IndraLab

Statements

USP25 deubiquitinates NANOG. 15 / 15
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"Since USP21 is a DUB, we examined whether USP21 could directly interact with and deubiquitinate Nanog."
27886188
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"USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency."
29263902
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"USP21 directly interacts with and deubiquitinates Nanog."
27886188
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"USP21 deubiquitylates the K48-type linkage of the ubiquitin chain of Nanog, stabilizing Nanog."
29263902
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"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
30891497
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"Considering that USP21 deubiquitylates Nanog, we sought to examine the functional roles of USP21 in mESCs."
29263902
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"Next, we examined whether USP21 could deubiquitinate Nanog."
27886188
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"Collectively, these data suggest that USP21 can deubiquitylate and stabilize Nanog."
29263902
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"USP21 deubiquitylates Nanog."
29263902
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"Recently, three groups independently identified ubiquitin specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein."
29263917
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"Here we report that the deubiquitinase USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse ESCs (mESCs)."
27886188
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"Erratum : USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency."
29266131
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"USP21 interacts with Nanog protein in embryonic stem cells in vivo and in vitro to deubiquitylate the K48-type linkage of the ubiquitin chain of Nanog, thereby stabilizing Nanog and in turn maintaining the stemness of embryonic stem cells in mice."
33791299
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"Indeed, we showed that USP21 reduced Nanog ubiquitylation directly in an in vitro deubiquitylation assay (XREF_FIG)."
29263902
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"We found that WT-USP21, but not CA-USP21, efficiently deubiquitinated Nanog (XREF_FIG), indicating that USP21 was a direct DUB for Nanog."
27886188