IndraLab

Statements

USP25 deubiquitinates CD274. 3 / 3
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"Notably, a recent study found that USP21 could also deubiquitylate and stabilize PD-L1, suggesting a potential role of USP21 in immunosuppression (Yang et al., 2021)."
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"Simultaneously, gallic acid can enhance the anti-tumor effect of anti–PD-1 immune checkpoint blocking and downregulate the expression of PD-L1 protein in Tregs, indicating that the deubiquitinating enzyme Usp21 can deubiquitinate and stabilize the PD-L1 protein."
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"Deubiquitination and Stabilization of PD-L1 by USP21."
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