IndraLab

Statements

USP25 deubiquitinates MAP2K2. 7 / 7
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"USP21 deubiquitinates and stabilizes MEK2, which contributes to tumorigenesis ."
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"USP21 deubiquitylates MEK2."
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"For instance, USP21 induced the activation of the ERK signaling pathway by deubiquitinating MEK2 and stabilizing it, which promoted the growth of hepatocellular cancer [19]."
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"USP21 deubiquitinated and stabilized MEK2, thus activating the ERK pathway for cell proliferation, colony formation, and cell cycle progression, and promoted tumor growth [54]."
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"Since USP21 functions as a deubiquitylase, we next ask whether USP21 deubiquitylates MEK2."
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"XREF_FIG, wild type USP21 decreased MEK2 ubiquitination, whereas the C221A USP21 deubiquitinase deficient mutant failed to do so."
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"Conversely, USP21 inhibition increased MEK2 ubiquitylation in cells."
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