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USP25 deubiquitinates TRAF3. 7 / 8
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
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"We mentioned in a previous section that USP25 deubiquitinates TRAF3 and interacts with TRAF6, increasing expression of Tnf in HEK293T cells [XREF_BIBR, XREF_BIBR], while in MEF cells, USP25 negatively affects TNF-alpha-induced NF-kappaB activation [XREF_BIBR]."
31208841
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"USP25 inhibits ubiquitination and degradation of TRAF3, thereby impeding the activation of c-Jun N-terminal kinase and P38."
37245535
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"USP25 is a deubiquitinating enzyme that initiates antiviral immunity by deubiquitinating TRAF3 and triggering the antiviral signaling pathway."
39946759
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"Because the activation of TLR4 results in the K 48 -linked ubiquitination and degradation of TRAF3, we next determined the effects of a deficiency in USP25 on the LPS induced ubiquitination and degradation of TRAF3."
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"In the present study, we found that USP25 inhibited the ubiquitination and degradation of TRAF3, thereby inhibiting the activation of JNK and P38."
30579117
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"In virus infection, USP25 enhances the activation of IRF3 and NF-κB signaling by deubiquitinating and stabilizing TRAF3 and TRAF6, thereby promoting innate antiviral responses [24] ."
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