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USP25 deubiquitinates IFIH1. 3 / 3
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"USP21 also deubiquitinated MDA5 to inhibit antiviral response [XREF_BIBR]."

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"USP21 also deubiquitinated MDA5 to inhibit antiviral response [24]."

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"Furthermore, we also found that USP21 binds to two other RLR family members (MDA5 and LGP2) and deubiquitinates MDA5, suggesting USP21 acts as a major negative regulator to restrict RLR mediated antiviral responses through deubiquitinating RIG-I and MDA5."