IndraLab

Statements

USP25 affects TRAF6
1 | 15
USP25 deubiquitinates TRAF6. 10 / 13
1 | 12
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"Act1 mediated K63 linked ubiquitination of TRAF6 was inhibited by overexpression of USP25, but not USP25 (C178S) in 293T cells or in an in vitro deubiquitination system (XREF_FIG and XREF_SUPPLEMENTARY)."
23042150
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"Therefore, USP25 may indirectly lead to deubiquitination of TRAF5 or TRAF6 through its tightly associated proteins."
23042150
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"However, Zhong et al. 's study using HEK293T cells supported deubiquitination of TRAF6 by USP25 [XREF_BIBR]."
31208841
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"Similarly, Usp25 deubiquitinates both TRAF5 and TRAF6 and thereby restricts downstream gene expression."
28254169
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"Mechanistically, USP25 deubiquitinated retinoic acid inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor mediated IFN signaling."
24260525
ubibrowser
"Mechanistically, stimulation with IL-17 induced the association of USP25 with the adaptors TRAF5 and TRAF6, and USP25 induced removal of Lys63-linked ubiquitination in TRAF5 and TRAF6 mediated by the adaptor Act2."
23042150
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"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
24260525
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"Taken together, our results demonstrate that USP25 negatively regulates IL-17-triggered ubiquitination of TRAF6 and TRAF5."
23042150
reach
"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [XREF_BIBR]."
31208841
reach
"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [23]."
31208841
Modified USP25 leads to the deubiquitination of TRAF6. 2 / 2
| 2
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"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (XREF_FIG), TRAF2 (XREF_FIG), and TRAF6 (XREF_FIG)."
24260525
reach
"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (Figure 7B), TRAF2 (Figure 7D), and TRAF6 (Figure 7E)."
24260525
USP25-C178S leads to the deubiquitination of TRAF6. 1 / 1
| 1
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"Act1 mediated K63 linked ubiquitination of TRAF6 was inhibited by overexpression of USP25, but not USP25 (C178S) in 293T cells or in an in vitro deubiquitination system (XREF_FIG and XREF_SUPPLEMENTARY)."
23042150
USP25 affects DDX58
| 16
USP25 deubiquitinates DDX58. 10 / 11
| 11
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"USP21 deubiquitinated RIG-I in HEK293 T cells [24]."
31208841
reach
"Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling."
24260525
reach
"USP21 binds to and deubiquitinates RIG-I."
24493797
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"USP17 and USP25 also deubiquitinate RIG-I in a different manner; that is, USP17 stabilizes RIG-I by K48-deubiquitination, while USP25 inhibits RIG-I degradation by K63-deubiquitination [37, 38] ."
33922750
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"RNA virus induced RIG-1 can be deubiquitinated by USP21 14."
29706623
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"Therefore, it is highly likely that USP21 acts as a RIG-I polyubiquitination guard to prevent extensive RIG-I polyubiquitination."
24493797
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"In antiviral responses, USP21 binds to and deubiquitinates RIG-I in the cytoplasm to exert an immunomodulatory effect; USP21 can also hydrolyzes the K27/63 linked polyubiquitin chain on STING to negatively regulate DNA virus induced type I interferon production [XREF_BIBR]."
33628844
reach
"We reasoned that USP21 might deubiquitinate RIG-I to inhibit virus induced IRF3 activation."
24493797
reach
"USP21 was also reported to antagonize the ubiquitination of anti-viral sensor RIG-I, implicating USP21 as a negative regulator of type-I interferon production and anti-viral immunity (Fan et al., 2014[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
reach
"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
24260525
Modified USP25 leads to the deubiquitination of DDX58. 5 / 5
| 5
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"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (XREF_FIG), TRAF2 (XREF_FIG), and TRAF6 (XREF_FIG)."
24260525
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"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (Figure 7B), TRAF2 (Figure 7D), and TRAF6 (Figure 7E)."
24260525
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"Overexpression of USP21 inhibited RNA virus induced RIG-I polyubiquitination and RIG-I-mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-alpha and beta production, and antiviral responses in MEFs in response to RNA virus infection."
24493797
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"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (Figure Figure 7E )."
24260525
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"We further examined the role of USP21 in the inhibition of SeV induced RIG-I polyubiquitination and found that overexpression of USP21 WT but not C221A mutant inhibited SeV induced polyubiquitination of both FLAG tagged and endogenous RIG-I (XREF_FIG)."
24493797
USP25 affects NANOG
| 15
USP25 deubiquitinates NANOG. 10 / 15
| 15
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"Since USP21 is a DUB, we examined whether USP21 could directly interact with and deubiquitinate Nanog."
27886188
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"USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency."
29263902
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"USP21 directly interacts with and deubiquitinates Nanog."
27886188
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"USP21 deubiquitylates the K48-type linkage of the ubiquitin chain of Nanog, stabilizing Nanog."
29263902
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"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
30891497
reach
"Considering that USP21 deubiquitylates Nanog, we sought to examine the functional roles of USP21 in mESCs."
29263902
reach
"Next, we examined whether USP21 could deubiquitinate Nanog."
27886188
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"Collectively, these data suggest that USP21 can deubiquitylate and stabilize Nanog."
29263902
reach
"USP21 deubiquitylates Nanog."
29263902
reach
"Recently, three groups independently identified ubiquitin specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein."
29263917
USP25 affects RIPK1
| 8
USP25 deubiquitinates RIPK1. 8 / 8
| 8
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"USP21 interacts with RIP1 and deubiquitinates RIP1 in a DUB dependent manner."
22435550
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"Ubv.21.4 CDelta2 coimmunoprecipitated with USP21 in cotrans fected human embryonic kidney (HEK) 293T cells (XREF_FIG), blocked the deubiquitination of RIP1 by USP21 (XREF_FIG), and restored NF-kappaB activation (XREF_FIG)."
23287719
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"For example, Junichiro et al. demonstrated that USP21 constitutively deubiquitinates RIP1 in vitro and in vivo [40]; and a previous study has reported that USP20 deubiquitinates TRAF6 and Tax in vivo [40]."
24260525
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"USP21 is constitutively associated with RIP1 and deubiquitinates RIP1 in vitro and in vivo."
19910467
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"A previous study showed that USP21 deubiquitylates receptor interacting protein 1, a suppressor of TNF induced NF-KB activation."
28969054
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"Ubv.21.4 blocked the deubiquitination of RIP1 by USP21 and restored NF-jB activation, showing that it acts as an inhibitor of USP21 in cells."
24239534
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"Ubv.21.4 blocked the deubiquitination of RIP1 by USP21 and restored NF‐κB activation, showing that it acts as an inhibitor of USP21 in cells."
24239534
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"Ubv.21.4 blocked the deubiquitination of RIP1 by USP21 and restored NF‐κB activation, showing that it acts as an inhibitor of USP21 in cells."
24239534
USP25 affects YY1
| 7
USP25 deubiquitinates YY1. 7 / 7
| 7
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"Hence, SNHG16 competitively bound to miR-4500 to regulate the expression of USP21.In the current study, we showed that oncogenic USP21 deubiquitinates and stabilizes YY1 and that YY1 transcriptionally activates lncRNA SNHG16, which further acts as a ceRNA to regulate USP21 (Fig. 8)."
31956270
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"However, the function of these networks and their mechanisms upstream and downstream in association with the pathogenesis of NSCLC remain poorly understood.Our current study, for the first time, reported that USP21 acted as an oncogene by deubiquitinating YY1 to stabilize its protein levels in NSCLC cells."
31956270
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"Because USP21 is a DUB, we examined whether USP21 could directly interact with and deubiquitinate YY1."
31956270
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"The high-molecular-weight conjugates observed were then purified and subjected to blotting for YY1, and the blots demonstrated that wt USP21 but not USP21 C221A reduced YY1 ubiquitination (Fig. 5g)."
31956270
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"USP21 deubiquitinates YY1 in LC cells."
31956270
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"We observed that USP21 deubiquitinated YY1 and thus stabilized it."
31956270
reach
"Collectively, these findings suggest that USP21 deubiquitinates YY1 in LC cells."
31956270
USP25 affects TRAF5
1 | 6
USP25 deubiquitinates TRAF5. 7 / 7
1 | 6
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"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [XREF_BIBR]."
31208841
reach
"Therefore, USP25 may indirectly lead to deubiquitination of TRAF5 or TRAF6 through its tightly associated proteins."
23042150
reach
"We found that Act1 mediated K63 linked ubiquitination of TRAF5 (XREF_SUPPLEMENTARY), which was substantially attenuated by USP25 but not USP25 (C178S) in 293T cells or in an in vitro deubiquitination system (XREF_FIG and XREF_SUPPLEMENTARY)."
23042150
reach
"Taken together, our results demonstrate that USP25 negatively regulates IL-17-triggered ubiquitination of TRAF6 and TRAF5."
23042150
reach
"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [23]."
31208841
ubibrowser
"Mechanistically, stimulation with IL-17 induced the association of USP25 with the adaptors TRAF5 and TRAF6, and USP25 induced removal of Lys63-linked ubiquitination in TRAF5 and TRAF6 mediated by the adaptor Act1."
23042150
reach
"Similarly, Usp25 deubiquitinates both TRAF5 and TRAF6 and thereby restricts downstream gene expression."
28254169
USP25 affects TRAF3
1 | 5
USP25 deubiquitinates TRAF3. 5 / 5
1 | 4
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"Taking it one step further, Lin et al. uncovered that USP25 stabilizes TRAF3 in a DUB activity dependent manner by deubiquitinating K48-Ub of TRAF3 in bone marrow-derived macrophages (BMDM) cells, inhibiting TLR4 signaling-induced innate immune responses [21]."
31208841
reach
"We mentioned in a previous section that USP25 deubiquitinates TRAF3 and interacts with TRAF6, increasing expression of Tnf in HEK293 T cells [21,22], while in MEF cells, USP25 negatively affects TNF-α-induced NF-κB activation [20]."
31208841
reach
"Because the activation of TLR4 results in the K 48 -linked ubiquitination and degradation of TRAF3, we next determined the effects of a deficiency in USP25 on the LPS induced ubiquitination and degradation of TRAF3."
23674823
reach
"We mentioned in a previous section that USP25 deubiquitinates TRAF3 and interacts with TRAF6, increasing expression of Tnf in HEK293T cells [XREF_BIBR, XREF_BIBR], while in MEF cells, USP25 negatively affects TNF-alpha-induced NF-kappaB activation [XREF_BIBR]."
31208841
ubibrowser
"Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3"
23674823
Modified USP25 leads to the deubiquitination of TRAF3. 1 / 1
| 1
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"USP25 expression indeed decreased TRAF3 polyubiquitination (XREF_FIG, lane 3)."
27026194
USP25 affects TRAF2
| 5
USP25 deubiquitinates TRAF2. 3 / 3
| 3
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"Mechanistically, USP25 deubiquitinated retinoic acid inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor mediated IFN signaling."
24260525
reach
"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
24260525
reach
"USP25 deubiquitinates RIG-I, TRAF2 and TRAF6."
24260525
Modified USP25 leads to the deubiquitination of TRAF2. 2 / 2
| 2
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"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (Figure 7B), TRAF2 (Figure 7D), and TRAF6 (Figure 7E)."
24260525
reach
"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (XREF_FIG), TRAF2 (XREF_FIG), and TRAF6 (XREF_FIG)."
24260525
USP25 affects MAP2K2
| 5
USP25 deubiquitinates MAP2K2. 5 / 5
| 5
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"Conversely, USP21 inhibition increased MEK2 ubiquitylation in cells."
29706623
reach
"XREF_FIG, wild type USP21 decreased MEK2 ubiquitination, whereas the C221A USP21 deubiquitinase deficient mutant failed to do so."
29706623
reach
"USP21 deubiquitinates and stabilizes MEK2, which contributes to tumorigenesis ."
31956270
reach
"Since USP21 functions as a deubiquitylase, we next ask whether USP21 deubiquitylates MEK2."
29706623
reach
"USP21 deubiquitylates MEK2."
29706623
USP25 affects EZH2
| 5
USP25 deubiquitinates EZH2. 5 / 5
| 5
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"As EZH2 has been reported to promote cell metastasis in BC, our work identified that USP21 deubiquitinated EZH2 and stabilized it."
28223825
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"45 USP21 could suppress EZH2 ubiquitination and thus promotes cell proliferation and metastasis in bladder carcinoma."
33389794
reach
"USP21 can deubiquitinate and stabilize EZH2 to induce cell proliferation and metastasis of bladder cancer (150)."
35445731
reach
"Chen Y. et al identify that USP21 can deubiquitinate and stabilize EZH2 to promote cell proliferation and metastasis in bladder carcinoma (31); Zhang P. et al find that ZRANB1 is an EZH2 deubiquitinase and regulates EZH2 function in breast cancer through both catalytic activity-dependent and -independent manner (32)."
30425057
reach
"Ubiquitin specific protease (USP21) deubiquitinates EZH2 and stabilizes it."
30150556
USP25 affects BRCA2
| 5
USP25 deubiquitinates BRCA2. 5 / 5
| 5
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"We now show that USP21 interacts with and deubiquitinates BRCA2 and that USP21 loss results in decreased BRCA2 expression in tumor cell lines."
28743957
reach
"USP21 interacts with and deubiquitinates BRCA2."
28743957
reach
"USP4, for example, interacts directly with end resection factors CtIP and MRN [172], USP21 deubiquitinates and stabilizes BRCA2 to promote RAD51 binding and successful HR [173], and USP10 deubiquitinates and stabilizes p53 to promote its nuclear localization and apoptosis in response to DSBs [174]."
32708614
reach
"To determine whether USP21 is sufficient to deubiquitinate BRCA2 fragments, we performed in vitro deubiquitination assays using HA ubiquitinated, immuno purified BRCA2 fragments as well as full-length Flag-BRCA2."
28743957
reach
"To determine whether USP21 can promote the deubiquitination of endogenous BRCA2 and/or the BRCA2 associated RAD51 and PALB2 proteins XREF_BIBR, XREF_BIBR, we measured the extent of (poly-) ubiquitin modifications on either protein in the presence or absence of USP21 overexpression."
28743957
USP25 affects RPS20
| 4
USP25 deubiquitinates RPS20. 4 / 4
| 4
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"Taken together, these results indicate that USP21 or OTUD3 can deubiquitylate both eS10 and uS10, resulting in enhanced readthrough of poly(A)-mediated stall events."
32011234
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"USP21 and OTUD3 antagonize the ubiquitination of eS10 and uS10 that results from integrated stress response (ISR) and ribosome-associated quality control pathway (RQC) (124)."
34391779
reach
"Exogenous expression of USP21 substantially reduced the ZNF598-stimulated eS10 and uS10 ubiquitylation in an activity-dependent manner (Figure 3E)."
32011234
reach
"USP21 and OTUD3 deubiquitylate ZNF598 substrates eS10 and uS10."
32011234
USP25 affects GATA3
| 4
USP25 deubiquitinates GATA3. 4 / 4
| 4
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"Furthermore, USP21 also deubiquitinates GATA3, a transcription factor which limit T reg induced pro inflammatory responses, and its expression was noted to be upregulated in asthmatic patients."
31481479
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"Recent reports demonstrate that GATA3 can be deubiquitinated by Usp21 which rescues it from proteosomal degradation and stabilises GATA3 protein levels [XREF_BIBR]."
25962961
reach
"For example, USP21 can mediate deubiquitination of GATA3 and maintain GATA3 expression in regulatory T cells."
28105162
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"Another DUB, USP21, which is itself activation induced, interacts with and deubiquitinates GATA3 to stabilize its expression in cell lines and primary human Tregs."
24777637
USP25 affects FOXM1
| 4
USP25 deubiquitinates FOXM1. 4 / 4
| 4
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"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 (USP21), which deubiquitinates FOXM1."
34335925
reach
"FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal like Breast Cancer."
30865895
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"Similarly, USP21 WT, but not USP21 C221A, immunopurified from 293T cells reduced polyubiquitination of FOXM1 isolated from proteasome inhibitor treated 293T cells in an in vitro deubiquitination assay (XREF_SUPPLEMENTARY)."
30865895
reach
"USP21 increases the stability of FOXM1, and USP21 binds and deubiquitinates FOXM1 in vivo and in vitro, indicating a direct enzyme-substrate relationship."
30865895
USP25 affects ubH2A
| 3
USP25 leads to the deubiquitination of ubH2A. 3 / 3
| 3
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"Besides, USP21 could promote transcription by deubiquitylating ubH2A in vitro [XREF_BIBR]."
33546726
reach
"The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro."
24278184
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"Furthermore, both recombinant USP21 variants activate transcription by deubiquitylating ubH2A in vitro."
24278184
USP25 affects STING1
| 3
Modified USP25 leads to the deubiquitination of STING1. 2 / 2
| 2
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"Our data showed that overexpression of USP21-WT, but not USP21-CA, greatly attenuated STING ubiquitination (XREF_FIG)."
28254948
reach
"Moreover, overexpression of USP21 also inhibited the HSV-1-induced STING ubiquitination (XREF_FIG)."
28254948
USP25 deubiquitinates STING1. 1 / 1
| 1
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"USP21 deubiquitinates K27/63 linked polyubiquitination of STING."
28254948
USP25 affects IFIH1
| 3
USP25 deubiquitinates IFIH1. 3 / 3
| 3
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"USP21 also deubiquitinated MDA5 to inhibit antiviral response [XREF_BIBR]."
31208841
reach
"USP21 also deubiquitinated MDA5 to inhibit antiviral response [24]."
31208841
reach
"Furthermore, we also found that USP21 binds to two other RLR family members (MDA5 and LGP2) and deubiquitinates MDA5, suggesting USP21 acts as a major negative regulator to restrict RLR mediated antiviral responses through deubiquitinating RIG-I and MDA5."
24493797
USP25 affects FOXP3
| 3
USP25 deubiquitinates FOXP3. 2 / 2
| 2
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"USP21 deubiquitinates FOXP3 in Treg cells."
27857073
reach
"In previous studies, we showed that Foxp3 could be ubiquitinated and degraded by the E3 ubiquitin ligase Stub1 (STIP1 homology and U-Box containing protein 1) or deubiquitinated and stabilized by the deubiquitinase USP21 (ubiquitin specific peptidase 21) (Chen et al., 2013; Yang et al., 2015; Li et al., 2016)."
29352742
USP25 deubiquitinates FOXP3 on lysine. 1 / 1
| 1
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"His ubiquitin pulldown assays further confirmed that USP21 could deubiquitinate FOXP3 at these seven lysine residues and that the 7R construct was unresponsive to USP21 mediated deubiquitination (XREF_SUPPLEMENTARY)."
27857073
USP25 affects TNKS
1 | 1
USP25 leads to the deubiquitination of TNKS. 2 / 2
1 | 1
ubibrowser
"USP25 regulates Wnt signaling by controlling the stability of tankyrases"
28619731
reach
"TNKS1 ubiquitination level was knowingly increased in USP25-knockdown glioma cells and reduced in USP25-overexpressed glioma cells, suggesting TNKS1 ubiquitination levels were negatively regulated by USP25."
35450028
USP25 affects TNF
| 2
USP25 deubiquitinates TNF. 2 / 2
| 2
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"Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling."
24260525
reach
"For example, USP21 deubiquitinates receptor interacting protein kinase 1 (RIP1) and repress the signaling transduction activity downstream of TNFalpha receptor 1 (TNFR1) and NFkappaB pathway [XREF_BIBR]."
27259257
USP25 affects SLC2A4
| 2
USP25 deubiquitinates SLC2A4. 2 / 2
| 2
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"USP25, recruited through interaction with TNKS, could then deubiquitinate GLUT4, trapping it in GSVs and preventing its trafficking to the lysosome."
30886164
reach
"USP25, thus positioned, could then serve to deubiquitinate GLUT4, rescuing the transporter from lysosomal degradation."
30886164
USP25 affects PTEN
| 2
USP25 deubiquitinates PTEN. 2 / 2
| 2
reach
"Conclusions: In this study, we investigated that USP25 can regulate the PI3K/AKT signaling pathway by deubiquitinating PTEN, thus affecting the proliferation and apoptosis of GCs and contributing to the pathogenesis of PCOS."
34805185
reach
"Finally, we verified that USP25 could deubiquitinate PTEN in KGN cells."
34805185
USP25 affects PPIP5K1
| 2
Modified USP25 leads to the deubiquitination of PPIP5K1. 2 / 2
| 2
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"However, overexpression of USP25 did not block ubiquitination of IPS-1 (XREF_FIG)."
24260525
reach
"However, overexpression of USP25 did not block ubiquitination of IPS-1 (Figure 7C)."
24260525
USP25 affects FOXD1
| 2
USP25 deubiquitinates FOXD1. 2 / 2
| 2
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"USP21 promotes self-renewal and tumorigenicity of mesenchymal glioblastoma stem cells by deubiquitinating and stabilizing FOXD1."
35974001
reach
"Silencing of USP21 enhances polyubiquitination of FOXD1, promotes its proteasomal degradation, and ultimately attenuates MES identity in GSCs, while these effects could be largely restored by reintroduction of FOXD1."
35974001
USP25 affects AURKA
| 2
USP25 deubiquitinates AURKA. 2 / 2
| 2
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"USP21 contributes to the aggressiveness of laryngeal cancer cells by deubiquitinating and stabilizing AURKA."
36919585
reach
"We aimed to explore whether USP21 affected laryngeal cancer progress through deubiquitinating AURKA."
36919585
USP25 affects sensor
| 1
USP25 leads to the deubiquitination of sensor. 1 / 1
| 1
reach
"USP21 was also reported to antagonize the ubiquitination of anti-viral sensor RIG-I, implicating USP21 as a negative regulator of type-I interferon production and anti-viral immunity (Fan et al., 2014[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
USP25 affects retinoic acid
| 1
USP25 deubiquitinates retinoic acid. 1 / 1
| 1
reach
"Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling."
24260525
USP25 affects receptor-interacting protein kinase 1
| 1
USP25 deubiquitinates receptor-interacting protein kinase 1. 1 / 1
| 1
reach
"For example, USP21 deubiquitinates receptor interacting protein kinase 1 (RIP1) and repress the signaling transduction activity downstream of TNFalpha receptor 1 (TNFR1) and NFkappaB pathway [XREF_BIBR]."
27259257
USP25 affects isotretinoin
| 1
USP25 deubiquitinates isotretinoin. 1 / 1
| 1
reach
"Mechanistically, USP25 deubiquitinated retinoic acid inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor mediated IFN signaling."
24260525
USP25 affects TNFalpha receptor
| 1
USP25 deubiquitinates TNFalpha receptor. 1 / 1
| 1
reach
"For example, USP21 deubiquitinates receptor interacting protein kinase 1 (RIP1) and repress the signaling transduction activity downstream of TNFalpha receptor 1 (TNFR1) and NFkappaB pathway [XREF_BIBR]."
27259257
USP25 affects TCF7
| 1
USP25 deubiquitinates TCF7. 1 / 1
| 1
reach
"Mechanistically, USP21 deubiquitinates and stabilizes the TCF/LEF transcription factor TCF7, which promotes cancer cell stemness."
31488580
USP25 affects TCF/LEF
| 1
USP25 deubiquitinates TCF/LEF. 1 / 1
| 1
reach
"Mechanistically, USP21 deubiquitinates and stabilizes the TCF/LEF transcription factor TCF7, which promotes cancer cell stemness."
31488580
USP25 affects SYVN1
| 1
USP25 leads to the deubiquitination of SYVN1. 1 / 1
| 1
reach
"Instead, we observed that USP25 rescued ERAD substrates and reduced levels of ubiquitination of HRD1 associated species."
22590560
USP25 affects RRub
| 1
USP25 deubiquitinates RRub on S40. 1 / 1
| 1
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"OTUD3 and USP21 deubiquitylate 40S ribosomal proteins following RRub induction."
32011234
USP25 affects RNF135
| 1
USP25 deubiquitinates RNF135. 1 / 1
| 1
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"Moreover, USP21 deubiquitinated RNF135 mediated RIG-I polyubiquitination both in vivo and in vitro (XREF_FIG)."
24493797
USP25 affects RIG-I-CARD
| 1
USP25 deubiquitinates RIG-I-CARD on A20. 1 / 1
| 1
reach
"Interestingly, in our in vitro assay, USP21 deubiquitinates RIG-I-CARD, whereas A20 fails to do so, even though both USP21 and A20 inhibit RIG-I-CARD overexpression induced RIG-I-CARD polyubiquitination in vivo (XREF_FIG)."
24493797
USP25 affects PRKDC
| 1
USP25 deubiquitinates PRKDC. 1 / 1
| 1
reach
"Mechanistically, USP21 deubiquitinated DNA-PKcs and ACLY, which led to AMPK inhibition."
34523817
USP25 affects NFkappaB
| 1
USP25 deubiquitinates NFkappaB. 1 / 1
| 1
reach
"For example, USP21 deubiquitinates receptor interacting protein kinase 1 (RIP1) and repress the signaling transduction activity downstream of TNFalpha receptor 1 (TNFR1) and NFkappaB pathway [XREF_BIBR]."
27259257
USP25 affects MARVELD2
1 |
USP25 deubiquitinates MARVELD2. 1 / 1
1 |
ubibrowser
"USP25 catalyzed deubiquitination of the TRiC protein and stabilized the chaperonin, thereby reducing accumulation of misfolded polyglutamine protein aggregates. 0.75"
25755282
USP25 affects MARK1
| 1
USP25 deubiquitinates MARK1. 1 / 1
| 1
reach
"USP21 deubiquitylates MARK proteins to control their stability."
28969054
USP25 affects K48-
| 1
USP25 leads to the deubiquitination of K48- on K63. 1 / 1
| 1
reach
"USP21 is also identified to promote deubiquitination of both K48- and K63 linked polyubiquitinated RIP1 but whether USP21 functions in coordination with the above mentioned E3s needs to be elucidated."
29479529
USP25 affects Interferon
| 1
Modified USP25 leads to the deubiquitination of Interferon. 1 / 1
| 1
reach
"Overexpression of USP21 inhibited RNA virus induced RIG-I polyubiquitination and RIG-I-mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN-alpha and beta production, and antiviral responses in MEFs in response to RNA virus infection."
24493797
USP25 affects IL33
| 1
USP25 deubiquitinates IL33. 1 / 1
| 1
reach
"Deubiquitination and stabilization of IL-33 by USP21."
25197364
USP25 affects Histone
| 1
USP25 deubiquitinates Histone. 1 / 1
| 1
reach
"If that is the case, the global regulation of histone deubiquitination by USP21 requires further investigation."
28105162
USP25 affects HIF1
| 1
USP25 deubiquitinates HIF1. 1 / 1
| 1
reach
"Mechanistically, USP25 deubiquitinates and stabilizes the HIF-1α transcription factor."
35440539
USP25 affects GS26575
| 1
USP25 leads to the deubiquitination of GS26575. 1 / 1
| 1
reach
"18, 19 USP21 can modulate cell cycle progression by deubiquitinating Forkhead box M1 (FOXM1) in basal like breast cancer."
33389794
USP25 affects Forkhead
| 1
USP25 leads to the deubiquitination of Forkhead. 1 / 1
| 1
reach
"18, 19 USP21 can modulate cell cycle progression by deubiquitinating Forkhead box M1 (FOXM1) in basal like breast cancer."
33389794
USP25 affects Figure 7B
| 1
Modified USP25 leads to the deubiquitination of Figure 7B. 1 / 1
| 1
reach
"We observed that overexpression of USP25 significantly inhibited ubiquitination of RIG-I (Figure 7B), TRAF2 (Figure 7D), and TRAF6 (Figure 7E)."
24260525
USP25 affects FOSL1
| 1
USP25 leads to the deubiquitination of FOSL1. 1 / 1
| 1
reach
"These results demonstrate that USP21 enhances Fra-1 stability and AP-1 target gene expression by deubiquitinating Fra-1."
31947604
USP25 affects FLAG-RIG-I-CARD
| 1
Modified USP25 leads to the deubiquitination of FLAG-RIG-I-CARD. 1 / 1
| 1
reach
"Overexpression of USP21 WT but not C221A mutant abrogated FLAG-RIG-I-CARD polyubiquitination (XREF_FIG)."
24493797
USP25 affects FLAG
| 1
Modified USP25 leads to the deubiquitination of FLAG. 1 / 1
| 1
reach
"We further examined the role of USP21 in the inhibition of SeV induced RIG-I polyubiquitination and found that overexpression of USP21 WT but not C221A mutant inhibited SeV induced polyubiquitination of both FLAG tagged and endogenous RIG-I (XREF_FIG)."
24493797
USP25 affects ERAD substrate CD3delta [
| 1
USP25 leads to the deubiquitination of ERAD substrate CD3delta [. 1 / 1
| 1
reach
"Finally, USP25, which interacts with p97 as well as HRD1, decreases ubiquitination of the ERAD substrate CD3delta [XREF_BIBR]."
28159894
USP25 affects CUL
| 1
USP25 deubiquitinates CUL. 1 / 1
| 1
reach
"Alternatively, USP21 could be acting directly to deubiquitylate the substrates of the cullin RING ligase, in an analogous fashion to USP28, which associates with the cullin-1-adapter FBW7 to deubiquitylate a range of substrates, including MYC."
27621083
USP25 affects CD3D
1 |
USP25 deubiquitinates CD3D. 1 / 1
1 |
ubibrowser
"Thus, the ability of USP25 to both bind and cleave ubiquitin appears to be required to exert the rescue effect on CD3未."
22590560
USP25 affects CD274
| 1
USP25 deubiquitinates CD274. 1 / 1
| 1
reach
"Deubiquitination and Stabilization of PD-L1 by USP21."
34956491
USP25 affects CCT4
1 |
USP25 deubiquitinates CCT4. 1 / 1
1 |
ubibrowser
"USP25 catalyzed deubiquitination of the TRiC protein and stabilized the chaperonin, thereby reducing accumulation of misfolded polyglutamine protein aggregates."
25755282
USP25 affects BAZ2A
| 1
USP25 deubiquitinates BAZ2A. 1 / 1
| 1
reach
"TIP5 is deubiquitylated and stabilized by USP21, resulting in an increase of H3K4me3 and rDNA promoter methylation."
27516771
USP25 affects APP
1 |
USP25 deubiquitinates APP. 1 / 1
1 |
ubibrowser
"Similarly to what occurs with?CD3delta, overexpression of?USP25?increases APP half-life. Again, this effect depends on the catalytic activity of?USP25, as catalytically inactive?USP25(C178S) does not alter APP turnover."
22590560
USP25 affects ACLY
| 1
USP25 deubiquitinates ACLY. 1 / 1
| 1
reach
"Mechanistically, USP21 deubiquitinated DNA-PKcs and ACLY, which led to AMPK inhibition."
34523817