IndraLab

Statements

USP27X binds TRIM28. 5 / 5
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"At endogenous levels, the interaction between Usp27x L and TRIM28 was detected in 293FT cells (Fig.  xref D), but not in WM1158 cells (data not shown), which express substantially less Usp27x L compared to 293FT cells (Fig.  xref B)."
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"Usp27x interacts with the E3-ubiquitin ligase TRIM28, and TRIM28 deficiency blocks Usp27x-induced loss of cFLIP L level and apoptosis induction by pIC."
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"Instead, Usp27x interacted with the E3-ligase TRIM28 and reduced ubiquitination of TRIM28."
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"We also could not detect an interaction between endogenous Usp27x and TRIM28 in WM1158 cells (data not shown), and Usp27x-deficient WM1158 cells were not protected from pIC-induced apoptotic cell death (Fig.  xref E)."
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"However, in 293FT, which express substantially more Usp27x L (Fig.  xref B), the interaction between endogenous Usp27x and TRIM28 could be observed by IP (Fig.  xref D)."
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