IndraLab

Statements

USP27X inhibits cell growth. 3 / 3
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"Ablation of USP27X leads to enhanced CCND1 ubiquitination, a drastic reduction in CCND1 protein levels, and abrogated cell growth in several cancer cell lines, including HER2 therapy resistant breast cancer cells and xenograft tumors."
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"These experiments confirmed that ablation of USP27X strongly impairs cell growth, whereas ATXN7L3 depletion has no impact (Supplementary Fig. 1)."
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"As shown in Figures 5I, J, L and M, expression of WT USP27X led to a significant increase in colony number, while expression of the catalytically inactive DUB suppressed cell growth in both lines."
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