IndraLab

Statements

USP25 deubiquitinates NANOG. 20 / 20
| 20
reach
"For example, Oct4 and Sox2 protein levels are regulated by the E3 ligase WWP2, and ubiquitin-specific-processing protease 21 (Usp21) deubiquitinates and stabilizes Nanog, which maintains pluripotency, while FBXW8, an E3 ligase, ubiquitinates and destabilizes Nanog, thereby promoting ESC differentiation."
30891497
reach
"USP21, as a deubiquitinase, deubiquitylates the K48-type linkage of the ubiquitin chain of Nanog, stabilizing Nanog."
39367978
reach
"Here we report that the deubiquitinase USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse ESCs (mESCs)."
27886188
reach
"Recently, three groups independently identified ubiquitin specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein."
29263917
reach
"USP21 directly interacts with and deubiquitinates Nanog."
27886188
reach
"USP21 affects stem cell pluripotency through deubiquitylating Nanog[25]."
38577450
reach
"Since USP21 is a DUB, we examined whether USP21 could directly interact with and deubiquitinate Nanog."
27886188
reach
"Next, we examined whether USP21 could deubiquitinate Nanog."
27886188
reach
"USP21 interacts with Nanog protein in embryonic stem cells in vivo and in vitro to deubiquitylate the K48-type linkage of the ubiquitin chain of Nanog, thereby stabilizing Nanog and in turn maintaining the stemness of embryonic stem cells in mice."
33791299
reach
"We found that WT-USP21, but not CA-USP21, efficiently deubiquitinated Nanog (XREF_FIG), indicating that USP21 was a direct DUB for Nanog."
27886188
reach
"Ubiquitin-specific peptidase 21 (USP21) deubiquitylates NANOG but not OCT4 or SOX2."
37047234
reach
"USP21 deubiquitylated the ubiquitin chain of Nanog in a K48-linkage dependent manner [152] ."
36371028
reach
"USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency."
29263902
reach
"Erratum : USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency."
29266131
reach
"USP21 deubiquitylates the K48-type linkage of the ubiquitin chain of Nanog, stabilizing Nanog."
29263902
reach
"USP21 deubiquitylates Nanog."
29263902
reach
"Indeed, we showed that USP21 reduced Nanog ubiquitylation directly in an in vitro deubiquitylation assay (XREF_FIG)."
29263902
reach
"Collectively, these data suggest that USP21 can deubiquitylate and stabilize Nanog."
29263902
reach
"Considering that USP21 deubiquitylates Nanog, we sought to examine the functional roles of USP21 in mESCs."
29263902
reach
"These results indicate that USP21 deubiquitinates K48-specific polyubiquitin chains of NANOG, suggesting that the proteasomal degradation of NANOG is regulated by USP21.It has been demonstrated that t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27956178