IndraLab

Statements

USP27X inhibits BCL2L11. 3 / 3
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"These data suggested that Raptor downregulation-mediated mitochondrial ROS production is critical for the enhancement of ODN-induced anti-cancer drugs sensitivity via USP27x-mediated Bim stabilization.3.7 Combined treatment with ODN and TRAIL reduces tumor growth in vivo."
31901727
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"USP27x DUB antagonizes the Raf-ERK Bim degradation pathway thus stabilizing Bim expression."
29479529
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"Loss of endogenous Usp27x enhances the Bim degrading activity of oncogenic Raf."
27013495