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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP27X binds CGAS and K48. 2 / 2

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"In this study, we identified that deubiquitinase USP27X could interact with cGAS and cleave K48 linked polyubiquitination chains from cGAS, leading to cGAS stabilization."

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"Unlike USP14, USP27x directly interacts with cGAS and releases the K48 linked polyubiquitin chains during viral infection."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...