IndraLab

Statements

USP25 deubiquitinates STING1. 5 / 5
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"USP21 deubiquitinates K27/63 linked polyubiquitination of STING."
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"USP21 deubiquitinates STING, enhancing its stability and activity, which then promotes the downstream activation of IRF3 and IRF7, thereby amplifying the antiviral immune response (59)."
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"Moreover, overexpression of Ubv.21.4CΔ2, the truncated Ubv.21.4 form lacking the last two glycines, also efficiently inhibited cellular USP21 activity, blocking the deubiquitylation of RIP1 and STING by USP21 (Ernst et al., 2013; Chen et al., 2017a)."
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"The USP family of DUBs is very important, with USP13, USP18, USP20, USP21, USP44, and USP49 shown to mediate the deubiquitination of STING (Chen et al., 2021)."
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"To this end, we developed a USP21 activity assay that is based on the deubiquitination of a STING-derived peptide (a USP21-specific substrate ) by purified recombinant human full-length USP21 using time-resolved fluorescence resonance energy transfer (TR-FRET) technology (referred to as a homogeneous time-resolved fluorescence (HTRF)-assay, for details see the Supporting Information)."
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