IndraLab

Statements

USP27X deubiquitinates SNAI1. 5 / 5
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"USP27X promotes EMT progression in tumors by deubiquitinating and stabilizing Snail1 [41]."
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"Another deubiquitinase, USP27X, which was activated by TGFβ, could also deubiquitinate SNAIL1."
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"USP27X contributes to Snail1 deubiquitination and stabilization, and transforming growth factor-β (TGF-β) is able to promote EMT by upregulating USP27X (Lambies et al., 2019)."
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"3) Does USP27X require specific cofactors to deubiquitinate Snail1?"
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"Here, we performed an siRNA screen and identified <span class="match term0">USP27X</span> as a deubiquitinase that increases <span class="match term1">Snail1</span> stability"
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