IndraLab

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USP25 deubiquitinates TRAF6. 12 / 12
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"Similarly, Usp25 deubiquitinates both TRAF5 and TRAF6 and thereby restricts downstream gene expression."
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"Taken together, our results demonstrate that USP25 negatively regulates IL-17-triggered ubiquitination of TRAF6 and TRAF5."
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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"In virus infection, USP25 enhances the activation of IRF3 and NF-κB signaling by deubiquitinating and stabilizing TRAF3 and TRAF6, thereby promoting innate antiviral responses [24] ."
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"Mechanistically, USP25 deubiquitinated retinoic acid inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor mediated IFN signaling."
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"USP25 deubiquitinates RIG-I, TRAF2 and TRAF6."
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"Similarly, ubiquitin-specific peptidase 25 (USP25) can deubiquitinate TRAF6, thereby blocking the IL-17 signaling pathway."
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"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [XREF_BIBR]."
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"Mechanistically, stimulation with IL-17 induced the association of <span class="match term0">USP25</span> with the adaptors TRAF5 and <span class="match term1">TRAF6</span>, and <span class="match term0">USP25</span> induced removal of Lys63-linked ubiquitination in TRAF5 and <span class="match term1">TRAF6</span> mediated by the adaptor Act2."
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"However, Zhong et al. 's study using HEK293T cells supported deubiquitination of TRAF6 by USP25 [XREF_BIBR]."
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"Therefore, USP25 may indirectly lead to deubiquitination of TRAF5 or TRAF6 through its tightly associated proteins."
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"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
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