IndraLab

Statements

USP27X binds CCND1. 7 / 7
1 | 6
reach
"USP27X interacts with and stabilizes CCND1."
36001804
reach
"USP27X binds to and stabilizes CCND1 in a catalytically-dependent manner by negatively regulating its ubiquitination."
36001804
reach
"Here, we demonstrate that USP27X interacts with and stabilizes the proto-oncogene CCND1."
36001804
biogrid
No evidence text available
36001804
reach
"As USP27X would need to physically interact with CCND1 in order to stabilize it, we next tested whether USP27X binds CCND1."
36001804
reach
"Not only does USP27X bind to CCND1, but USP27X catalytic activity is required for reduction of CCND1 ubiquitination levels and protein stability independent of phosphorylation in cancer cells."
36001804
reach
"Future studies will elucidate at what stage and in which cellular compartment USP27X interacts with and stabilizes CCND1 and whether additional cofactors or posttranslational modifications are required to facilitate its activity toward this protein."
36001804