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USP25 deubiquitinates TRAF3. 5 / 5
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"Taking it one step further, Lin et al. uncovered that USP25 stabilizes TRAF3 in a DUB activity dependent manner by deubiquitinating K48-Ub of TRAF3 in bone marrow-derived macrophages (BMDM) cells, inhibiting TLR4 signaling-induced innate immune responses [21]."
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"We mentioned in a previous section that USP25 deubiquitinates TRAF3 and interacts with TRAF6, increasing expression of Tnf in HEK293 T cells [21,22], while in MEF cells, USP25 negatively affects TNF-α-induced NF-κB activation [20]."
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"Because the activation of TLR4 results in the K 48 -linked ubiquitination and degradation of TRAF3, we next determined the effects of a deficiency in USP25 on the LPS induced ubiquitination and degradation of TRAF3."
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"We mentioned in a previous section that USP25 deubiquitinates TRAF3 and interacts with TRAF6, increasing expression of Tnf in HEK293T cells [XREF_BIBR, XREF_BIBR], while in MEF cells, USP25 negatively affects TNF-alpha-induced NF-kappaB activation [XREF_BIBR]."
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"Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3"
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