IndraLab

Statements

USP25 deubiquitinates TRAF2. 4 / 4
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"Mechanistically, USP25 deubiquitinated retinoic acid inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor mediated IFN signaling."
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"In addition, wild-type USP25 significantly inhibits ubiquitination of RIG-I, TRAF2, and TRAF6, which is essential for activation of type I IFN signaling."
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"USP25 deubiquitinates RIG-I, TRAF2 and TRAF6."
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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