IndraLab

Statements

USP27X activates HYCC1. 8 / 8
| 8
reach
"We also found that the levels of SETD3 and USP27 increased significantly in HCC than those in the relevant adjacent tissues."
35018513
reach
"These results indicate that depletion of USP27 also inhibited HCC cell growth in vivo."
35018513
reach
"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513
reach
"USP27 knockdown inhibits HCC cell growth in vivo."
35018513
reach
"In vivo studies confirmed that USP27 knockdown suppresses HCC growth and metastasis."
39746496
reach
"In conclusion, USP27X‐AS1 upregulated AKT protein expression by recruiting USP7 to deubiquitinate AKT.3.6 USP27X-AS1 promoted HCC progression by regulating AKT."
38279869
reach
"To verify whether USP27X‐AS1 promoted HCC progression via AKT, we transfected Flag‐AKT into USP27X‐AS1 knockdown cells and used AKT‐siRNA to interfere with AKT expression in USP27X‐AS1 overexpressed cells."
38279869
reach
"To unravel the mechanism by which USP27X‐AS1 promotes HCC, we conducted RNA‐seq on HLF cells with USP27X‐AS1 overexpression and the control counterparts."
38279869