IndraLab

Statements

USP27X deubiquitinates BCL2L11. 7 / 8
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"Furthermore, KD of USP27x blocked ODN-induced Bim expression and deubiquitination of Bim (Fig. 4G and H)."
31901727
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"Overexpression of USP27x combined with ERK1/2 activation to promote the deubiquitylation and stabilisation of BIM and increase caspase‐dependent apoptosis."
28548464
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"Thus, Usp27x can trigger via its proteolytic activity the deubiquitination of Bim and enhance its levels, counteracting the anti-apoptotic effects of ERK activity, and therefore acts as a tumour suppressor."
27013495
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"In addition, ODN dramatically inhibited ubiquitination of Bim, but KD of USP27x blocked ODN-induced deubiquitination of Bim (Fig. 4H)."
31901727
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"Moreover, USP27 deubiquitinates and stabilizes the BH3-only protein Bim, subsequently enhancing apoptosis [14]."
35018513
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"For example, Weber et al. found that wild-type USP27 can reduce the levels of Bim ubiquitination and stabilize Bim in response to the Raf‐ERK‐degradation signal [14]."
35018513
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"Overexpression of USP27x reduced ERK-dependent BIM phosphorylation and ubiquitination in PMA-stimulated cells as well as tumor cells with a constitutively active Raf/ERK pathway."
37584295