IndraLab

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USP25 deubiquitinates TRAF6. 13 / 13
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"Act1 mediated K63 linked ubiquitination of TRAF6 was inhibited by overexpression of USP25, but not USP25 (C178S) in 293T cells or in an in vitro deubiquitination system (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Therefore, USP25 may indirectly lead to deubiquitination of TRAF5 or TRAF6 through its tightly associated proteins."
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"However, Zhong et al. 's study using HEK293T cells supported deubiquitination of TRAF6 by USP25 [XREF_BIBR]."
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"Similarly, Usp25 deubiquitinates both TRAF5 and TRAF6 and thereby restricts downstream gene expression."
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"Mechanistically, USP25 deubiquitinated retinoic acid inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor mediated IFN signaling."
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"Mechanistically, stimulation with IL-17 induced the association of USP25 with the adaptors TRAF5 and TRAF6, and USP25 induced removal of Lys63-linked ubiquitination in TRAF5 and TRAF6 mediated by the adaptor Act2."
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"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
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"Taken together, our results demonstrate that USP25 negatively regulates IL-17-triggered ubiquitination of TRAF6 and TRAF5."
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"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [XREF_BIBR]."
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"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [23]."
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"USP25 deubiquitinates RIG-I, TRAF2 and TRAF6."
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"However, some studies have given different results regarding USP25’s ability to deubiquitinate TRAF6."
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"However, Zhong et al.’s study using HEK293 T cells supported deubiquitination of TRAF6 by USP25 [20]."
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