IndraLab

Statements

TGFB activates USP27X. 7 / 7
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"USP27X was upregulated by TGFbeta during EMT and was required for TGFbeta induced expression of Snail1 and other mesenchymal markers in epithelial cells and CAF."
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"TGFbeta enhances USP27X expression that deubiquitinates and stabilizes Snail1 , which in turn induces EMT in cancer cells and activation of CAFs ."
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"TGFbeta also induces USP27X expression , which increases SNAI1 stability by deubiquitination [ 55 ] ."
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"In fact, DUBs involved in Snail regulation so far are shown to be induced differently, while USP27x is induced by TGF-β; DUB3/USP17L2 seems to play a role in CDK4/6-mediated activation of EMT, whereas OTUB1 is under the transcriptional regulation of oestrogen-related receptor alpha, and USP37 regulation is induced during EMT via the stimulation of the hedgehog signalling pathway."
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"USP27X can also deubiquitinate and stabilize Snail1 when induced by TGF-beta and therefore promotes EMT and tumor metastasis [ 53 ] ."
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"TGFbeta activated USP27X deubiquitinase regulates cell migration and chemoresistance via stabilization of Snail1."
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"TGF-β upregulated USP27X during EMT, and it was essential for Snail1 and other mesenchymal markers to be expressed in epithelial cells and CAF."
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