IndraLab

Statements

USP25 deubiquitinates TCF7. 6 / 6
| 6
reach
"USP21 is best known for its nuclear function as a histone deubiquitinase, although nuclear USP21 promotes pancreatic tumor growth by deubiquitinating the transcription factor TCF7, amplifying canonical Wnt signaling, and enhancing tumor stem cell properties (Hou et al. 2019)."
34599002
reach
"USP21 deubiquitinates and stabilizes TCF/LEF transcription factor TCF7, thereby promoting pancreatic cancer cell dryness [5]."
36820242
reach
"USP21 deubiquitinates the transcription factor 7 (TCF7) and amplifies canonical Wnt signaling [52]."
37298264
reach
"Mechanistically, USP21 promotes cancer cell proliferation by deubiquitinating and stabilising the TCF/LEF transcription factor TCF7 (85)."
36969062
reach
"USP21 promotes pancreatic cancer cell stemness by deubiquitinating and stabilizing the TCF/LEF transcription factor TCF7 [32]."
37752518
reach
"To determine the specific sites of TCF7 protein that are deubiquitinated by USP21, we ranked the predicted ubiquitinated lysine residues of TCF7 conserved in human and mouse by three bioinformatic tools (UbiSite, BDM-PUB, and UbPred), the top four of which (K52, K99, K277, and K406) with high confidence scores were mutated from lysine to arginine (K to R) individually to block the site-specific ubiquitination."
31488580