IndraLab

Statements

USP25 deubiquitinates DDX58. 11 / 11
| 11
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"USP21 deubiquitinated RIG-I in HEK293 T cells [24]."
31208841
reach
"Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling."
24260525
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"USP21 binds to and deubiquitinates RIG-I."
24493797
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"USP17 and USP25 also deubiquitinate RIG-I in a different manner; that is, USP17 stabilizes RIG-I by K48-deubiquitination, while USP25 inhibits RIG-I degradation by K63-deubiquitination [37, 38] ."
33922750
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"RNA virus induced RIG-1 can be deubiquitinated by USP21 14."
29706623
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"Therefore, it is highly likely that USP21 acts as a RIG-I polyubiquitination guard to prevent extensive RIG-I polyubiquitination."
24493797
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"In antiviral responses, USP21 binds to and deubiquitinates RIG-I in the cytoplasm to exert an immunomodulatory effect; USP21 can also hydrolyzes the K27/63 linked polyubiquitin chain on STING to negatively regulate DNA virus induced type I interferon production [XREF_BIBR]."
33628844
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"We reasoned that USP21 might deubiquitinate RIG-I to inhibit virus induced IRF3 activation."
24493797
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"USP21 was also reported to antagonize the ubiquitination of anti-viral sensor RIG-I, implicating USP21 as a negative regulator of type-I interferon production and anti-viral immunity (Fan et al., 2014[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
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"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
24260525
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"USP25 deubiquitinates RIG-I, TRAF2 and TRAF6."
24260525