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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP25 deubiquitinates IFIH1. 3 / 3

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"USP21 also deubiquitinated MDA5 to inhibit antiviral response [XREF_BIBR]."

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"USP21 also deubiquitinated MDA5 to inhibit antiviral response [24]."

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"Furthermore, we also found that USP21 binds to two other RLR family members (MDA5 and LGP2) and deubiquitinates MDA5, suggesting USP21 acts as a major negative regulator to restrict RLR mediated antiviral responses through deubiquitinating RIG-I and MDA5."

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USP25 deubiquitinates IFIH1. 3 / 3

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