IndraLab

Statements

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"Upregulation of USP27 in hepatocellular carcinoma patients leads to elevated SETD3 expression and increased cell proliferation, invasion, migration and tumorigenesis."
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"USP27X modulates tumor chemoresistance and invasion through deubiquitination and stabilization of Snail1 XREF_BIBR."
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"Taken together, these data revealed that knockdown of USP27 or SETD3 prevents liver cancer cell migration and invasion."
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"Conversely, overexpression of USP27 evidently enhanced cell invasion."
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"Furthermore, evidence from in vitro and in vivo studies revealed that depletion of USP27 inhibited HCC cell proliferation, invasion, metastasis and tumorigenesis, and that overexpression of SETD3 rescued this phenotype."
35018513