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USP27X binds CGAS and K48. 3 / 3

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"Furthermore, the deubiquitinating enzyme USP27X associates with cGAS and eliminates K48-linked polyubiquitinated chains from cGAS, leading to the stability of cGAS (24)."

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"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."

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"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."

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IndraLab

Statements

USP27X binds CGAS and K48. 3 / 3

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