IndraLab

Statements

USP27X activates apoptotic process. 5 / 5
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"The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis."
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"Finally, deletion of Usp27x reduces apoptosis in NSCLC cells treated with an EGFR inhibitor."
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"However, the authors also found that overexpression of USP27x combined with ERK1/2 pathway inhibition to promote apoptosis."
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"Overexpression of Usp27x induces low levels of apoptosis in melanoma and non small cell lung cancer (NSCLC) cells and substantially enhances apoptosis induced in these cells by the inhibition of ERK signalling."
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"Overexpression of USP27x combined with ERK1/2 activation to promote the deubiquitylation and stabilisation of BIM and increase caspase‐dependent apoptosis."
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