IndraLab

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USP27X deubiquitinates HES1. 4 / 4
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"Another study demonstrated that USP27x, Usp22, and Usp51 deubiquitinate and stabilize Hes1 protein, a transcriptional repressor necessary for the maintenance of neural stem/progenitor cells."
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"We found that Hes1 was deubiquitinated and stabilized by Usp27x and its homologs ubiquitin specific protease 22 (Usp22) and ubiquitin specific protease 51 (Usp51)."
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"Knockdown of Usp22 shortened the half-life of <span class="match term1">Hes1</span>, delayed its oscillation, and enhanced neuronal differentiation in mouse developing brain, whereas mis-expression of <span class="match term0">Usp27x</span> reduced neuronal differentiation."
25846153
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"In addition, USP27 could regulate neuronal differentiation of stem cells in the developing mouse neocortex by deubiquitinating and stabilizing Hes1 [22]."
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