IndraLab

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USP25 deubiquitinates FOXM1. 10 / 10
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"Subsequently, Arceci et al. revealed that USP21 amplification was related to proliferation and paclitaxel resistance in basal-like breast cancer (BLBC) by deubiquitylating and stabilizing the cell cycle transcription factor FoxM1 (Arceci et al., 2019)."
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"Likewise, FoxM1 deubiquitylation by USP21 contributes to both cell growth and radioresistance in cervical cancer (Li et al., 2022)."
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"FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal like Breast Cancer."
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"USP21 increases the stability of FOXM1, and USP21 binds and deubiquitinates FOXM1 in vivo and in vitro, indicating a direct enzyme-substrate relationship."
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"Similarly, USP21 WT, but not USP21 C221A, immunopurified from 293T cells reduced polyubiquitination of FOXM1 isolated from proteasome inhibitor treated 293T cells in an in vitro deubiquitination assay (XREF_SUPPLEMENTARY)."
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"In addition, USP21 deubiquitinates FOXM1 to strengthen radioresistance in cervical cancer through the Hippo signaling pathway[17]."
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"Another study about basal-like breast cancer reported that USP21 promoted the progression of the cell cycle and resistance to paclitaxel by regulating FOXM1 deubiquitination [15]."
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"HDACi treatment increased the ubiquitination level of FOXM1 by suppressing ubiquitin-specific peptidase 21 (USP21), which deubiquitinates FOXM1."
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"USP21 binds and deubiquitinates FOXM1 in vivo and in vitro, thus increasing FOXM1 stability."
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"FOXM1 deubiquitinated by USP21 modulates cell cycle and paclitaxel sensitivity of basal-like breast cancer cells [38]."
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