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"In previous studies, we showed that Foxp3 could be ubiquitinated and degraded by the E3 ubiquitin ligase Stub1 (STIP1 homology and U-Box containing protein 1) or deubiquitinated and stabilized by the deubiquitinase USP21 (ubiquitin specific peptidase 21) (Chen et al., 2013; Yang et al., 2015; Li et al., 2016)."