IndraLab

Statements

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"How does USP27 promote migration and metastasis?"
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"Although Cyclin E has been reported to involve in metastasis [XREF_BIBR], how USP27 promotes migration and metastasis also need further detailed exploration."
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"USP27X promotes the proliferation, invasion, and metastasis of BC cells by up-regulating CBX2."
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"Knockdown of USP27X was found to decrease the incidence of lung metastases from BC cells, while overexpression of USP27X had the opposite effect (Fig. 4L)."
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"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
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"Instead, overexpression of USP27X‐AS1 increased tumour burden, PCNA and liver metastasis nodules (each group n = 7) (Figure 3G–K)."
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"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
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"In vivo studies confirmed that USP27 knockdown suppresses HCC growth and metastasis."
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"Taken together, these results suggested that USP27 might promote hepatoma metastasis."
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