IndraLab

Statements

USP27X activates SETD3. 4 / 4
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"Inhibition of USP27 expression impairs the pro-migratory ability of SETD3."
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"Since upregulation of SETD3 can promote liver tumorigenesis and cancer progression [12], it is possible that USP27 can also enhance metastatic phenotype by stabilizing SETD3."
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"Knockdown of USP27 by short hairpin RNA (shRNA) accelerated the degradation of SETD3 and blocked cell proliferation."
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"In conclusion, our data suggested that USP27 could positively regulate SETD3 protein stability."
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