IndraLab

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USP25 deubiquitinates GATA3. 6 / 6
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"USP21 interacts with and deubiquitinates GATA3, thereby stabilizing the expression level of GATA3."
31078284
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"Furthermore, USP21 also deubiquitinates GATA3, a transcription factor which limit T reg induced pro inflammatory responses, and its expression was noted to be upregulated in asthmatic patients."
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"Zhang et al. [10] found that USP21 promotes the deubiquitination of GATA3 in Treg cells, increases its posttranslational stability and expression, and subsequently upregulates FOXP3 expression to enha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, USP21 can mediate deubiquitination of GATA3 and maintain GATA3 expression in regulatory T cells."
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"Recent reports demonstrate that GATA3 can be deubiquitinated by Usp21 which rescues it from proteosomal degradation and stabilises GATA3 protein levels [XREF_BIBR]."
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"Another DUB, USP21, which is itself activation induced, interacts with and deubiquitinates GATA3 to stabilize its expression in cell lines and primary human Tregs."
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