IndraLab

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USP25 deubiquitinates BRCA2. 5 / 5
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"We now show that USP21 interacts with and deubiquitinates BRCA2 and that USP21 loss results in decreased BRCA2 expression in tumor cell lines."
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"USP21 interacts with and deubiquitinates BRCA2."
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"USP4, for example, interacts directly with end resection factors CtIP and MRN [172], USP21 deubiquitinates and stabilizes BRCA2 to promote RAD51 binding and successful HR [173], and USP10 deubiquitinates and stabilizes p53 to promote its nuclear localization and apoptosis in response to DSBs [174]."
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"To determine whether USP21 is sufficient to deubiquitinate BRCA2 fragments, we performed in vitro deubiquitination assays using HA ubiquitinated, immuno purified BRCA2 fragments as well as full-length Flag-BRCA2."
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"To determine whether USP21 can promote the deubiquitination of endogenous BRCA2 and/or the BRCA2 associated RAD51 and PALB2 proteins XREF_BIBR, XREF_BIBR, we measured the extent of (poly-) ubiquitin modifications on either protein in the presence or absence of USP21 overexpression."
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