IndraLab

Statements

USP27X deubiquitinates CGAS. 3 / 3
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"Guo et al. have reported that cGAS can be deubiquitinated by USP27X, thereby promoting the stability of cGAS protein and increasing cGAMP expression [22] ."
37478666
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"Cutting Edge : USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA Mediated Signaling."
31534008
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"USP27X and USP29 have a similar mechanism for the deubiquitination of cGAS, both preventing the degradation of cGAS via the proteasomal pathway by removing the K48-linked ubiquitin chain of cGAS and maintaining cGAS protein levels."
36579404