP27X
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Dieldrin increases the amount of USP27X. 1 / 1
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No evidence text available
Dibutyl phthalate decreases the amount of USP27X. 1 / 1
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No evidence text available
Cisplatin affects USP27X
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Cisplatin increases the amount of USP27X. 1 / 1
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No evidence text available
USP51 affects USP22
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USP22 binds USP51 and USP27X. 1 / 1
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sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."

eidos
"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
USP27X affects cisplatin
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"USP27X depletion impaired Snail1 dependent cell migration and invasion and metastasis formation and increased cellular sensitivity to cisplatin."
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"As shown in Figure S5A-D, depletion of USP27 expression significantly decreased cell migration compared with the control in Hep3B and MHCC97H cells using wound healing assay."
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"Herein, we demonstrate that USP27 regulates Cyclin E abundance to accelerate cell cycle progression, cell proliferation, and tumor cell growth as well."

reach
"Knockdown of Usp22 shortened the half-life of Hes1, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis expression of Usp27x reduced neuronal differentiation."
USP27X affects Ubiquitin
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"In the past year, two other deubiquitinating enzymes, USP27X and USP1, have been reported to impede ubiquitin mediated degradation of Snail1 in various biological contexts XREF_BIBR, XREF_BIBR."
USP27X affects UBC
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No evidence text available
USP27X affects Snail1
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USP27X deubiquitinates Snail1. 1 / 1
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"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [XREF_BIBR]."
USP27X affects Snail1 protein
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USP27X inhibits Snail1 protein. 1 / 1
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"Accordingly, downregulation of USP27X decreased Snail1 protein in several tumor cell lines."
USP27X affects SNAI1 stability
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USP27X activates SNAI1 stability. 1 / 1
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eidos
"TGFbeta also induces USP27X expression , which increases SNAI1 stability by deubiquitination [ 55 ] ."
| PMC
USP27X affects SH3KBP1
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No evidence text available
USP27X affects RNF168
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USP27X activates RNF168. 1 / 1
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"Interestingly, the DUBs USP26 and USP27 were found to modulate RNF168 mediated protein ubiquitylation at DSB sites, preventing excessive spreading of RAP80-BRCA1, promoting association of BRCA1 with P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP27X affects RIG-I ubiquitination
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USP27X inhibits RIG-I ubiquitination. 1 / 1
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eidos
"Additionally , ubiquitination assays demonstrated that USP27X reduced RIG-I ubiquitination , specifically the K63-ubiquitin linkage type ."
USP27X affects RAF
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USP27X inhibits RAF. 1 / 1
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"Loss of endogenous Usp27x enhances the Bim degrading activity of oncogenic Raf."
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reach
"Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619."
USP27X affects KLHL20
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No evidence text available
USP27X affects Interferon
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"Among the DUBs that interact with cGAS or MDA5, USP27X (98) and USP29 (99) stabilize cGAS and thus positively regulate IFN production and antiviral activities."
USP27X affects HES1
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USP27X deubiquitinates HES1. 1 / 1
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"Knockdown of Usp22 shortened the half-life of Hes1, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis-expression of Usp27x reduced neuronal differentiation."
USP27X affects H2Bub1
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USP27X activates H2Bub1. 1 / 1
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"Taken together with previous findings by others that USP22 is overexpressed in many cancers and our findings that ATXN7L3 and ENY2 levels are normally limiting in cells, these results suggest that imb[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP27X affects H2BC10
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USP27X deubiquitinates H2BC10. 1 / 1
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"In contrast, depletion of non-enzymatic components, ATXN7L3 or ENY2, results in increased H2Bub1. These observations led us to discover two H2Bub1 DUBs, USP27X and USP51, which function independently of SAGA and compete with USP22 for ATXN7L3 and ENY2 for activity."
USP27X affects GATD3B
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USP27X deubiquitinates GATD3B. 1 / 1
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reach
"We found that Hes1 was deubiquitinated and stabilized by Usp27x and its homologs ubiquitin specific protease 22 (Usp22) and ubiquitin specific protease 51 (Usp51)."
USP27X affects ERK
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sparser
"Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels."
USP22 affects USP51
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USP22 binds USP51 and USP27X. 1 / 1
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sparser
"Due to the lack of ChIP grade antibodies, we have not yet been able to define loci directly bound by USP27X, USP51, or USP22, so we cannot specify genes and pathways directly governed by these DUBs."
UBC affects USP27X
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No evidence text available
Soman affects USP27X
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Soman increases the amount of USP27X. 1 / 1
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No evidence text available
SH3KBP1 affects USP27X
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No evidence text available
N-methyl-4-phenylpyridinium increases the amount of USP27X. 1 / 1
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No evidence text available
KLHL20 affects USP27X
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No evidence text available
ERK affects USP27X
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sparser
"Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels."
CAT affects USP27X
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CAT decreases the amount of USP27X. 1 / 1
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"Inhibition of Cat K increased USP27x expression, and knock down of USP27x markedly blocked Cat K induced up-regulation of Bim expression."
BCL2L11 affects ERK, and USP27X
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sparser
"Here, we report the identification of a deubiquitinase, Usp27x, that binds Bim upon its ERK-dependent phosphorylation and can upregulate its expression levels."
1 |

No evidence text available