IndraLab

Statements

PLEC inhibits USP27X. 3 / 3
| 3
sparser
"In addition, the finding that hD1 inhibits USP27x alone as well as the USP27x/ENY2/ATXN7L3 complex suggest that hD1 inhibits DUB activity by binding directly to the catalytic domain, rather than to the ENY2 and ATXN7L3 subunits."
34936860
sparser
"As shown in xref , hD1 inhibits the USP27x complex at >25-fold higher inhibitor concentrations and modestly inhibits the USP51 complex only at >2500-fold higher concentration than that needed to inhibit the human DUB module."
34936860
sparser
"Since hD1 inhibits USP27x whether or not it is in complex with the other SAGA subunits, the inhibitor likely binds directly to the catalytic USP domain."
34936860