IndraLab

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USP25 deubiquitinates TRAF5. 6 / 6
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"Similarly, Usp25 deubiquitinates both TRAF5 and TRAF6 and thereby restricts downstream gene expression."
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"Taken together, our results demonstrate that USP25 negatively regulates IL-17-triggered ubiquitination of TRAF6 and TRAF5."
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"Mechanistically, stimulation with IL-17 induced the association of <span class="match term0">USP25</span> with the adaptors <span class="match term1">TRAF5</span> and TRAF6, and <span class="match term0">USP25</span> induced removal of Lys63-linked ubiquitination in <span class="match term1">TRAF5</span> and TRAF6 mediated by the adaptor Act1."
23042150
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"USP25 also deubiquitinated TRAF5 and TRAF6 to regulate in IL-17 signaling [XREF_BIBR]."
31208841
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"We found that Act1 mediated K63 linked ubiquitination of TRAF5 (XREF_SUPPLEMENTARY), which was substantially attenuated by USP25 but not USP25 (C178S) in 293T cells or in an in vitro deubiquitination system (XREF_FIG and XREF_SUPPLEMENTARY)."
23042150
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"Therefore, USP25 may indirectly lead to deubiquitination of TRAF5 or TRAF6 through its tightly associated proteins."
23042150