IndraLab

Statements

USP25 deubiquitinates RIGI. 10 / 10
| 10
reach
"USP25 deubiquitinates RIG-I, TRAF2 and TRAF6."
24260525
reach
"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
24260525
reach
"We reasoned that USP21 might deubiquitinate RIG-I to inhibit virus induced IRF3 activation."
24493797
reach
"USP21 binds to and deubiquitinates RIG-I."
24493797
reach
"USP17 and USP25 also deubiquitinate RIG-I in a different manner; that is, USP17 stabilizes RIG-I by K48-deubiquitination, while USP25 inhibits RIG-I degradation by K63-deubiquitination [37, 38] ."
33922750
reach
"USP21 was also reported to antagonize the ubiquitination of anti-viral sensor RIG-I, implicating USP21 as a negative regulator of type-I interferon production and anti-viral immunity (Fan et al., 2014[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24647359
reach
"Therefore, it is highly likely that USP21 acts as a RIG-I polyubiquitination guard to prevent extensive RIG-I polyubiquitination."
24493797
reach
"RNA virus induced RIG-1 can be deubiquitinated by USP21 14."
29706623
reach
"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
reach
"In antiviral responses, USP21 binds to and deubiquitinates RIG-I in the cytoplasm to exert an immunomodulatory effect; USP21 can also hydrolyzes the K27/63 linked polyubiquitin chain on STING to negatively regulate DNA virus induced type I interferon production [XREF_BIBR]."
33628844