IndraLab

Statements

reach
"USP27X contributes to Snail1 deubiquitination and stabilization, and transforming growth factor-β (TGF-β) is able to promote EMT by upregulating USP27X (Lambies et al., 2019)."
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"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
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"Depletion of USP27X inhibited TGF-β-induced EMT and fibroblast activation, which is consistent with this [ 71 ]."
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"The inhibition of USP27X leads to Snail1 destabilization, suppresses EMT and renders tumor cells sensitive to chemotherapy (75)."
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